-
1
-
-
0033977101
-
Families of transmembrane sugar transport proteins
-
Saier M.H. Families of transmembrane sugar transport proteins. Mol. Microbiol. 2000, 35:699-710.
-
(2000)
Mol. Microbiol.
, vol.35
, pp. 699-710
-
-
Saier, M.H.1
-
2
-
-
0027507306
-
A major superfamily of transmembrane facilitators that catalyze unipolar symport and antiport
-
Marger M.D., Saier M.H. A major superfamily of transmembrane facilitators that catalyze unipolar symport and antiport. Trends Biochem. Sci. 1993, 18:13-20.
-
(1993)
Trends Biochem. Sci.
, vol.18
, pp. 13-20
-
-
Marger, M.D.1
Saier, M.H.2
-
6
-
-
0020536028
-
Mechanism of lactose translocation in proteoliposomes reconstituted with lac carrier protein purified from Escherichia coli: 1. Effect of pH and imposed membrane potential on efflux, exchange, and counterflow
-
Garcia M.L., Viitanen P., Foster D.L., Kaback H.R. Mechanism of lactose translocation in proteoliposomes reconstituted with lac carrier protein purified from Escherichia coli: 1. Effect of pH and imposed membrane potential on efflux, exchange, and counterflow. Biochemistry 1983, 22:2524-2531.
-
(1983)
Biochemistry
, vol.22
, pp. 2524-2531
-
-
Garcia, M.L.1
Viitanen, P.2
Foster, D.L.3
Kaback, H.R.4
-
7
-
-
0018306535
-
Mechanism of lactose translocation in membrane vesicles from Escherichia coli: 1. Effect of pH on efflux, exchange, and counterflow
-
Kaczorowski G.J., Kaback H.R. Mechanism of lactose translocation in membrane vesicles from Escherichia coli: 1. Effect of pH on efflux, exchange, and counterflow. Biochemistry 1979, 18:3691-3697.
-
(1979)
Biochemistry
, vol.18
, pp. 3691-3697
-
-
Kaczorowski, G.J.1
Kaback, H.R.2
-
9
-
-
0041353145
-
Structure and mechanism of the lactose permease of Escherichia coli
-
Abramson J., Smirnova I., Kasho V., Verner G., Kaback H.R., Iwata S. Structure and mechanism of the lactose permease of Escherichia coli. Science 2003, 301:610-615.
-
(2003)
Science
, vol.301
, pp. 610-615
-
-
Abramson, J.1
Smirnova, I.2
Kasho, V.3
Verner, G.4
Kaback, H.R.5
Iwata, S.6
-
10
-
-
33645320817
-
Structural evidence for induced fit and a mechanism for sugar/H(+) symport in LacY
-
Mirza O., Guan L., Verner G., Iwata S., Kaback H.R. Structural evidence for induced fit and a mechanism for sugar/H(+) symport in LacY. EMBO J. 2006, 25:1177-1183.
-
(2006)
EMBO J.
, vol.25
, pp. 1177-1183
-
-
Mirza, O.1
Guan, L.2
Verner, G.3
Iwata, S.4
Kaback, H.R.5
-
11
-
-
34848888055
-
Structural determination of wild-type lactose permease
-
Guan L., Mirza O., Verner G., Iwata S., Kaback H.R. Structural determination of wild-type lactose permease. Proc. Natl Acad. Sci. USA 2007, 104:15294-15298.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 15294-15298
-
-
Guan, L.1
Mirza, O.2
Verner, G.3
Iwata, S.4
Kaback, H.R.5
-
12
-
-
33846277908
-
Site-directed alkylation and the alternating access model for LacY
-
Kaback H.R., Dunten R., Frillingos S., Venkatesan P., Kwaw I., Zhang W., Ermolova N. Site-directed alkylation and the alternating access model for LacY. Proc. Natl Acad. Sci. USA 2007, 104:491-494.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 491-494
-
-
Kaback, H.R.1
Dunten, R.2
Frillingos, S.3
Venkatesan, P.4
Kwaw, I.5
Zhang, W.6
Ermolova, N.7
-
13
-
-
34547880034
-
Single-molecule FRET reveals sugar-induced conformational dynamics in LacY
-
Majumdar D.S., Smirnova I., Kasho V., Nir E., Kong X., Weiss S., Kaback H.R. Single-molecule FRET reveals sugar-induced conformational dynamics in LacY. Proc. Natl Acad. Sci. USA 2007, 104:12640-12645.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 12640-12645
-
-
Majumdar, D.S.1
Smirnova, I.2
Kasho, V.3
Nir, E.4
Kong, X.5
Weiss, S.6
Kaback, H.R.7
-
14
-
-
36749074450
-
Sugar binding induces an outward facing conformation of LacY
-
Smirnova I., Kasho V., Choe J.Y., Altenbach C., Hubbell W.L., Kaback H.R. Sugar binding induces an outward facing conformation of LacY. Proc. Natl Acad. Sci. USA 2007, 104:16504-16509.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 16504-16509
-
-
Smirnova, I.1
Kasho, V.2
Choe, J.Y.3
Altenbach, C.4
Hubbell, W.L.5
Kaback, H.R.6
-
15
-
-
35548929298
-
Site-directed alkylation of LacY: effect of the proton electrochemical gradient
-
Nie Y., Ermolova N., Kaback H.R. Site-directed alkylation of LacY: effect of the proton electrochemical gradient. J. Mol. Biol. 2007, 374:356-364.
-
(2007)
J. Mol. Biol.
, vol.374
, pp. 356-364
-
-
Nie, Y.1
Ermolova, N.2
Kaback, H.R.3
-
16
-
-
44149122380
-
The Cys154→Gly mutation in LacY causes constitutive opening of the hydrophilic periplasmic pathway
-
Nie Y., Sabetfard F.E., Kaback H.R. The Cys154→Gly mutation in LacY causes constitutive opening of the hydrophilic periplasmic pathway. J. Mol. Biol. 2008, 379:695-703.
-
(2008)
J. Mol. Biol.
, vol.379
, pp. 695-703
-
-
Nie, Y.1
Sabetfard, F.E.2
Kaback, H.R.3
-
17
-
-
60749115991
-
Clogging the periplasmic pathway in LacY
-
Nie Y., Zhou Y., Kaback H.R. Clogging the periplasmic pathway in LacY. Biochemistry 2009, 48:738-743.
-
(2009)
Biochemistry
, vol.48
, pp. 738-743
-
-
Nie, Y.1
Zhou, Y.2
Kaback, H.R.3
-
18
-
-
70350553821
-
Residues gating the periplasmic pathway of LacY
-
Zhou Y., Nie Y., Kaback H.R. Residues gating the periplasmic pathway of LacY. J. Mol. Biol. 2009, 394:219-225.
-
(2009)
J. Mol. Biol.
, vol.394
, pp. 219-225
-
-
Zhou, Y.1
Nie, Y.2
Kaback, H.R.3
-
19
-
-
76049089794
-
Probing of the rates of alternating access in LacY with Trp fluorescence
-
Smirnova I., Kasho V., Sugihara J., Kaback H.R. Probing of the rates of alternating access in LacY with Trp fluorescence. Proc. Natl Acad. Sci. USA 2009, 106:21561-21566.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 21561-21566
-
-
Smirnova, I.1
Kasho, V.2
Sugihara, J.3
Kaback, H.R.4
-
20
-
-
0031029785
-
Cysteine-scanning mutagenesis of helix II and flanking hydrophilic domains in the lactose permease of Escherichia coli
-
Frillingos S., Sun J., Gonzalez A., Kaback H.R. Cysteine-scanning mutagenesis of helix II and flanking hydrophilic domains in the lactose permease of Escherichia coli. Biochemistry 1997, 36:269-273.
-
(1997)
Biochemistry
, vol.36
, pp. 269-273
-
-
Frillingos, S.1
Sun, J.2
Gonzalez, A.3
Kaback, H.R.4
-
21
-
-
0026660369
-
Membrane transport proteins: implications of sequence comparisons
-
Griffith J.K., Baker M.E., Rouch D.A., Page M.G., Skurray R.A., Paulsen I.T., et al. Membrane transport proteins: implications of sequence comparisons. Curr. Opin. Cell Biol. 1992, 4:684-695.
-
(1992)
Curr. Opin. Cell Biol.
, vol.4
, pp. 684-695
-
-
Griffith, J.K.1
Baker, M.E.2
Rouch, D.A.3
Page, M.G.4
Skurray, R.A.5
Paulsen, I.T.6
-
22
-
-
0028999357
-
The conserved motif, GXXX(D/E)(R/K)XG[X](R/K)(R/K), in hydrophilic loop 2/3 of the lactose permease
-
Jessen-Marshall A.E., Paul N.J., Brooker R.J. The conserved motif, GXXX(D/E)(R/K)XG[X](R/K)(R/K), in hydrophilic loop 2/3 of the lactose permease. J. Biol. Chem. 1995, 270:16251-16257.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 16251-16257
-
-
Jessen-Marshall, A.E.1
Paul, N.J.2
Brooker, R.J.3
-
23
-
-
0027087217
-
Insertional mutagenesis of hydrophilic domains in the lactose permease of Escherichia coli
-
McKenna E., Hardy D., Kaback H.R. Insertional mutagenesis of hydrophilic domains in the lactose permease of Escherichia coli. Proc. Natl Acad. Sci. USA 1992, 89:11954-11958.
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 11954-11958
-
-
McKenna, E.1
Hardy, D.2
Kaback, H.R.3
-
24
-
-
0028969580
-
Structural feature of the uniporter/symporter/antiporter superfamily
-
Goswitz V.C., Brooker R.J. Structural feature of the uniporter/symporter/antiporter superfamily. Protein Sci. 1995, 4:537-543.
-
(1995)
Protein Sci.
, vol.4
, pp. 537-543
-
-
Goswitz, V.C.1
Brooker, R.J.2
-
25
-
-
0030053616
-
Evidence that transmembrane segment 2 of the lactose permease is part of a conformationally sensitive interface between the two halves of the protein
-
Jessen-Marshall A.E., Brooker R.J. Evidence that transmembrane segment 2 of the lactose permease is part of a conformationally sensitive interface between the two halves of the protein. J. Biol. Chem. 1996, 271:1400-1404.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 1400-1404
-
-
Jessen-Marshall, A.E.1
Brooker, R.J.2
-
26
-
-
0030999256
-
Suppressor analysis of mutations in the loop 2-3 motif of lactose permease: evidence that glycine-64 is an important residue for conformational changes
-
Jessen-Marshall A.E., Parker N.J., Brooker R.J. Suppressor analysis of mutations in the loop 2-3 motif of lactose permease: evidence that glycine-64 is an important residue for conformational changes. J. Bacteriol. 1997, 179:2616-2622.
-
(1997)
J. Bacteriol.
, vol.179
, pp. 2616-2622
-
-
Jessen-Marshall, A.E.1
Parker, N.J.2
Brooker, R.J.3
-
27
-
-
4444221565
-
UCSF Chimera--a visualization system for exploratory research and analysis
-
Pettersen E.F., Goddard T.D., Huang C.C., Couch G.S., Greenblatt D.M., Meng E.C., Ferrin T.E. UCSF Chimera--a visualization system for exploratory research and analysis. J. Comput. Chem. 2004, 25:1605-1612.
-
(2004)
J. Comput. Chem.
, vol.25
, pp. 1605-1612
-
-
Pettersen, E.F.1
Goddard, T.D.2
Huang, C.C.3
Couch, G.S.4
Greenblatt, D.M.5
Meng, E.C.6
Ferrin, T.E.7
-
28
-
-
0029988250
-
A general method for determining helix packing in membrane proteins in situ: helices I and II are close to helix VII in the lactose permease of Escherichia coli
-
Wu J., Kaback H.R. A general method for determining helix packing in membrane proteins in situ: helices I and II are close to helix VII in the lactose permease of Escherichia coli. Proc. Natl. Acad. Sci. USA 1996, 93:14498-14502.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 14498-14502
-
-
Wu, J.1
Kaback, H.R.2
-
29
-
-
0030747620
-
Helix proximity and ligand-induced conformational changes in the lactose permease of Escherichia coli determined by site-directed chemical crosslinking
-
Wu J., Kaback H.R. Helix proximity and ligand-induced conformational changes in the lactose permease of Escherichia coli determined by site-directed chemical crosslinking. J. Mol. Biol. 1997, 270:285-293.
-
(1997)
J. Mol. Biol.
, vol.270
, pp. 285-293
-
-
Wu, J.1
Kaback, H.R.2
-
30
-
-
0032506162
-
Tilting of helix I and ligand-induced changes in the lactose permease determined by site-directed chemical crosslinking in situ
-
Wu J., Hardy D., Kaback H.R. Tilting of helix I and ligand-induced changes in the lactose permease determined by site-directed chemical crosslinking in situ. Biochemistry 1998, 37:15785-15790.
-
(1998)
Biochemistry
, vol.37
, pp. 15785-15790
-
-
Wu, J.1
Hardy, D.2
Kaback, H.R.3
-
31
-
-
0032500626
-
Transmembrane helix tilting and ligand-induced conformational changes in the lactose permease determined by site-directed chemical crosslinking in situ
-
Wu J., Hardy D., Kaback H.R. Transmembrane helix tilting and ligand-induced conformational changes in the lactose permease determined by site-directed chemical crosslinking in situ. J. Mol. Biol. 1998, 282:959-967.
-
(1998)
J. Mol. Biol.
, vol.282
, pp. 959-967
-
-
Wu, J.1
Hardy, D.2
Kaback, H.R.3
-
32
-
-
0033010801
-
Site-directed chemical cross-linking demonstrates that helix IV is close to helices VII and XI in the lactose permease
-
Wu J., Hardy D., Kaback H.R. Site-directed chemical cross-linking demonstrates that helix IV is close to helices VII and XI in the lactose permease. Biochemistry 1999, 38:1715-1720.
-
(1999)
Biochemistry
, vol.38
, pp. 1715-1720
-
-
Wu, J.1
Hardy, D.2
Kaback, H.R.3
-
33
-
-
0033596695
-
Tertiary contacts of helix V in the lactose permease determined by site-directed chemical cross-linking in situ
-
Wu J., Hardy D., Kaback H.R. Tertiary contacts of helix V in the lactose permease determined by site-directed chemical cross-linking in situ. Biochemistry 1999, 38:2320-2325.
-
(1999)
Biochemistry
, vol.38
, pp. 2320-2325
-
-
Wu, J.1
Hardy, D.2
Kaback, H.R.3
-
34
-
-
0033588117
-
Proximity relationships between helices I and XI or XII in the lactose permease of Escherichia coli determined by site-directed thiol cross-linking
-
Wang Q., Kaback H.R. Proximity relationships between helices I and XI or XII in the lactose permease of Escherichia coli determined by site-directed thiol cross-linking. J. Mol. Biol. 1999, 291:683-692.
-
(1999)
J. Mol. Biol.
, vol.291
, pp. 683-692
-
-
Wang, Q.1
Kaback, H.R.2
-
35
-
-
0026757193
-
Possible salt bridges between transmembrane alpha-helices of the lactose carrier of Escherichia coli
-
Lee J.I., Hwang P.P., Hansen C., Wilson T.H. Possible salt bridges between transmembrane alpha-helices of the lactose carrier of Escherichia coli. J. Biol. Chem. 1992, 267:20758-20764.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 20758-20764
-
-
Lee, J.I.1
Hwang, P.P.2
Hansen, C.3
Wilson, T.H.4
-
36
-
-
0026439214
-
Functional interactions between putative intramembrane charged residues in the lactose permease of Escherichia coli
-
Sahin-Toth M., Dunten R.L., Gonzalez A., Kaback H.R. Functional interactions between putative intramembrane charged residues in the lactose permease of Escherichia coli. Proc. Natl Acad. Sci. USA 1992, 89:10547-10551.
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 10547-10551
-
-
Sahin-Toth, M.1
Dunten, R.L.2
Gonzalez, A.3
Kaback, H.R.4
-
37
-
-
41649112580
-
Opening and closing of the periplasmic gate in lactose permease
-
Zhou Y., Guan L., Freites J.A., Kaback H.R. Opening and closing of the periplasmic gate in lactose permease. Proc. Natl Acad. Sci. USA 2008, 105:3774-3778.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 3774-3778
-
-
Zhou, Y.1
Guan, L.2
Freites, J.A.3
Kaback, H.R.4
-
38
-
-
0027419744
-
Role of the charge pair formed by aspartic acid 237 and lysine 358 in the lactose permease of Escherichia coli
-
Dunten R.L., Sahin-Tóth M., Kaback H.R. Role of the charge pair formed by aspartic acid 237 and lysine 358 in the lactose permease of Escherichia coli. Biochemistry 1993, 32:3139-3145.
-
(1993)
Biochemistry
, vol.32
, pp. 3139-3145
-
-
Dunten, R.L.1
Sahin-Tóth, M.2
Kaback, H.R.3
-
39
-
-
0026087282
-
The interaction between aspartic acid 237 and lysine 358 in the lactose carrier of Escherichia coli
-
King S.C., Hansen C.L., Wilson T.H. The interaction between aspartic acid 237 and lysine 358 in the lactose carrier of Escherichia coli. Biochim. Biophys. Acta 1991, 1062:177-186.
-
(1991)
Biochim. Biophys. Acta
, vol.1062
, pp. 177-186
-
-
King, S.C.1
Hansen, C.L.2
Wilson, T.H.3
-
40
-
-
0027203537
-
Lysine 319 interacts with both glutamic acid 269 and aspartic acid 240 in the lactose carrier of Escherichia coli
-
Lee J.I., Hwang P.P., Wilson T.H. Lysine 319 interacts with both glutamic acid 269 and aspartic acid 240 in the lactose carrier of Escherichia coli. J. Biol. Chem. 1993, 268:20007-20015.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 20007-20015
-
-
Lee, J.I.1
Hwang, P.P.2
Wilson, T.H.3
-
41
-
-
0027382884
-
Properties of interacting aspartic acid and lysine residues in the lactose permease of Escherichia coli
-
Sahin-Tóth M., Kaback H.R. Properties of interacting aspartic acid and lysine residues in the lactose permease of Escherichia coli. Biochemistry 1993, 32:10027-10035.
-
(1993)
Biochemistry
, vol.32
, pp. 10027-10035
-
-
Sahin-Tóth, M.1
Kaback, H.R.2
-
42
-
-
70349624841
-
Properties of a LacY efflux mutant
-
Guan L., Kaback H.R. Properties of a LacY efflux mutant. Biochemistry 2009, 48:9250-9255.
-
(2009)
Biochemistry
, vol.48
, pp. 9250-9255
-
-
Guan, L.1
Kaback, H.R.2
-
43
-
-
77957978298
-
-
LacY Ec: Lactose permease, E. coli (P02920); LacY Yp: Lactose permease, Y. pestis (AAM86136); LacY Cf: Lactose permease, C. freundii (P47234); LacY Ko: Lactose permease, K. oxitoca (P18817); RafB Ec: Raffinose permease, E. coli (P16552); FruP Ec: Fructose permease, B. megaterium (AAM19070); MelY, Ecl: Melibiose transporter, Enterobacter cloacae (BAA19154); CscG Ec: Sucrose permease, E. coli (P3000
-
LacY Ec: Lactose permease, E. coli (P02920); LacY Yp: Lactose permease, Y. pestis (AAM86136); LacY Cf: Lactose permease, C. freundii (P47234); LacY Ko: Lactose permease, K. oxitoca (P18817); RafB Ec: Raffinose permease, E. coli (P16552); FruP Ec: Fructose permease, B. megaterium (AAM19070); MelY, Ecl: Melibiose transporter, Enterobacter cloacae (BAA19154); CscG Ec: Sucrose permease, E. coli (P30000).
-
-
-
-
44
-
-
33845917073
-
Energetics of ligand-induced conformational flexibility in the lactose permease of Escherichia coli
-
Nie Y., Smirnova I., Kasho V., Kaback H.R. Energetics of ligand-induced conformational flexibility in the lactose permease of Escherichia coli. J. Biol. Chem. 2006, 281:35779-35784.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 35779-35784
-
-
Nie, Y.1
Smirnova, I.2
Kasho, V.3
Kaback, H.R.4
-
45
-
-
0025865318
-
Role of proline residues in the structure and function of a membrane transport protein
-
Consler T.G., Tsolas O., Kaback H.R. Role of proline residues in the structure and function of a membrane transport protein. Biochemistry 1991, 30:1291-1298.
-
(1991)
Biochemistry
, vol.30
, pp. 1291-1298
-
-
Consler, T.G.1
Tsolas, O.2
Kaback, H.R.3
-
46
-
-
77957010716
-
Bacterial membranes
-
Elsevier, New York, NY, N.P. Kaplan, W.B. Jakoby, N.P. Colowick (Eds.)
-
Kaback H.R. Bacterial membranes. Methods in Enzymology 1971, vol. XXII:99-120. Elsevier, New York, NY. N.P. Kaplan, W.B. Jakoby, N.P. Colowick (Eds.).
-
(1971)
Methods in Enzymology
, vol.22
, pp. 99-120
-
-
Kaback, H.R.1
-
47
-
-
0016750458
-
Localization of d-lactate dehydrogenase in native and reconstituted Escherichia coli membrane vesicles
-
Short S.A., Kaback H.R., Kohn L.D. Localization of d-lactate dehydrogenase in native and reconstituted Escherichia coli membrane vesicles. J. Biol. Chem. 1975, 250:4291-4296.
-
(1975)
J. Biol. Chem.
, vol.250
, pp. 4291-4296
-
-
Short, S.A.1
Kaback, H.R.2
Kohn, L.D.3
-
48
-
-
0021275924
-
Intramolecular dislocation of the COOH terminus of the lac carrier protein in reconstituted proteoliposomes
-
Carrasco N., Herzlinger D., Mitchell R., DeChiara S., Danho W., Gabriel T.F., Kaback H.R. Intramolecular dislocation of the COOH terminus of the lac carrier protein in reconstituted proteoliposomes. Proc. Natl Acad. Sci. USA 1984, 81:4672-4676.
-
(1984)
Proc. Natl Acad. Sci. USA
, vol.81
, pp. 4672-4676
-
-
Carrasco, N.1
Herzlinger, D.2
Mitchell, R.3
DeChiara, S.4
Danho, W.5
Gabriel, T.F.6
Kaback, H.R.7
-
49
-
-
0016321695
-
Transport in isolated bacterial membrane vesicles
-
Kaback H.R. Transport in isolated bacterial membrane vesicles. Methods Enzymol. 1974, 31:698-709.
-
(1974)
Methods Enzymol.
, vol.31
, pp. 698-709
-
-
Kaback, H.R.1
-
50
-
-
0017096461
-
Equilibrium between two forms of the lac carrier protein in energized and nonenergized membrane vesicles from Escherichia coli
-
Rudnick G., Schuldiner S., Kaback H.R. Equilibrium between two forms of the lac carrier protein in energized and nonenergized membrane vesicles from Escherichia coli. Biochemistry 1976, 15:5126-5131.
-
(1976)
Biochemistry
, vol.15
, pp. 5126-5131
-
-
Rudnick, G.1
Schuldiner, S.2
Kaback, H.R.3
|