Antibacterial activity of radical scavengers against class Ib ribonucleotide reductase from Bacillus anthracis

Biological Chemistry

Volumn 391, Issue 2-3, 2010, Pages 229-234

  Torrents, Eduard ^a,b   Sjöberg, Britt Marie ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b INSTITUTE FOR BIOENGINEERING OF CATALONIA IBEC   (Spain)

Author keywords

Anthrax; Antibacterial drug; Antibacterial target; Enzyme inhibition

Indexed keywords

RIBONUCLEOTIDE REDUCTASE; RIBONUCLEOTIDE REDUCTASE IB; SCAVENGER; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS ANTHRACIS; BACTERIAL GROWTH; BACTERIAL INFECTION; CELL PROLIFERATION; DNA REPAIR; DNA REPLICATION; ENZYME INHIBITION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SPORE GERMINATION;

ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; BLOTTING, WESTERN; FREE RADICAL SCAVENGERS; GENE EXPRESSION PROFILING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBONUCLEOTIDE REDUCTASES;

BACILLUS ANTHRACIS; MAMMALIA;

EID: 77749343089     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2010.017     Document Type: Article

References (32)

1. Baichoo, N., Wang, T., Ye, R., and Helmann, J.D. (2002). Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon. Mol. Microbiol. 45, 1613-1629.
2. Bergman, N.H., Anderson, E.C., Swenson, E.E., Niemeyer, M.M., Miyoshi, A.D., and Hanna, P.C. (2006). Transcriptional profiling of the Bacillus anthracis life cycle in vitro and an implied model for regulation of spore formation. J. Bacteriol. 188, 6092-6100.
3. Bergman, N.H., Anderson, E.C., Swenson, E.E., Janes, B.K., Fisher, N., Niemeyer, M.M., Miyoshi, A.D., and Hanna, P.C. (2007). Transcriptional profiling of Bacillus anthracis during infection of host macrophages. Infect. Immun. 75, 3434-3444.
4. Cendrowski, S., MacArthur, W., and Hanna, P. (2004). Bacillus anthracis requires siderophore biosynthesis for growth in mac-rophages and mouse virulence. Mol. Microbiol. 51, 407-417.
5. Cotruvo, J.A., Jr. and Stubbe, J. (2008). NrdI, a flavodoxin involved in maintenance of the diferric-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase. Proc. Natl. Acad. Sci. USA 105, 14383-14388.
6. Crawford, M.J. and Goldberg, D.E. (1998). Regulation of the Salmonella typhimurium flavohemoglobin gene. A new pathway for bacterial gene expression in response to nitric oxide. J. Biol. Chem. 273, 34028-34032.
7. Gat, O., Mendelson, I., Chitlaru, T., Ariel, N., Altboum, Z., Levy, H., Weiss, S., Grosfeld, H., Cohen, S., and Shafferman, A. (2005). The solute-binding component of a putative Mn(II) ABC transporter (MntA) is a novel Bacillus anthracis virulence determinant. Mol. Microbiol. 58, 533-551.
8. Guidi-Rontani, C. (2002). The alveolar macrophage: the Trojan horse of Bacillus anthracis. Trends Microbiol. 10, 405-409.
9. Hantke, K. (1988). Characterization of an iron sensitive Mud1 mutant in E. coli lacking the ribonucleotide reductase subunit B2. Arch. Microbiol. 149, 344-349.
10. Hantke, K. (2001). Iron and metal regulation in bacteria. Curr. Opin. Microbiol. 4, 172-177.
11. Herbig, A.F. and Helmann, J.D. (2001). Roles of metal ions and hydrogen peroxide in modulating the interaction of the Bacillus subtilis PerR peroxide regulon repressor with operator DNA. Mol. Microbiol. 41, 849-859.
12. Horsburgh, M.J., Clements, M.O., Crossley, H., Ingham, E., and Foster, S.J. (2001a). PerR controls oxidative stress resistance and iron storage proteins and is required for virulence in Staphy-lococcus aureus. Infect. Immun. 69, 3744-3754.
13. Horsburgh, M.J., Ingham, E., and Foster, S.J. (2001b). In Staphy-lococcus aureus, fur is an interactive regulator with PerR, contributes to virulence, and is necessary for oxidative stress resistance through positive regulation of catalase and iron home-ostasis. J. Bacteriol. 183, 468-475.
14. Inglesby, T.V., O'Toole, T., Henderson, D.A., Bartlett, J.G., Ascher, M.S., Eitzen, E., Friedlander, A.M., Gerberding, J., Hauer, J., Hughes, J., et al. (2002). Anthrax as a biological weapon, 2002: updated recommendations for management. J. Am. Med. Assoc. 287, 2236-2252.
15. Karlsson, M., Sahlin, M., and Sjöberg, B.-M. (1992). Escherichia coli ribonucleotide reductase. Radical susceptibility to hydroxyurea is dependent on the regulatory state of the enzyme. J. Biol. Chem. 267, 12622-12626.
16. Ko, M., Choi, H., and Park, C. (2002). Group I self-splicing intron in the recA gene of Bacillus anthracis. J. Bacteriol. 184, 3917-3922.
17. Larsen, I.K., Sjöberg, B.-M., and Thelander, L. (1982). Characterization of the active site of ribonucleotide reductase of Escherichia coli, bacteriophage T4 and mammalian cells by inhibition studies with hydroxyurea analogues. Eur. J. Biochem. 125, 75-81.
18. Lundin, D., Torrents, E., Poole, A.M., and Sjöberg, B.M. (2009). RNRdb, a curated database of the universal enzyme family ribo-nucleotide reductase, reveals a high level of misannotation in sequences deposited to GenBank. BMC Genomics 10, 589.
19. Mock, M. and Fouet, A. (2001). Anthrax. Annu. Rev. Microbiol. 55, 647-671.
20. Nord, D., Torrents, E., and Sjöberg, B.-M. (2007). A functional homing endonuclease in the Bacillus anthracis nrdE group I intron. J. Bacteriol. 189, 5293-5301.
21. Nordlund, P. and Reichard, P. (2006). Ribonucleotide reductases. Annu. Rev. Biochem. 75, 681-706.
22. Passalacqua, K.D., Bergman, N.H., Lee, J.Y., Sherman, D.H., and Hanna, P.C. (2007). The global transcriptional responses of Bacillus anthracis Sterne (34F2) and a ΔsodA1 mutant to paraquat reveal metal ion homeostasis imbalances during endogenous superoxide stress. J. Bacteriol. 189, 3996-4013.
23. Raines, K.W., Kang, T.J., Hibbs, S., Cao, G.L., Weaver, J., Tsai, P., Baillie, L., Cross, A.S., and Rosen, G.M. (2006). Importance of nitric oxide synthase in the control of infection by Bacillus anthracis. Infect. Immun. 74, 2268-2276.
24. Roca, I., Torrents, E., Sahlin, M., Gibert, I., and Sjöberg, B.-M. (2008). NrdI essentiality for class Ib ribonucleotide reduction in Streptococcus pyogenes. J. Bacteriol. 190, 4849-4858.
25. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual, 2nd edition (Cold Spring Harbor, New York, USA: Cold Spring Harbor Laboratory Press).
26. Thelander, L., Sjöberg, B.-M., and Eriksson, S. (1978). Ribonucle-oside diphosphate reductase (Escherichia coli). Methods Enzymol. 51, 227-237.
27. Torrents, E., Roca, I., and Gibert, I. (2003). Corynebacterium ammoniagenes class Ib ribonucleotide reductase: transcriptional regulation of an atypical genomic organization in the nrd cluster. Microbiology 149, 1011-1020.
28. Torrents, E., Sahlin, M., Biglino, D., Gräslund, A., and Sjöberg, B.-M. (2005). Efficient growth inhibition of Bacillus anthracis by knocking out the ribonucleotide reductase tyrosyl radical. Proc. Natl. Acad. Sci. USA 102, 17946-17951.
29. Torrents, E., Westman, M., Sahlin, M., and Sjöberg, B.-M. (2006). Ribonucleotide reductase modularity: atypical duplication of the ATP-cone domain in Pseudomonas aeruginosa. J. Biol. Chem. 281, 25287-25296.
30. Torrents, E., Sahlin, M., and Sjöberg, B.-M. (2008). The ribonu-cleotide reductase family - genetics and genomics. In: Ribo-nucleotide Reductases, K.K. Andersson, ed. (New York, USA: Nova Science Publishers), pp. 17-77.
31. Vassinova, N. and Kozyrev, D. (2000). A method for direct cloning of fur-regulated genes: identification of seven new fur-regulated loci in Escherichia coli. Microbiology 146, 3171-3182.
32. Yellaboina, S., Ranjan, S., Chakhaiyar, P., Hasnain, S.E., and Ranjan, A. (2004). Prediction of DtxR regulon: identification of binding sites and operons controlled by Diphtheria toxin repressor in Corynebacterium diphtheriae. BMC Microbiol. 4, 38.