Inhibition of AcpA phosphatase activity with ascorbate attenuates Francisella tularensis intramacrophage survival

Journal of Biological Chemistry

Volumn 285, Issue 8, 2010, Pages 5171-5177

  McRae, Steven ^a,c   Pagliai, Fernando A ^a   Mohapatra, Nrusingh P ^b   Gener, Alejandro ^a,c   Mahmou, Asma Sayed Abdelgeliel ^a   Gunn, John S ^b   Lorca, Graciela L ^a   Gonzalez, Claudio F ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE; FRANCISELLA TULARENSIS; HOST CELLS; IN-VITRO; INFECTED CELLS; INHIBITORY COMPOUNDS; INTRACELLULAR PATHOGENS; KNOCKOUT STRAINS; PHOSPHATASE ACTIVITY; SITE DIRECTED MUTAGENESIS;

ACIDS; ENZYME ACTIVITY;

PHOSPHATASES;

2 PHOSPHOASCORBATE; ACID PHOSPHATASE; ASCORBIC ACID; ASCORBIC ACID DERIVATIVE; UNCLASSIFIED DRUG; ANTIOXIDANT; BACTERIAL PROTEIN; PHOSPHATASE;

ARTICLE; BACTERIAL SURVIVAL; BIOASSAY; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; FRANCISELLA TULARENSIS; HOST CELL; IN VITRO STUDY; MACROPHAGE; MOLECULAR LIBRARY; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; TULAREMIA; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE DELETION; GENETICS; METABOLISM; MICROBIAL VIABILITY; MICROBIOLOGY; MOUSE; PHYSIOLOGY;

FRANCISELLA TULARENSIS;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BACTERIAL PROTEINS; CATALYTIC DOMAIN; FRANCISELLA TULARENSIS; GENE DELETION; MACROPHAGES; MICE; MICROBIAL VIABILITY; PHOSPHORIC MONOESTER HYDROLASES;

EID: 77949328588     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.039511     Document Type: Article

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