Ketopinic acid derived bis(hydroxy amides) as cheap, chiral ligands for the enantioselective ethylation of aromatic aldehydes

European Journal of Organic Chemistry

Volumn , Issue 9, 2010, Pages 1717-1727

  De Las Casas Engel, Tomás ^a   Maroto, Beatriz Lora ^a   De La Moya Cerero, Santiago ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Asymmetric catalysis; Chiral pool; Hydroxy amides; Structure activity relationships; Zinc

Indexed keywords

EID: 77949300467     PISSN: 1434193X     EISSN: 10990690     Source Type: Journal    
DOI: 10.1002/ejoc.200901391     Document Type: Article

References (67)

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65. Note that the formation of an N-coordinated, zinc-centered complex (-CO-N-Zn-N-CO-) from a 2-carbon-spacer bis(hydroxy amide) should involve a rigid five-membered-ring spacer, whereas the carbonyl-chelated one (-N-C=O-Zn-O=C-N-) involves a less rigid, eight-membered-ring spacer.
66. The reduction of the ligand loading results in the different behavior of these diastereomeric ligands (see Table 4).
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