Influence of neuregulin1 genotype on neural substrate of perceptual matching in children

Behavior Genetics

Volumn 40, Issue 2, 2010, Pages 157-166

  Mechelli, Andrea ^a   Viding, Essi ^a,b   Kumar, Atul ^a   Tognin, Stefania ^a   Kane, Fergus ^a   McGuire, Philip ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Bipolar disorder; Childhood; Functional magnetic resonance imaging; Neuregulin1; Perceptual matching; Schizophrenia

Indexed keywords

NEU DIFFERENTIATION FACTOR;

ARTICLE; BIPOLAR DISORDER; BRAIN FUNCTION; BRAIN REGION; CAUDATE NUCLEUS; CHILD; CINGULATE GYRUS; CONTROLLED STUDY; DIZYGOTIC TWINS; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOZYGOTIC TWINS; NERVE CELL NETWORK; OCCIPITAL LOBE; PERCEPTION; SCHIZOPHRENIA; SCHOOL CHILD; TASK PERFORMANCE;

ALLELES; BEHAVIOR; BRAIN MAPPING; CHILD; GENOTYPE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; NEUREGULIN-1; REPRODUCIBILITY OF RESULTS; RISK; SCHIZOPHRENIA; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC;

EID: 77949275825     PISSN: 00018244     EISSN: 15733297     Source Type: Journal    
DOI: 10.1007/s10519-009-9317-5     Document Type: Article

References (55)

1. AM Addington MC Gornick P Shaw J Seal N Gogtay D Greenstein, et al. 2007 Neuregulin 1 (8p12) and childhood-onset schizophrenia: susceptibility haplotypes for diagnosis and brain developmental trajectories Mol Psychiatry 12 2 195 205 10.1038/sj.mp.4001906 17033632 (Pubitemid 46160984)
2. T Bitan J Cheon D Lu DD Burman JR Booth 2009 Developmental increase in top-down and bottom-up processing in a phonological task: an effective connectivity, fMRI study J Cogn Neurosci 21 6 1135 1145 10.1162/jocn.2009.21065 18702576
3. ED Burgund HC Kang JE Kelly RL Buckner AZ Snyder SE Petersen, et al. 2002 The feasibility of a common stereotactic space for children and adults in fMRI studies of development Neuroimage 17 1 184 200 10.1006/nimg.2002.1174 12482076
4. PD Butler DC Javitt 2005 Early-stage visual processing deficits in schizophrenia Curr Opin Psychiatry 18 2 151 157 10.1097/00001504-200503000-00008 16639168
5. PD Butler V Zemon I Schechter AM Saperstein MJ Hoptman KO Lim, et al. 2005 Early-stage visual processing and cortical amplification deficits in schizophrenia Arch Gen Psychiatry 62 5 495 504 10.1001/archpsyc.62.5.495 15867102 (Pubitemid 40628878)
6. A Caspi TE Moffitt 2006 Gene-environment interactions in psychiatry: joining forces with neuroscience Nat Rev Neurosci 7 7 583 590 10.1038/nrn1925 16791147 Review (Pubitemid 43995433)
7. AE Cavanna MR Trimble 2006 The precuneus: a review of its functional anatomy and behavioural correlates Brain 129 Pt 3 564 583 10.1093/brain/awl004 16399806 Review (Pubitemid 43278220)
8. G Corfas K Roy JD Buxbaum 2004 Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia Nat Neurosci 7 575 580 10.1038/nn1258 15162166 (Pubitemid 38691892)
9. N Craddock MC O'Donovan MJ Owen 2007 Phenotypic and genetic complexity of psychosis. Invited commentary on Schizophrenia: a common disease caused by multiple rare alleles Br J Psychiatry 190 200 203 10.1192/bjp.bp.106.033761 17329738 (Pubitemid 46384002)
10. D Curtis K Xu 2007 Minor differences in haplotype frequency estimates can produce very large differences in heterogeneity test statistics BMC Genet 8 38 10.1186/1471-2156-8-38 17597526 (Pubitemid 47086724)
11. Diggle PJ, Heagerty P, Liang K-Y, Zeger SL (2002) Analysis of longitudinal data, 2nd edn. Oxford University Press, Oxford, pp 70-80
12. DL Falls 2003 Neuregulins: functions, forms, and signaling strategies Exp Cell Res 284 1 14 30 10.1016/S0014-4827(02)00102-7 12648463 Review (Pubitemid 36335807)
13. PM Fisher KE Muñoz AR Hariri 2008 Identification of neurogenetic pathways of risk for psychopathology Am J Med Genet C Semin Med Genet 148 2 147 153 Review
14. B Freeman N Smith C Curtis L Huckett J Mill IW Craig 2003 DNA from buccal swabs recruited by mail: evaluation of storage effects on long-term stability and suitability for multiplex polymerase chain reaction genotyping Behav Genet 33 1 67 72 10.1023/A:1021055617738 12645823 (Pubitemid 36176783)
15. Friston KJ (2003) Introduction: experimental design and statistical parametric mapping. In: Frackowiak RSJ, Friston KJ, Frith C, Dolan R, Friston KJ, Price CJ, Zeki S, Ashburner J, Penny WD (eds) Human brain function. Academic Press, London, pp 599-632
16. R Goodman T Ford H Simmons R Gatward H Meltzer 2000 Using the strengths and difficulties questionnaire (SDQ) to screen for child psychiatric disorders in a community sample Br J Psychiatry 177 534 539 10.1192/bjp.177.6.534 11102329 (Pubitemid 32005485)
17. EK Green R Raybould S Macgregor K Gordon-Smith J Heron S Hyde, et al. 2005 Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder Arch Gen Psychiatry 62 6 642 648 10.1001/archpsyc.62.6.642 15939841 (Pubitemid 40973439)
18. J Hall HC Whalley DE Job BJ Baig AM McIntosh KL Evans, et al. 2006 A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms Nat Neurosci 9 1477 1478 10.1038/nn1795 17072305 (Pubitemid 44862654)
19. AR Hariri DR Weinberger 2003 Imaging genomics Br Med Bull 65 259 270 10.1093/bmb/65.1.259 12697630 (Pubitemid 36406471)
20. M Ikeda N Takahashi S Saito B Aleksic Y Watanabe A Nunokawa, et al. 2008 Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample Schizophr Res 101 1-3 1 8 10.1016/j.schres.2008.01.010 18282690
21. AP Jones KR Laurens CM Herba GJ Barker E Viding 2009 Amygdala hypoactivity to fearful faces in boys with conduct problems and callous-unemotional traits Am J Psychiatry 166 1 95 102 10.1176/appi.ajp.2008. 07071050 18923070
22. HC Kang ED Burgund HM Lugar SE Petersen BL Schlaggar 2003 Comparison of functional activation foci in children and adults using a common stereotactic space Neuroimage 19 1 16 28 12781724
23. MS Keshavan VA Diwadkar DM Montrose R Rajarethinam JA Sweeney 2005 Premorbid indicators and risk for schizophrenia: a selective review and update Schizophr Res 79 1 45 57 10.1016/j.schres.2005.07.004 16139479 Review (Pubitemid 41363765)
24. J Kim-Cohen A Caspi TE Moffitt H Harrington BJ Milne R Poulton 2003 Prior juvenile diagnoses in adults with mental disorder: developmental follow-back of a prospective-longitudinal cohort Arch Gen Psychiatry 60 7 709 717 10.1001/archpsyc.60.7.709 12860775 (Pubitemid 36818633)
25. T Kircher R Thienel M Wagner M Reske U Habel T Kellermann, et al. 2009 Neuregulin 1 ICE-single nucleotide polymorphism in first episode schizophrenia correlates with cerebral activation in fronto-temporal areas Eur Arch Psychiatry Clin Neurosci 259 2 72 79 10.1007/s00406-008-0837-4 18806920
26. L Krabbendam B Arts J van Os A Aleman 2005 Cognitive functioning in patients with schizophrenia and bipolar disorder: a quantitative review Schizophr Res 80 2-3 137 149 10.1016/j.schres.2005.08.004 16183257 (Pubitemid 41713640)
27. A Krug V Markov T Eggermann S Krach K Zerres T Stöcker, et al. 2008 Genetic variation in the schizophrenia-risk gene neuregulin1 correlates with differences in frontal brain activation in a working memory task in healthy individuals Neuroimage 42 4 1569 1576 10.1016/j.neuroimage.2008.05.058 18606232
28. Lang PJ, Bradley MM, Cuthbert BN (2005) International affective picture system (IAPS): affective ratings of pictures and instruction manual (tech report A-6). University of Florida, Center for Research in Psychophysiology, Gainesville
29. AJ Law BK Lipska CS Weickert TM Hyde RE Straub R Hashimoto, et al. 2006 Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5′ SNPs associated with the disease Proc Natl Acad Sci USA 103 17 6747 6752 10.1073/pnas.0602002103 16618933
30. D Li DA Collier L He 2006 Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene in schizophrenia Human Mol Genet 15 12 1995 2002 10.1093/hmg/ddl122 (Pubitemid 43983273)
31. B Li RS Woo L Mei R Malinow 2007 The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity Neuron 54 4 583 597 10.1016/j.neuron.2007.03.028 17521571 (Pubitemid 46756136)
32. AA Marsh EC Finger DG Mitchell ME Reid C Sims DS Kosson, et al. 2008 Reduced amygdala response to fearful expressions in children and adolescents with callous-unemotional traits and disruptive behavior disorders Am J Psychiatry 165 6 712 720 10.1176/appi.ajp.2007.07071145 18281412 (Pubitemid 351810540)
33. A Martínez SA Hillyard EC Dias DJ Hagler Jr PD Butler DN Guilfoyle, et al. 2008 Magnocellular pathway impairment in schizophrenia: evidence from functional magnetic resonance imaging J Neurosci 28 30 7492 7500 10.1523/JNEUROSCI.1852-08.2008 18650327
34. AM McIntosh TW Moorhead D Job GK Lymer S Muñoz Maniega J McKirdy, et al. 2007 The effects of a neuregulin 1 variant on white matter density and integrity Mol Psychiatry 13 11 1054 1059 10.1038/sj.mp.4002103 17925794
35. A Mechelli RN Henson CJ Price KJ Friston 2003 Comparing event-related and epoch analysis in blocked design fMRI Neuroimage 18 3 806 810 10.1016/S1053-8119(02)00027-7 12667857 (Pubitemid 36349430)
36. A Mechelli DP Prata CH Fu M Picchioni F Kane S Kalidindi, et al. 2008 The effects of neuregulin1 on brain function in controls and patients with schizophrenia and bipolar disorder Neuroimage 42 2 817 826 10.1016/j.neuroimage. 2008.05.025 18585932
37. FA Middleton PL Strick 1994 Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function Science 266 458 461 10.1126/science.7939688 7939688
38. V Moskvina KM Schmidt 2006 Susceptibility of biallelic haplotype and genotype frequencies to genotyping error Biometrics 62 4 1116 1123 10.1111/j.1541-0420.2006.00563.x 17156286 (Pubitemid 44915533)
39. J Nierenberg DF Salisbury JJ Levitt EA David RW McCarley ME Shenton 2005 Reduced left angular gyrus volume in first-episode schizophrenia Am J Psychiatry 162 8 1539 1541 10.1176/appi.ajp.162.8.1539 16055780 (Pubitemid 41105573)
40. CM O'Tuathaigh AM O'Connor GJ O'Sullivan D Lai R Harvey DT Croke JL Waddington 2008 Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous 'knockout' of the schizophrenia risk gene neuregulin-1 Prog Neuropsychopharmacol Biol Psychiatry 32 2 462 466 10.1016/j.pnpbp.2007.09.018 17980471 (Pubitemid 351178964)
41. MP Paulus NE Hozack BE Zauscher L Frank GG Brown J McDowell DL Braff 2002 Parietal dysfunction is associated with increased outcome-related decision-making in schizophrenia patients Biol Psychiatry 51 12 995 1004 10.1016/S0006-3223(01)01358-0 12062884 (Pubitemid 34607717)
42. K Pauly NY Seiferth T Kellermann V Backes TD Vloet NJ Shah, et al. 2008 Cerebral dysfunctions of emotion-cognition interactions in adolescent-onset schizophrenia J Am Acad Child Adolesc Psychiatry 47 11 1299 1310 10.1097/CHI.0b013e318184ff16 18827725
43. Penny WD, Holmes A (2003) Random effects analysis. In: Frackowiak RSJ, Friston KJ, Frith C, Dolan R, Friston KJ, Price CJ, Zeki S, Ashburner J, Penny WD (eds) Human brain function. Academic Press, London, pp 843-850
44. M Raemaekers NF Ramsey M Vink MP van den Heuvel RS Kahn 2006 Brain activation during antisaccades in unaffected relatives of schizophrenic patients Biol Psychiatry 59 6 530 535 10.1016/j.biopsych.2005.07.030 16165103 (Pubitemid 43320541)
45. R Rajarethinam A Upadhyaya P Tsou M Upadhyaya MS Keshavan 2007 Caudate volume in offspring of patients with schizophrenia Br J Psychiatry 191 258 259 10.1192/bjp.bp.106.029017 17766768 (Pubitemid 47435058)
46. I Schechter PD Butler G Silipo V Zemon DC Javitt 2003 Magnocellular and parvocellular contributions to backward masking dysfunction in schizophrenia Schizopr Res 64 2-3 91 101 10.1016/S0920-9964(03)00008-2 (Pubitemid 37412331)
47. H Stefansson E Sigurdsson V Steinthorsdottir S Bjornsdottir T Sigmundsson S Ghosh, et al. 2002 Neuregulin 1 and susceptibility to schizophrenia Am J Hum Genet 71 877 892 10.1086/342734 12145742
48. H Stefansson J Sarginson A Kong P Yates V Steinthorsdottir E Gudfinnsson, et al. 2003 Association of neuregulin 1 with schizophrenia confirmed in a Scottish population Am J Hum Genet 72 1 83 87 10.1086/345442 12478479 (Pubitemid 36056844)
49. V Steinthorsdottir H Stefansson S Ghosh B Birgisdottir S Bjornsdottir AC Fasquel, et al. 2004 Multiple novel transcription initiation sites for NRG1 Gene 342 1 97 105 10.1016/j.gene.2004.07.029 15527969 (Pubitemid 39457182)
50. PA Thomson A Christoforou SW Morris E Adie BS Pickard DJ Porteous, et al. 2007 Association of Neuregulin 1 with schizophrenia and bipolar disorder in a second cohort from the Scottish population Mol Psychiatry 12 1 94 104 10.1038/sj.mp.4001889 16940976 (Pubitemid 44973666)
51. S Tosato P Dazzan D Collier 2005 Association between the neuregulin 1 gene and schizophrenia: a systematic review Schizophr Bull 31 613 617 10.1093/schbul/sbi043 16081509 (Pubitemid 41253313)
52. E Viding DE Williamson AR Hariri 2006 Developmental imaging genetics: challenges and promises for translational research Dev Psychopathol 18 3 877 892 10.1017/S0954579406060433 17152405 Review (Pubitemid 44445166)
53. Wechsler D (1999) Wechsler abbreviated scale of intelligence. Psychological Corporation, San Antonio, TX
54. DR Weinberger 1987 Implications of normal brain development for the pathogenesis of schizophrenia Arch Gen Psychiatry 44 7 660 669 3606332
55. RS Woo XM Li Y Tao E Carpenter-Hyland YZ Huang J Weber, et al. 2007 Neuregulin-1 enhances depolarization-induced GABA release Neuron 54 4 599 610 10.1016/j.neuron.2007.04.009 17521572 (Pubitemid 46756135)