In vitro and in vivo antitumor effects of novel actinomycin D analogs with amino acid substituted in the cyclic depsipeptides

Peptides

Volumn 31, Issue 4, 2010, Pages 568-573

  Zhang, Bang zhi ^a   Wang, Kai rong ^a   Yan, Jie xi ^a   Zhang, Wei ^a   Song, Jing jing ^a   Ni, Jing man ^b   Wang, Rui ^a  

^a Institute of Biochemistry and Molecular Biology   (China)

^b LANZHOU UNIVERSITY   (China)

Author keywords

Actinomycin D; Acute toxicity; Amino acid; Analogs; Antitumor; Cytotoxic activity

Indexed keywords

ACTINOMYCIN D [2 DEXTRO PHENYLALANINE 5 DEXTRO METHYLALANINE]; ACTINOMYCIN D [2 DEXTRO PHENYLALANINE 5 DEXTRO METHYLISOLEUCINE]; ACTINOMYCIN D [2 DEXTRO PHENYLALANINE 5 DEXTRO METHYLLEUCINE]; ACTINOMYCIN D [2 DEXTRO PHENYLALANINE 5 DEXTRO METHYLPHENYLALANINE]; ACTINOMYCIN D [2 DEXTRO PHENYLALANINE 5 DEXTRO METHYLVALINE]; ACTINOMYCIN D [2 DEXTRO PHENYLALANINE 5 METHYLLEUCINE]; ACTINOMYCIN D [2 DEXTRO PHENYLALANINE 5 METHYLPHENYLALANINE]; ACTINOMYCIN D [2 DEXTRO PHENYLALANINE 5 SARCOSINE]; ACTINOMYCIN D [2 DEXTRO VALINE 5 DEXTRO METHYLLEUCINE]; ACTINOMYCIN D [2 DEXTRO VALINE 5 METHYLISOLEUCINE]; ACTINOMYCIN D [2 DEXTRO VALINE 5 METHYLLEUCINE]; ACTINOMYCIN D [2 DEXTRO VALINE 5 METHYLVALINE]; ACTINOMYCIN D [2 DEXTRO VALINE 5 SARCOSINE]; AMINO ACID; ANTINEOPLASTIC ANTIBIOTIC; CYCLODEPSIPEPTIDE; DACTINOMYCIN; DACTINOMYCIN DERIVATIVE; DEXTRO PHENYLALANINE; N METHYLALANINE; N METHYLISOLEUCINE; N METHYLLEUCINE; N METHYLPHENYLALANINE; N METHYLVALINE; SARCOSINE; UNCLASSIFIED DRUG; VALINE;

ACUTE TOXICITY; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG POTENCY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; LD 50; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; SARCOMA 180; SINGLE DRUG DOSE; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; AMINO ACIDS; ANIMALS; ANTI-INFECTIVE AGENTS; ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; DACTINOMYCIN; DEPSIPEPTIDES; DNA FRAGMENTATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE;

MUS;

EID: 77949270725     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2009.12.024     Document Type: Article

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