N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f] isoindol-2-(1H)-yl)carboxamides: Identification of novel orthopoxvirus egress inhibitors

Journal of Medicinal Chemistry

Volumn 50, Issue 7, 2007, Pages 1442-1444

  Bailey, Thomas R ^a,e   Rippin, Susan R ^a   Opsitnick, Elizabeth ^a   Burns, Christopher J ^a   Pevear, Daniel C ^a   Collett, Marc S ^a   Rhodes, Gerry ^a   Tohan, Sanjeev ^a   Huggins, John W ^b   Baker, Robert O ^b,f   Kern, Earl R ^c   Keith, Kathy A ^c   Dai, Dongcheng ^d   Yang, Guang ^d   Hruby, Dennis ^d   Jordan, Robert ^d  

^a ViroPharma Incorporated   (United States)

^b UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d SIGA Technologies Incorporated   (United States)

^e CEPHALON INC   (United States)

^f ATCC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; N [3,3A,4,4A,5,5A,6,6A OCTAHYDRO 1,3 DIOXO 4,6 ETHENOCYCLOPROP[F]ISOINDOL 2(1H) YL]CARBOXAMIDE DERIVATIVE; ST 246; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; DISEASE MODEL; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; HIGH THROUGHPUT SCREENING; NONHUMAN; ORTHOPOXVIRUS; RAT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VIRUS INFECTION; VIRUS INHIBITION;

ADMINISTRATION, ORAL; ANIMALS; ANTIVIRAL AGENTS; BENZAMIDES; BIOLOGICAL AVAILABILITY; CELL LINE; CRYSTALLOGRAPHY, X-RAY; HUMANS; INDOLES; MACACA FASCICULARIS; MICE; MOLECULAR STRUCTURE; ORTHOPOXVIRUS; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34147157244     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm061484y     Document Type: Article

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