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1
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20244380759
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Clinical responses to undiluted and diluted smallpox vaccine. Frey SE, Couch RB, Tacket CO, Treaner JJ, Wolf M, Newman FK, Atmar RL, Edelman R, Nolan CM, Belshe RB
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Clinical responses to undiluted and diluted smallpox vaccine. Frey SE, Couch RB, Tacket CO, Treaner JJ, Wolf M, Newman FK, Atmar RL, Edelman R, Nolan CM, Belshe RB N ENGL J MED 2002 346 17 1265-1274
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N ENGL J MED
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3
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77749276536
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ViroPharma Inc
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ViroPharma announces agreement with SIGA Technologies for sale of biodefense assets, August 25
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ViroPharma announces agreement with SIGA Technologies for sale of biodefense assets. ViroPharma Inc PRESS RELEASE 2004 August 25
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(2004)
PRESS RELEASE
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4
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77749248336
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ST-246: A potent and specific inhibitor of orthopoxvirus replication. Jordan R, Yang G, Laquerre S, Barone L, Pevear DC, Bailey TR, Rippin S, Collett MS, de Clercq E, Neyts J, Jones KF ef al ANTIVIR RES 2005 65 3 Abs 14
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ST-246: A potent and specific inhibitor of orthopoxvirus replication. Jordan R, Yang G, Laquerre S, Barone L, Pevear DC, Bailey TR, Rippin S, Collett MS, de Clercq E, Neyts J, Jones KF ef al ANTIVIR RES 2005 65 3 Abs 14
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5
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20244365201
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A novel, cell culture-derived smallpox vaccine in vaccinia-naive adults. Artenstein AW, Johnson C, Marbury TC, Morrison D, Blum PS, Kemp T, Nichols R, Balser JP, Currie M, Monath TP VACCINE 2005 23 25 3301-3309
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A novel, cell culture-derived smallpox vaccine in vaccinia-naive adults. Artenstein AW, Johnson C, Marbury TC, Morrison D, Blum PS, Kemp T, Nichols R, Balser JP, Currie M, Monath TP VACCINE 2005 23 25 3301-3309
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7
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77749276533
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Comparison of the pharmacodynamics of cidofovir and ST-246. McSharry JJ, Zager K, Weng Q, Jordan R, Hruby D, Drusano GL ICAAC 2005 45 Washington Abs A-460
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Comparison of the pharmacodynamics of cidofovir and ST-246. McSharry JJ, Zager K, Weng Q, Jordan R, Hruby D, Drusano GL ICAAC 2005 45 Washington Abs A-460
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8
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77749248334
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Activity of ST-246 against vaccinia virus (VACV) and cowpox virus (CPV) in primary human keratinocytes (PHKs) monolayers and organotypic raft cultures. Duraffour S, Snoeck R, van den Oord J, Crance J, Garin D, Jordan R, de Clercq E, Andrei G ICAAC 2006 46 San Francisco Abs V-1480
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Activity of ST-246 against vaccinia virus (VACV) and cowpox virus (CPV) in primary human keratinocytes (PHKs) monolayers and organotypic raft cultures. Duraffour S, Snoeck R, van den Oord J, Crance J, Garin D, Jordan R, de Clercq E, Andrei G ICAAC 2006 46 San Francisco Abs V-1480
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-
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9
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33748946630
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Cidofovir resistance in vaccinia virus is linked to diminished virulence in mice. Andrei G, Gammon DB, Fiten P, de Clercq E, Opdenakker G, Snoeck R, Evans DH
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Cidofovir resistance in vaccinia virus is linked to diminished virulence in mice. Andrei G, Gammon DB, Fiten P, de Clercq E, Opdenakker G, Snoeck R, Evans DH J VIROL 2006 80 19 9391-9401
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J VIROL
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10
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77749276534
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FDA approves orphan drug designation for SIGA's smallpox drug, SIGA-246 the designation is for both treatment and prevention of smallpox. SIGA Technologies Inc PRESS RELEASE 2006 December 20
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FDA approves orphan drug designation for SIGA's smallpox drug, SIGA-246 the designation is for both treatment and prevention of smallpox. SIGA Technologies Inc PRESS RELEASE 2006 December 20
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11
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33846623695
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Quenelle DC, Buller RML, Parker S, Keith KA, Hruby DE, Jordan R, Kern ER
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Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice
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Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice. Quenelle DC, Buller RML, Parker S, Keith KA, Hruby DE, Jordan R, Kern ER ANTIMICROB AGENTS CHEMOTHER 2007 51 2 689-695
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(2007)
ANTIMICROB AGENTS CHEMOTHER
, vol.51
, Issue.2
, pp. 689-695
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12
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77749300654
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The combination of anti-poxvirus compounds ST-246 and TTP-018 are synergistic in vitro Chen Y, Abs 140
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The combination of anti-poxvirus compounds ST-246 and TTP-018 are synergistic in vitro Chen Y, Harver C, Yang G, Hruby D, Andrews R, Jordan R INT CONF ANTIVIRAL RES 2007 74 3 Abs 140
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(2007)
INT CONF ANTIVIRAL RES
, vol.74
, pp. 3
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Harver, C.1
Yang, G.2
Hruby, D.3
Andrews, R.4
Jordan, R.5
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13
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Keith K, Kern E, Sanders S, Conley R, Jordan R, Hruby D, Painter G, Prichard M
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Combinations of CMX-001 and ST-246 synergistically inhibit orthopoxvirus replication in vitro, Abs 127
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Combinations of CMX-001 and ST-246 synergistically inhibit orthopoxvirus replication in vitro. Keith K, Kern E, Sanders S, Conley R, Jordan R, Hruby D, Painter G, Prichard M INT CONF ANTIVIRAL RES 2007 74 3 Abs 127
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(2007)
INT CONF ANTIVIRAL RES
, vol.74
, pp. 3
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14
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77749236449
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Successful treatment in the monkeypox and variola primate models of smallpox by the oral drug ST-246. Huggins J, Goff A, Eric M, Twenhafel N, Chapman J, Tate M, Jordan R, Bolken T, Hruby D
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Abs 20
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Successful treatment in the monkeypox and variola primate models of smallpox by the oral drug ST-246. Huggins J, Goff A, Eric M, Twenhafel N, Chapman J, Tate M, Jordan R, Bolken T, Hruby D ANTIVIRAL RES 2007 74 3 Abs 20
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(2007)
ANTIVIRAL RES
, vol.74
, pp. 3
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15
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77749276521
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Quenelle D, Prichard M, Keith K, Collins D, Jordan R, Hruby D, Painter G, Robertson A, Kern E
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Efficacy of delayed therapy using combinations of ST-246 with CMX-001 against systemic cowpox virus infections in mice, Abs 105
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Efficacy of delayed therapy using combinations of ST-246 with CMX-001 against systemic cowpox virus infections in mice. Quenelle D, Prichard M, Keith K, Collins D, Jordan R, Hruby D, Painter G, Robertson A, Kern E ANTIVIRAL RES 2007 74 3 Abs 105
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(2007)
ANTIVIRAL RES
, vol.74
, pp. 3
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16
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34249742507
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Sbrana E, Jordan R, Hruby DE, Mateo RI, Xiao SY, Siirin M, Newman PC, DaRossa AP, Tesh RB
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Efficacy of the antipoxvirus compound ST-246 for treatment of severe orthopoxvirus infection
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Efficacy of the antipoxvirus compound ST-246 for treatment of severe orthopoxvirus infection. Sbrana E, Jordan R, Hruby DE, Mateo RI, Xiao SY, Siirin M, Newman PC, DaRossa AP, Tesh RB AM J TROP MED HYG 2007 76 4 768-773
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AM J TROP MED HYG
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N-(3,3a,4,4a,5,5a, 6,6a-octahydro-1,3-dioxo-4,6-etheno-cycloprop[f] isoindol-2-(1H)-ylcarboxamides: Identification of novel orthopoxvirus egress inhibitors. Bailey TR, Rippin SR, Opsitnick E, Burns CJ, Pevear DC, Collett MS, Rhodes G, Tohan S, Huggins JW, Baker RO, Kern ER ef all MED CHEM 2007 50 7 1442-1444
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N-(3,3a,4,4a,5,5a, 6,6a-octahydro-1,3-dioxo-4,6-etheno-cycloprop[f] isoindol-2-(1H)-ylcarboxamides: Identification of novel orthopoxvirus egress inhibitors. Bailey TR, Rippin SR, Opsitnick E, Burns CJ, Pevear DC, Collett MS, Rhodes G, Tohan S, Huggins JW, Baker RO, Kern ER ef all MED CHEM 2007 50 7 1442-1444
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18
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Byrd C, Sbrana E, Xiao SY, Siirin M, Tesh R, Hruby D, Jordan R
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Antiviral efficacy of ST-246 in a ground squirrel model of severe monkeypox virus infection, Abs 93
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Antiviral efficacy of ST-246 in a ground squirrel model of severe monkeypox virus infection. Byrd C, Sbrana E, Xiao SY, Siirin M, Tesh R, Hruby D, Jordan R ANTIVIR RES 2006 70 1 Abs 93
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(2006)
ANTIVIR RES
, vol.70
, pp. 1
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19
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Characterization of virus variants resistant to the antiviral effects of ST-246. Yang G, Harver C, Hruby D, Jordan R
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Abs 79
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Characterization of virus variants resistant to the antiviral effects of ST-246. Yang G, Harver C, Hruby D, Jordan R ANTIVIR RES 2006 70 1 Abs 79
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(2006)
ANTIVIR RES
, vol.70
, pp. 1
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20
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77749236442
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Chen Y, Yang G, Honeychurch K, Hruby D, Jordan R
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ST-246 inhibits vaccinia virus IMV wrapping in the intracellular vesicles, Abs 77
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ST-246 inhibits vaccinia virus IMV wrapping in the intracellular vesicles. Chen Y, Yang G, Honeychurch K, Hruby D, Jordan R ANTIVIR RES 2006 70 1 Abs 77
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(2006)
ANTIVIR RES
, vol.70
, pp. 1
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21
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77749276529
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Kern E, Keith K, Jordan R, Hruby D, Quenelle D
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Evaluation of ST-246 in vaccinia or cowpox virus infections of mice, Abs 29
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Evaluation of ST-246 in vaccinia or cowpox virus infections of mice. Kern E, Keith K, Jordan R, Hruby D, Quenelle D ANTIVIR RES 2006 70 1 Abs 29
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(2006)
ANTIVIR RES
, pp. 70-71
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22
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26444587116
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Yang G, Pevear DC, Davies MH, Collett MS, Bailey T, Rippen S, Barone L, Burns C, Rhodes G, Tohan S, Huggins JW ef al
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An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus Challenge
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An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus Challenge. Yang G, Pevear DC, Davies MH, Collett MS, Bailey T, Rippen S, Barone L, Burns C, Rhodes G, Tohan S, Huggins JW ef al J VIROL 2005 79 20 13139-13149
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23
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Smith SK, Olson VA, Karem KL, Hruby DE, Jordan R, Damon IA ICAAC
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ST-246 in vitro efficacy against orthopoxvirus variola and orthopoxvirus monkeypox, September 18 Abs F1-953
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ST-246 in vitro efficacy against orthopoxvirus variola and orthopoxvirus monkeypox. Smith SK, Olson VA, Karem KL, Hruby DE, Jordan R, Damon IA ICAAC 2007 47 September 18 Abs F1-953
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(2007)
, vol.47
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24
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35848968505
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Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses. Quenelle DC, Prichard MN, Keith KA, Hruby DE, Jordan R, Painter GR, Robertson A, Kern ER
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Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses. Quenelle DC, Prichard MN, Keith KA, Hruby DE, Jordan R, Painter GR, Robertson A, Kern ER ANTIMICROB AGENTS CHEMOTHER 2007 51 11 4118-4124
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(2007)
ANTIMICROB AGENTS CHEMOTHER
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25
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cowpox and camelpox viruses in cell monolayers and organotypic raft cultures. Duraffour S, Snoeck R, de Vos R, van den Oord JJ, Crance JM, Garin D, Hruby DE, Jordan R, de Clercq E, Andrei G
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Activity of the anti-orthopoxvirus compound ST-246 against vaccinia
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Activity of the anti-orthopoxvirus compound ST-246 against vaccinia, cowpox and camelpox viruses in cell monolayers and organotypic raft cultures. Duraffour S, Snoeck R, de Vos R, van den Oord JJ, Crance JM, Garin D, Hruby DE, Jordan R, de Clercq E, Andrei G ANTIVIR THER 2007 12 8 1205-1216
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ANTIVIR THER
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, Issue.8
, pp. 1205-1216
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SIGA Technologies Inc
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SIGA files application supporting emergency use approval for ST-246, March 24
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SIGA files application supporting emergency use approval for ST-246. SIGA Technologies Inc PRESS RELEASE 2008 March 24
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(2008)
PRESS RELEASE
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SIGA advances ST-246 smallpox antiviral development in Europe, April 15
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SIGA advances ST-246 smallpox antiviral development in Europe. SIGA Technologies Inc PRESS RELEASE 2008 April 15
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(2008)
PRESS RELEASE
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cowpox and camelpox viruses. Duraffour S, Vigne S, Gracel A, Jordan R, Hruby DE, Crance JE, Garin D, Andrei G, Snoeck D
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Antiviral potency of ST-246 on the production of enveloped orthopoxviruses and characterization of ST-246 resistant vaccinia, Abs 35
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Antiviral potency of ST-246 on the production of enveloped orthopoxviruses and characterization of ST-246 resistant vaccinia, cowpox and camelpox viruses. Duraffour S, Vigne S, Gracel A, Jordan R, Hruby DE, Crance JE, Garin D, Andrei G, Snoeck D ANTIVIRAL RES 2008 78 2 Abs 35
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(2008)
ANTIVIRAL RES
, vol.78
, pp. 2
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29
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77749248328
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Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor. Jordan R, Jones K, Bolken T, Tien D, Strasser J, Shanthakumar TR, Frimm A, Corrado M, Strome P, Hruby D
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Abs 41
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Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor. Jordan R, Jones K, Bolken T, Tien D, Strasser J, Shanthakumar TR, Frimm A, Corrado M, Strome P, Hruby D ANTIVIRAL RES 2008 78 2 Abs 41
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(2008)
ANTIVIRAL RES
, vol.78
, pp. 2
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30
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42949107447
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Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor. Jordan R, Tien D, Bolken TC, Jones KF, Tyavanagimatt SR, Strasser J, Frimm A, Corrado ML, Strome PG, Hruby DE
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Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor. Jordan R, Tien D, Bolken TC, Jones KF, Tyavanagimatt SR, Strasser J, Frimm A, Corrado ML, Strome PG, Hruby DE ANTIMICROB AGENTS CHEMOTHER 2008 52 5 1721-1727
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an attenuated modified vaccinia Ankara virus vaccine for smallpox infection. Jones T
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IMVAMUNE
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IMVAMUNE, an attenuated modified vaccinia Ankara virus vaccine for smallpox infection. Jones T CURR OPIN MOL THER 2008 10 4 407-417
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Nalca A, Hatkin JM, Garza NL, Nichols DK, Norris SW, Hruby DE, Jordan R
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Evaluation of orally delivered ST-246 as postexposure prophylactic and antiviral therapeutic in an aerosolized rabbitpox rabbit model
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Evaluation of orally delivered ST-246 as postexposure prophylactic and antiviral therapeutic in an aerosolized rabbitpox rabbit model. Nalca A, Hatkin JM, Garza NL, Nichols DK, Norris SW, Hruby DE, Jordan R ANTIVIR RES 2008 79 2 121-127
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(2008)
ANTIVIR RES
, vol.79
, Issue.2
, pp. 121-127
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SIGA technologies awarded $55 million by federal government to develop broader applications for its lead drug candidate ST-246, September 03
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SIGA technologies awarded $55 million by federal government to develop broader applications for its lead drug candidate ST-246. SIGA Technologies Inc PRESS RELEASE 2008 September 03
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(2008)
PRESS RELEASE
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In vitro efficacy of ST246 against smallpox and monkeypox. Smith SK, Olson VA, Karem KL, Jordan R, Hruby DE, Damon IK
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In vitro efficacy of ST246 against smallpox and monkeypox. Smith SK, Olson VA, Karem KL, Jordan R, Hruby DE, Damon IK ANTIMICROB AGENTS CHEMOTHER 2009 53 3 1007-1012
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(2009)
ANTIMICROB AGENTS CHEMOTHER
, vol.53
, Issue.3
, pp. 1007-1012
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Combinations of 5-iodo-4′-thio-2′-deoxyuridine and ST-246 or CMXOOl synergistically inhibit orthopoxvirus replication in vitro. Keith K, Sanders S, Tiwari K, Maddry J, Secrist J, Jordan R, Hruby D, Lanier R, Painter G, Kern E, Prichard M
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Abs 58
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Combinations of 5-iodo-4′-thio-2′-deoxyuridine and ST-246 or CMXOOl synergistically inhibit orthopoxvirus replication in vitro. Keith K, Sanders S, Tiwari K, Maddry J, Secrist J, Jordan R, Hruby D, Lanier R, Painter G, Kern E, Prichard M ANTIVIRAL RES 2009 82 2 Abs 58
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(2009)
ANTIVIRAL RES
, vol.82
, pp. 2
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36
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Determination of the minimal effective dose and human dose justification. Jordan R, Goff A, Frimm A, Corrado ML, Hensley LE, Byrd CM, Mucker E, Shamblin J, Bolken TC, Wlazlowski C, Johnson W ef al
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ST-246 antiviral efficacy in a nonhuman primate monkeypox model
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ST-246 antiviral efficacy in a nonhuman primate monkeypox model: Determination of the minimal effective dose and human dose justification. Jordan R, Goff A, Frimm A, Corrado ML, Hensley LE, Byrd CM, Mucker E, Shamblin J, Bolken TC, Wlazlowski C, Johnson W ef al ANTIMICROB AGENTS CHEMOTHER 2009 53 5 1817-1822
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(2009)
ANTIMICROB AGENTS CHEMOTHER
, vol.53
, Issue.5
, pp. 1817-1822
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Post-exposure administration with ST-246 prevents the development of severe rabbitpox disease in NZW rabbits. Babas T, Gong K, Sites D, Nieves-Duran LV, Wright R, Rippeon A, Golightly D, Donnelly G, Rhodes L, Hordan R, Hruby D ef al INT CONF ANTIVIRAL RES 2009 22 May 07 LB-11
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Post-exposure administration with ST-246 prevents the development of severe rabbitpox disease in NZW rabbits. Babas T, Gong K, Sites D, Nieves-Duran LV, Wright R, Rippeon A, Golightly D, Donnelly G, Rhodes L, Hordan R, Hruby D ef al INT CONF ANTIVIRAL RES 2009 22 May 07 LB-11
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Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246. Huggins J, Goff A, Hensley L, Mucker E, Shamblin J, Wlazlowski C, Johnson W, Chapman J, Larsen T, Twenhafel N, Karem K ef al
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Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246. Huggins J, Goff A, Hensley L, Mucker E, Shamblin J, Wlazlowski C, Johnson W, Chapman J, Larsen T, Twenhafel N, Karem K ef al ANTIMICROB AGENTS CHEMOTHER 2009 53 6 2620-2625
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(2009)
ANTIMICROB AGENTS CHEMOTHER
, vol.53
, Issue.6
, pp. 2620-2625
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39
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Characterization of mutations in the F13L gene of orthopoxviruses (OPVs) conferring resistance to ST-246. Duraffour S, Snoeck R, Fiten P, Hruby DE, Jordan R, Opdenakker G, Andrei G ICAAC 2009 49 September 14 Abs V-1759
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Characterization of mutations in the F13L gene of orthopoxviruses (OPVs) conferring resistance to ST-246. Duraffour S, Snoeck R, Fiten P, Hruby DE, Jordan R, Opdenakker G, Andrei G ICAAC 2009 49 September 14 Abs V-1759
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40
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77749276527
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Safety, pharmacokinetics, and human dose justification for ST-246: A novel egress inhibitor being developed for treatment of pathogenic orthopoxvirus infections Jordan R, Tyavanagimatt SR, Amantana A, Chinsangaram L, Bolken TC, Tien D, Jones KF, Frimm A, Corrado ML, Marbury TC, Pickens M ef al ICAAC 2009 49 September 13 Abs A1-593
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Safety, pharmacokinetics, and human dose justification for ST-246: A novel egress inhibitor being developed for treatment of pathogenic orthopoxvirus infections Jordan R, Tyavanagimatt SR, Amantana A, Chinsangaram L, Bolken TC, Tien D, Jones KF, Frimm A, Corrado ML, Marbury TC, Pickens M ef al ICAAC 2009 49 September 13 Abs A1-593
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41
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77749276528
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SIGA Technologies Inc
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SIGA technologies receives a $3 million research grant from the national institutes of health, September 02
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SIGA technologies receives a $3 million research grant from the national institutes of health. SIGA Technologies Inc PRESS RELEASE 2009 September 02
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(2009)
PRESS RELEASE
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ST-246 used to treat complications from exposure to recombinant vaccinia virus, September 15
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ST-246 used to treat complications from exposure to recombinant vaccinia virus. SIGA Technologies Inc PRESS RELEASE 2009 September 15
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(2009)
PRESS RELEASE
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Chen Y, Honeychurch KM, Yang G, Byrd CM, Harver C, Hruby DE, Jordan R
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Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis
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Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis. Chen Y, Honeychurch KM, Yang G, Byrd CM, Harver C, Hruby DE, Jordan R VIROLOGY J 2009 6 44
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(2009)
VIROLOGY J
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Dramatic rescue relieves rare case of smallpox infection. Marris E
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Dramatic rescue relieves rare case of smallpox infection. Marris E NAT MED 2007 13 5 517-517
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Adverse event related to smallpox vaccination. Bristol N DISASTER MED PUBLIC HEALTH PREP 2007 1 1 11-12
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Specific targeting of the F13I protein by ST-246 affects orthopoxvirus production differently. Duroffour S, Vigne S, Vermeire K, Garcel A, Vanstreels E, Daelemans D, Yang G, Jordon R, Hruby DE, Crance JM, Garin D et al ANTIVIR THER 2008 13 8 977-990
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Specific targeting of the F13I protein by ST-246 affects orthopoxvirus production differently. Duroffour S, Vigne S, Vermeire K, Garcel A, Vanstreels E, Daelemans D, Yang G, Jordon R, Hruby DE, Crance JM, Garin D et al ANTIVIR THER 2008 13 8 977-990
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47
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Severe eczema vaccinatum in a household contact of a smallpox vaccinee. Vora S, Damon I, Fulginiti V, Weber SG, Kahana M, Stein SL, Gerber SI, Garcia-Houchins S, Lederman E, Hruby D, Collins L et al CLIN INFECT DIS 2008 46 10 1555-1561
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Severe eczema vaccinatum in a household contact of a smallpox vaccinee. Vora S, Damon I, Fulginiti V, Weber SG, Kahana M, Stein SL, Gerber SI, Garcia-Houchins S, Lederman E, Hruby D, Collins L et al CLIN INFECT DIS 2008 46 10 1555-1561
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