Role of protein kinase C-δ in isoproterenol-induced amylase release in rat parotid acinar cells

Journal of Medical Investigation

Volumn 56, Issue SUPPL. 1, 2009, Pages 368-370

  Sugiya, Hiroshi ^a   Satoh, Keitaro ^a   Matsuki Fukushima, Miwako ^a   Qi, Bing ^a   Guo, Ming Yu ^a   Fujita Yoshigaki, Junko ^a  

^a NIHON UNIVERSITY   (Japan)

Author keywords

Amylase release; MARCKS; Parotid acinar cells; PKC

Indexed keywords

AMYLASE; BETA ADRENERGIC RECEPTOR; CYCLIC AMP; ISOPRENALINE; MARCKS PROTEIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE C DELTA; ROTTLERIN;

ACINAR CELL; CONFERENCE PAPER; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; NONHUMAN; PAROTID GLAND; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

ACETOPHENONES; ADRENERGIC BETA-AGONISTS; AMYLASES; ANIMALS; BENZOPYRANS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOPROTERENOL; MEMBRANE PROTEINS; PAROTID GLAND; PHOSPHORYLATION; PROTEIN KINASE C-DELTA; RATS; SIGNAL TRANSDUCTION;

RATTUS;

EID: 77749324103     PISSN: 13431420     EISSN: None     Source Type: Journal    
DOI: 10.2152/jmi.56.368     Document Type: Conference Paper

References (20)

1. Quissell DO, Watson E, Dowd FJ : Signal transduction mechanisms involved in salivary gland regulated exocytosis. Crit Rev Oral Biol Med 3 : 83-107, 1992
2. Putney JW Jr, McKinney JS, Aub DL, Leslie BA : Phorbol ester-induced protein secretion in rat parotid gland. Mol Pharmacol 26 : 261-266, 1984
3. Takuma T, Ichida T : Phorbol ester stimulates amylase secretion from rat parotid cells. FEBS Lett 199 : 53-56, 1986
4. McKinney JS, Rubin DP : Enhancement of cyclic AMP modulated salivary amylase secretion by protein kinase C activators. Biochem Pharmacol 37 : 4433-4438, 1988
5. Breitkreutz D, Braiman-Wiksman L, Daum N, Denning MF, Tennenbaum T : Protein kinase C family : on the crossroads of cell signaling in skin and tumor epithelium. J Cancer Res Clin Oncol 133 : 793-808, 2007
6. Steinberg SF : Structural basis of protein kinase C isoform function. Physiol Rev 88 : 1341-1378, 2008
7. Terzian AR, Rubin RP : Translocation of the α-isozyme of protein kinase C during stimulation of rat parotid acinar cells by phorbol ester and carbachol. Arch Oral Biol 38 : 1051-1056, 1993
8. Terzian AR, Zhang X, Rubin RP : Differential modulation of protein kinase C isozymes in rat parotid acinar cells. Biochem Pharmacol 52 : 569-577, 1996
9. Soltoff SP : Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cδ tyrosine phosphorylation. J Biol Chem 276 : 37986-37992, 2001
10. Tapia JA, Jensen RT, García-Marín LJ : Rottlerin inhibits stimulated enzymatic secretion and several intracellular signaling transduction pathways in pancreatic acinar cells by a non-PKC-δ-dependent mechanism. Biochim Biophys Acta 1763 : 25-38, 2006
11. Shirai Y, Saito N : Activation mechanisms of protein kinase C : maturation, catalytic activation, and targeting. J Biochem 132 : 663-668, 2002
12. Stumpo DJ, Graff JM, Albert KA, Greengard P, Blackshear PJ : Molecular cloning, characterization, and expression of a cDNA encoding the "80- to 87-kDa" myristoylated alanine-rich C kinase substrate : a major cellular substrate for portion kinase C. Proc Natl Acad Sci USA 86 : 4012-4016, 1989
13. Agrawal A, Rengarajan S, Adler KB, Ram A, Ghosh B, Fahim M, Dickey BF : Inhibition of mucin secretion with MARCKS-related peptide improves airway obstruction in a mouse model of asthma. J Appl Physiol 102 : 399-405, 2007
14. Singer M, Martin LD, Vargaftig BB, Park J, Gruber AD, Li Y, Adler KB : A MARCKS-related peptide blocks mucus hypersecretion in a mouse model of asthma. Nat Med 10 : 193-196, 2004
15. Li Y, Martin LD, Spizz G, Adler KB : MARCKS protein is a key molecule regulating mucin secretion by human airway epithelial cells in vitro. J Biol Chem 276 : 40982-40990, 2001
16. Rosé SD, Lejen T, Zhang L, Trifaró JM : Chromaffin cell F-actin disassembly and potentiation of catecholamine release in response to protein kinase C activation by phorbol esters is mediated through myristoylated alanine-rich C kinase substrate. J Biol Chem 276 : 36757-36763, 2001
17. Trifaró JM, Rosé SD, Lejen T, Elzagallaai A : Two pathway control chromaffin cell cortical F-actin dynamics during exocytosis. Biochimie 82 : 339-352, 2000
18. 2+ -dependent activation of phospholipase C in insulin-secreting cells. J Biol Chem 281 : 28499-28507, 2006
19. Salli U, Saito N, Stormshak F : Spatiotemporal interactions of myristoylated alanine-rich C kinase substrate (MARCKS) protein with the actin cytoskeleton and exocytosis of oxytocin upon prostaglandin F2α stimulation of bovine luteal cells. Biol Reprod 69 : 2053-2058, 2003
20. Goodall AR, Turner NA, Walker JH, Ball SG, Vaughan PF : Activation of protein kinase C-α and translocation of the myristoylated alaninerich C kinase substrate correlate with phorbol ester-enhanced noradrenaline release from SH-SY5Y human neuroblastoma cells. J Neurochem 68 : 392-401, 1997