Synthetic route optimization of PF-00868554, an HCV polymerase inhibitor in clinical evaluation

Synlett

Volumn , Issue 5, 2010, Pages 796-800

  Johnson, Sarah ^a   Drowns, Matt ^a   Tatlock, John ^a   Linton, Angelica ^a   Gonzalez, Javier ^a   Hoffman, Robert ^a   Jewell, Tanya ^a   Patel, Leena ^a   Blazel, Julie ^a   Tang, Mingnam ^a   Li, Hui ^a  

^a PFIZER INC   (United States)

Author keywords

Borane pyridine; Dihydro pyrone; HCV polymerase inhibitor; Heck reaction; Pyridine synthesis

Indexed keywords

ANTIVIRUS AGENT; LEWIS ACID; PF 00868554; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BROMINATION; CYCLIZATION; DRUG SCREENING; DRUG SYNTHESIS; HYDROGENATION; POLYMERIZATION; SONOGASHIRA REACTION; SUBSTITUTION REACTION; TEMPERATURE;

EID: 77749327681     PISSN: 09365214     EISSN: 14372096     Source Type: Journal    
DOI: 10.1055/s-0029-1219352     Document Type: Article

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