HbQ-India in a Sindhi Family: An uncommon hemoglobin variant

Laboratory Hematology

Volumn 10, Issue 4, 2004, Pages 212-214

  Desai, Devenkumar V ^a,b   Dhanani, Hiren ^a   Kapoor, Amit K ^a   Yeluri, Sashidhar V ^a  

^a Baroda Medical College   (India)

^b NONE   (India)

Author keywords

Hemoglobin electrophoresis; Hemoglobin Q India; High performance liquid chromatography

Indexed keywords

ADENINE; ASPARTIC ACID; CELLULOSE ACETATE; GUANINE; HEMOGLOBIN A2; HEMOGLOBIN ALPHA CHAIN; HEMOGLOBIN Q; HEMOGLOBIN S; HEMOGLOBIN VARIANT; HISTIDINE; UNCLASSIFIED DRUG;

ADULT; ALKALINITY; ANALYTICAL ERROR; ARTICLE; BLOOD PH; CASE REPORT; CODON; DIAGNOSTIC PROCEDURE; ELECTROPHORETIC MOBILITY; GENE MUTATION; GENETIC VARIABILITY; HETEROZYGOSITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INDIA; MALE; PROTEIN STRUCTURE; SCREENING TEST; SICKLE CELL; SOLUBILITY;

ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIAGNOSIS, DIFFERENTIAL; ELECTROPHORESIS; FAMILY HEALTH; HEMOGLOBINOPATHIES; HEMOGLOBINS, ABNORMAL; HUMANS; MALE; PEDIGREE; VARIATION (GENETICS);

EID: 11244299426     PISSN: 10802924     EISSN: None     Source Type: Journal    
DOI: 10.1532/LH96.04058     Document Type: Article

References (5)

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2. Lie-Injo LE, Dozy AM, Kan YW, Lopes M, Todd D. The alpha-globin gene adjacent to the gene for HbQ-alpha 74 Asp replaced by His is deleted, but not that adjacent to the gene for HbG-alpha 30 Glu replaced by Gln; three-fourths of the alpha-globin genes are deleted in HbQ-alpha-thalassemia. Blood. 1979;54: 1407-1416.
3. Lorkin PA, Charlesworth D, Lehman H, et al. Two haemoglobins Q, alpha-74 (EF3) and alpha-75 (EF4) aspartic acid to histidine. Br J Haematol. 1970;19:117-125.
4. Molchanova TP, Pobedimskaya DD, Huisman THJ. The differences in quantities of alpha 2- and alpha 1-globin gene variants in heterozygotes. Br J Haematol. 1994;88:300-306.
5. Sukumaran PK, Merchant SM, Desai MP, et al. Hemoglobin Q India (alpha 64(E13) aspartic acid to histidine) associated with beta-thalassemia observed in three Sindhi families. J Med Genet. 1972;9:436-442.