Detection of Hb variants and hemoglobinopathies in Indian population using HPLC: Report of 2600 cases

Indian Journal of Pathology and Microbiology

Volumn 53, Issue 1, 2010, Pages 57-62

  Sachdev, Ritesh ^a   Dam, Arpita R ^a   Tyagi, Gaurav ^a  

^a Clinical Reference Lab   (India)

Author keywords

Hemoglobin variants; Hemoglobinopathies; HPLC; Thalassemia

Indexed keywords

HEMOGLOBIN A2; HEMOGLOBIN D; HEMOGLOBIN E; HEMOGLOBIN F; HEMOGLOBIN J; HEMOGLOBIN S; HEMOGLOBIN VARIANT;

ARTICLE; BETA THALASSEMIA; DIAGNOSTIC ACCURACY; HEMOGLOBINOPATHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INDIA; MAJOR CLINICAL STUDY; MICROCYTOSIS; POPULATION;

ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HEMOGLOBINOPATHIES; HEMOGLOBINS; HUMANS; INDIA; INFANT; INFANT, NEWBORN; MALE; YOUNG ADULT;

EID: 77749333036     PISSN: 03774929     EISSN: 09745130     Source Type: Journal    
DOI: 10.4103/0377-4929.59185     Document Type: Article

References (10)

1. Kutlar F. Diagnostic approach to hemoglobinopathies. Hemoglobin 2007;31:243-50.
2. Tyagi S, Saxena R, Choudhry V P. HPLC - how necessary is it for haemoglobinopathy diagnosis in India? Indian J Pathol Microbiol 2003;46:390-3.
3. Joutovsky A, Hadzi-Nesic J, Nardi MA. HPLC retention time as a diagnostic tool for hemoglobin variants and hemoglobinopathies: A study of 60000 samples in a clinical diagnostic laboratory. Clin Chem 2004;50:1736-47.
4. Bravo-Urquiola M, Arends A, Montilla S, Velásquez D, Garcìa G, Alvarez M, et al. Advantages in the use of high performance chromatography technique for screening hemoglobinopathies in Venezuela. Invest Clin 2004;45:309-15.
5. Sood SK, Madan N, Colah R, Sharma S, Apte S V. Collaborative study on Thalassemia 1993. Report of ICMR task force study. Indian Council of Medical Research.
6. Zeng YT, Huang SZ, Zhou LD, Huang HJ, Jiao CT, Tang ZG, et al. Identification of hemoglobin D Punjab by gene mapping. Hemoglobin 1986;10:87-90.
7. Kishore B, Khare P, Gupta RJ, Bisht S, Majumdar K. Hemoglobin E disease in North Indian population: A report of 11 cases. Hematology 2007;12:343-7.
8. Desai D V, Dhanani H, Kapoor AK, Yeluri S V. HbQ-India in a Sindhi family: An uncommon hemoglobin variant. Lab Hematol 2004;10:212-4.
9. Kar BC, Devi S. Clinical profile of sickle cell disease in Orissa. Indian J Pediatr 1997;64:73-7.
10. Rohe RA, Sharma V, Ranney HM. Hemoglobin D Iran alpha A2 beta 22 2-Glu leads to Gln in association with thalassemia. Blood 1973;42: 455-62.