Altered metabolism in the melatonin-related receptor (GPR50) knockout mouse

American Journal of Physiology - Endocrinology and Metabolism

Volumn 294, Issue 1, 2008, Pages

  Ivanova, Elena A ^a   Bechtold, David A ^a   Dupré, Sandrine M ^a   Brennand, John ^b   Barrett, Perry ^c   Luckman, Simon M ^a   Loudon, Andrew S I ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Dorsomedial hypothalamus; Metabolic rate; Obesity; Tanycyte

Indexed keywords

BETA GALACTOSIDASE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 50; MELATONIN RECEPTOR; OXYGEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BASAL METABOLIC RATE; BODY FAT; BODY WEIGHT; BRAIN THIRD VENTRICLE; C57BL 6 MOUSE; CIRCADIAN RHYTHM; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVITY; EPENDYMA CELL; GENE EXPRESSION; GENE INSERTION; GENE SEQUENCE; HYPOTHALAMUS; IN SITU HYBRIDIZATION; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; OXYGEN CONSUMPTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN METABOLISM; RESPIRATORY QUOTIENT; STATISTICAL SIGNIFICANCE; THALAMUS DORSOMEDIAL NUCLEUS; WEIGHT GAIN;

ANIMALS; CIRCADIAN RHYTHM; DORSOMEDIAL HYPOTHALAMIC NUCLEUS; ENERGY METABOLISM; FASTING; MALE; MICE; MICE, KNOCKOUT; MOTOR ACTIVITY; NERVE TISSUE PROTEINS; OBESITY; RECEPTORS, G-PROTEIN-COUPLED; WEIGHT GAIN;

EID: 38349013194     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00199.2007     Document Type: Article

References (26)

1. Barrett P, Ivanova E, Graham ES, Ross AW, Wilson D, Ple H, Mercer JG, Ebling FJ, Schuhler S, Dupre SM, Loudon A, Morgan PJ. Photoperiodic regulation of cellular retinoic acid-binding protein 1, GPR50 and nestin in tanycytes of the third ventricle ependymal layer of the Siberian hamster. J Endocrinol 191: 687-698, 2006.
2. Bellinger LL, Bernardis LL, Brooks S. The effect of dorsomedial hypothalamic nuclei lesions on body weight regulation. Neuroscience 4: 659-665, 1979.
3. Berger UV, Hediger MA. Differential distribution of the glutamate transporters GLT-1 and GLAST in tanycytes of the third ventricle. J Comp Neurol 433: 101-114, 2001.
4. Bernardis LL, Bellinger LL. Brown (BAT) and white (WAT) adipose tissue in high-fat junk food (HFJF) and chow-fed rats with dorsomedial hypothalamic lesions (DMNL rats). Behav Brain Res 43: 191-195, 1991.
5. Bhattacharyya S, Luan J, Challis B, Keogh J, Montague C, Brennand J, Morten J, Lowenbeim S, Jenkins S, Farooqi IS, Wareham NJ, O'Rahilly S. Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels. J Lipid Res 47: 761-766, 2006.
6. Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 23: 38-89, 2002.
7. Cameron-Smith D, Burke LM, Angus DJ, Tunstall RJ, Cox GR, Bonen A, Hawley JA, Hargreaves M. A short-term, high-fat diet upregulates lipid metabolism and gene expression in human skeletal muscle. Am J Clin Nutr 77: 313-318, 2003.
8. Carlson MG, Snead WL, Campbell PJ. Fuel and energy metabolism in fasting humans. Am J Clin Nutr 60: 29-36, 1994.
9. Conway S, Canning SJ, Barrett P, Guardiola-Lemaitre B, Delagrange P, Morgan PJ. The roles of valine 208 and histidine 211 in ligand binding and receptor function of the ovine Mel1a beta melatonin receptor. Biochem Biophys Res Commun 239: 418-423, 1997.
10. Diano S, Naftolin F, Goglia F, Horvath TL. Fasting-induced increase in type II iodothyronine deiodinase activity and messenger ribonucleic acid levels is not reversed by thyroxine in the rat hypothalamus. Endocrinology 139: 2879-2884, 1998.
11. Dimicco JA, Zaretsky DV. The dorsomedial hypothalamus: a new player in thermoregulation. Am J Physiol Regul Integr Comp Physiol 292: R47-R63, 2007.
12. Drew JE, Barrett P, Mercer JG, Moar KM, Canet E, Delagrange P, Morgan PJ. Localization of the melatonin-related receptor in the rodent brain and peripheral tissues. J Neuroendocrinol 13: 453-458, 2001.
13. Drew JE, Barrett P, Williams LM, Conway S, Morgan PJ. The ovine melatonin-related receptor: cloning and preliminary distribution and binding studies. J Neuroendocrinol 10: 651-661, 1998.
14. Guadaño-Ferraz A, Obregón MJ, St Germain DL, Bernal J. The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain. Proc Natl Acad Sci USA 94: 10391-10396, 1997.
15. Kameda Y, Arai Y, Nishimaki T. Ultrastructural localization of vimentin immunoreactivity and gene expression in tanycytes and their alterations in hamsters kept under different photoperiods. Cell Tissue Res 314: 251-262, 2003.
16. Lechan RM, Fekete C. The TRH neuron: a hypothalamic integrator of energy metabolism. Prog Brain Res 153: 209-235, 2006.
17. Levoye A, Dam J, Ayoub MA, Guillaume JL, Couturier C, Delagrange P, Jockers R. The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. Embo J 25: 3012-3023, 2006.
18. Mihaly E, Fekete C, Legradi G, Lechan RM. Hypothalamic dorsomedial nucleus neurons innervate thyrotropin-releasing hormone-synthesizing neurons in the paraventricular nucleus. Brain Res 891: 20-31, 2001.
19. Peruzzo B, Pastor FE, Blazquez JL, Schobitz K, Pelaez B, Amat P, Rodriguez EM. A second look at the barriers of the medial basal hypothalamus. Exp Brain Res 132: 10-26, 2000.
20. Reppert SM, Weaver DR, Ebisawa T, Mahle CD, Kolakowski LF Jr. Cloning of a melatonin-related receptor from human pituitary. FEBS Lett 386: 219-224, 1996.
21. Rodriguez EM, Blazquez JL, Pastor FE, Pelaez B, Pena P, Peruzzo B, Amat P. Hypothalamic tanycytes: a key component of brain-endocrine interaction. Int Rev Cytol 247: 89-164, 2005.
22. Schuster C, Gauer F, Guerrero H, Lakhdar-Ghazal N, Pevet P, Masson-Pevet M. Photic regulation of mt1 melatonin receptors in the Siberian hamster pars tuberalis and suprachiasmatic nuclei: involvement of the circadian clock and intergeniculate leaflet. J Neuroendocrinol 12: 207-216, 2000.
23. Song CK, Bartness TJ. CNS sympathetic outflow neurons to white fat that express MEL receptors may mediate seasonal adiposity. Am J Physiol Regul Integr Comp Physiol 281: R666-R672, 2001.
24. Thompson RH, Canteras NS, Swanson LW. Organization of projections from the dorsomedial nucleus of the hypothalamus: a PHA-L study in the rat. J Comp Neurol 376: 143-173, 1996.
25. Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA. The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci USA 100: 4903-4908, 2003.
26. Xin X, Storlien LH, Huang XF. Hypothalamic c-fos-like immunoreactivity in high-fat diet-induced obese and resistant mice. Brain Res Bull 52: 235-242, 2000.