Assessing systemic drug exposure in repeated dose toxicity studies in the case of complete and incomplete sampling

Biometrical Journal

Volumn 51, Issue 6, 2009, Pages 1017-1029

  Wolfsegger, Martin J ^a   Jaki, Thomas ^b  

^a BAXTER INNOVATIONS GMBH   (Austria)

^b LANCASTER UNIVERSITY   (United Kingdom)

Author keywords

AUC; Batch design; Repeated dosing; Sparse sampling; Toxicology

Indexed keywords

BLOOD; COMPRESSED SENSING; DRUG DOSAGE; SAMPLING; TOXICITY;

AUC; BATCH DESIGN; BLOOD SAMPLES; BLOOD VOLUMES; INCOMPLETE SAMPLINGS; REPEATED DOSING; SAMPLING DESIGN; SPARSE SAMPLING; TIME POINTS; TOXICOLOGY;

ANIMALS;

ARTICLE; ARTIFACT; CLINICAL TRIAL; DRUG ADMINISTRATION; DRUG TOXICITY; EPIDEMIOLOGY; HUMAN; INCIDENCE; METHODOLOGY; PROPORTIONAL HAZARDS MODEL; RISK ASSESSMENT; RISK FACTOR; SAMPLE SIZE; STATISTICAL ANALYSIS;

ARTIFACTS; BIAS (EPIDEMIOLOGY); CLINICAL TRIALS AS TOPIC; DATA INTERPRETATION, STATISTICAL; DRUG ADMINISTRATION SCHEDULE; DRUG TOXICITY; HUMANS; INCIDENCE; PROPORTIONAL HAZARDS MODELS; RISK ASSESSMENT; RISK FACTORS; SAMPLE SIZE;

EID: 77749323223     PISSN: 03233847     EISSN: 15214036     Source Type: Journal    
DOI: 10.1002/bimj.200900151     Document Type: Article

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