MUC18/MCAM (CD146), An Activation Antigen of Human T Lymphocytes

Journal of Immunology

Volumn 158, Issue 5, 1997, Pages 2107-2115

  Pickl, Winfried F ^a   Majdic, Otto ^a   Fischer, Gottfried F ^a   Petzelbauer, Peter ^a   Faé, Ingrid ^a   Waclavicek, Martina ^a   Stöckl, Johannes ^a   Scheinecker, Clemens ^a   Vidicki, Tina ^a   Aschauer, H ^b   Johnson, Judith P ^c   Knapp, Walter ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD146 ANTIGEN; CELL ADHESION MOLECULE; EPITOPE; LEUKOCYTE ANTIGEN; MCAM PROTEIN, HUMAN; MEMBRANE PROTEIN; MESSENGER RNA; MONOCLONAL ANTIBODY; NERVE CELL ADHESION MOLECULE; T LYMPHOCYTE ANTIGEN;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; GENETIC TRANSCRIPTION; GENETICS; HUMAN; IMMUNOLOGY; KINETICS; LYMPHOCYTE ACTIVATION; MELANOMA; METABOLISM; MOLECULAR GENETICS; MOLECULAR WEIGHT; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; T LYMPHOCYTE;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD146; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; ARTHRITIS, RHEUMATOID; CELL ADHESION MOLECULES; EPITOPES; HUMANS; KINETICS; LYMPHOCYTE ACTIVATION; MELANOMA; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; NEURAL CELL ADHESION MOLECULES; RNA, MESSENGER; SYNOVIAL FLUID; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0031092656     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Lehmann, J. M., B. Holzmann, E. W. Breitbart, P. Schmiegelow, G. Riethmüller, and J. P. Johnson. 1987. Discrimination between benign and malignant cells of melanocytic lineage by two novel antigens, a glycoprotein with a molecular weight of 113,000 and a protein with a molecular weight of 76,000. Cancer Res. 47:841.
2. Lehmann, J. M., G. Riethmüller, and J. P. Johnson. 1989. MUC18, a marker of tumor progression in human melanoma, shows sequence similarity of the neural cell adhesion molecules of the immunoglobulin superfamily. Proc. Natl. Acad. Sci. USA 86:9891.
3. Bardin, N., V. Francès, G. Lesaule, N. Horschowski, F. George, and J. Sampol. 1996. Identification of the S-Endo 1 endothelial-associated antigen. Biochem. Biophys. Res. Commun. 218:210.
4. Shih, L. M., D. E. Elder, D. Speicher, J. P. Johnson, and M. Herlyn. 1994. Isolation and functional characterization of the A32 melanoma-associated antigen. Cancer Res. 54:2514.
5. Sers, C., K. Kirsch, U. Rothbächer, G. Riethmüller, and J. P. Johnson. 1993. Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains. Proc. Natl. Acad. Sci. USA 90:8514.
6. Burns, F. R., S. Von Kannen, L. Guy, J. A. Raper, J. Kamholz, and S. Chang. 1991. DM-GRASP, a novel immunoglobulin superfamily axonal surface protein that supports neurite extension. Neuron 7:209.
7. Pourquié, O., C. Corbel, J.-P. Le Caer, J. Rossier, and N. M. Le Douarin. 1992. BEN, a surface glycoprotein of the immunoglobulin superfamily, is expressed in a variety of developing systems. Proc. Natl. Acad. Sci. USA 89:5261.
8. Tanaka, H., T. Matsui, A. Agata, M. Tomura, I. Kubota, D. K. McFarland, B. Kohr, A. Lee, H. S. Phillips, and D. L. Shellon. 1991. Molecular cloning of a novel adhesion molecule, SC1. Neuron 7:933.
9. Taira, E., N. Takaha, H. Taniura, C. H. Kim, and N. Miki. 1994. Molecular cloning and functional expression of gicerin, a novel cell adhesion molecule that binds to neurite outgrowth factor. Neuron 12:861.
10. Laessing, U., S. Giordano, B. Stecher, F. Lottspeich, and C. A. Stuermer. 1994. Molecular characterization of fish neurolin: a growth-associated cell surface protein and member of the immunoglobulin superfamily in the fish retinotectal system with similarities to chicken protein DM-GRASP/SC-1/BEN. Differentiation 56:21.
11. Paschke, K. A., F. Lottspeich, and C. A. Stuermer. 1992. Neurolin, a cell surface glycoprolein on growing retinal axons in the goldfish visual system, is reexpressed during retinal axonal regeneration. J. Cell Biol. 117:863.
12. Parsons, S. F., G. Mallinson, C. H. Holmes, J. M. Moulihan, K. L. Simpson, W. J. Mawby, N. K. Spurr, D. Warne, A. N. Barclay, and D. J. Anstee. 1995. The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human tissues and is developmentally regulated in human liver. Proc. Natl. Acad. Sci. USA 92:5496.
13. Campbell, I. G., W. D. Foulkes, G. Senger, J. Trowsdale, P. Garin-Chesa, and W. J. Rettig. 1994. Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily. Cancer Res. 54:5761.
14. Johnson, J. P., and M. M. Rummel. 1996. MUC18 is a heterophilic cell adhesion molecule potentially involved in the dissemination of melanoma cells. In Immunology of Human Melanoma. M. Maio, ed. IOS Press, Amsterdam, p. 31.
15. Luca, M., B. Hunt, C. D. Bucana, J. P. Johnson, I. J. Fidler, and M. Bar-Eli. 1993. Direct correlation between MUC18 expression and metastatic potential of human melanoma cells. Melanoma Res. 3:35.
16. Dustin, M. L., and T. A. Springer. 1989. T cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature 341:619.
17. van Kooyk, Y., P. van de Wicl van Kememade, P. Weder, T. W. Kuijpers, and C. Figdor. 1989. Enhancement of LFA-1 mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes. Nature 342:811.
18. Meuer, S. C., R. E. Hussey, M. Fabbi, D. Fox, O. Acuto, K. A. Fitzgerald, J. C. Hodgdon, J. P. Protentis, S. F. Schlossman, and E. L. Reinherz. 1984. An alternative pathway of T cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein. Cell 36:897.
19. Hahn, W. C., V. Rosenstein, V. Calvo, S. J. Burakoff, and B. E. Bierer 1992. A distinct cytoplasmic domain of CD2 regulates ligand avidity and T cell responsiveness to antigen. Proc. Natl. Acad Sci. USA 89:7179.
20. Hahn, W. C., and B. E. Bierer. 1993. Separable portions of the CD2 cytoplasmic domain involved in signaling and ligand avidity regulation. J. Exp. Med. 178: 1831.
21. Teixido, J., C. M. Parker, P. D. Kassner, and M. E. Hemler. 1992. Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage. J. Biol. Chem. 267:1786.
22. Blue, M. L., G. Davis, P. Conrad, and K. Kelley. 1993. Specific cleavage of the alpha 4 integrin associated with activation of peripheral T lymphocytes. Immunology 78:80.
23. Nykjaer, A., B. Moller, R. F. Todd III, T. Christensen, P. A. Andreasen, J. Gliemann, and C. M. Petersen. 1994. Urokinase receptor: an activation antigen in human T lymphocytes. J. Immunol. 152:505.
24. Kasinrerk, W., E. Fiebiger, I. Stefanova, T. Baumruker, W. Knapp, and H. Stockinger. 1992. Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule. J. Immunol. 149:847.
25. Bonnard, G., K. Yaska, and D. Jacobson. 1979. Ligand-activated T cell growth factor-induced proliferation: absorption of T cell growth factor by activated T cells. J. Immunol. 123:2704.
26. Robb, R., A. Munck, and K. Smith. 1981. T cell growth factor receptors: quantitation, specificity, and biological relevance. J. Exp. Med. 154:1455.
27. Uchiyama, T., S. Broder, and T. Waldman. 1981. A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. J. Immunol. 126:1393.
28. Hollenbaug, H., L. S. Grosmaire, C. D. Kullas, N. J. Chalupny, S. Braesch-Andersen, R. J. Noelle, R. I. Stamenkovic, J. A. Ledbetter, and A. Aruffo. 1992. The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulating activity. EMBO J. 11:4313.
29. Noelle, R. J., M. Roy, D. M. Shepherd, I. Stamenkovic, J. A. Ledbetter, and A. Aruffo. 1992. A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc. Natl. Acad. Sci. USA 89:6550.
30. Klas, C., K. M. Debatin, R. R. Jonker, and P. H. Krammer. 1993. Activation interferes with the APO-1 pathway in mature human T cells. Int. Immunol. 5:625.
31. Takahashi, T., M. Tanaka, J. Inazawa, T. Abe, T. Suda, and S. Nagata. 1994. Human Fas ligand: gene structure, chromosomal location and species specificity. Int. Immunol. 6:1567.
32. Suda, T., T. Okazaki, Y. Naito, T. Yokota, N. Arai, S. Ozaki, K. Nakao, and S. Nagata. 1995. Expression of the Fas ligand in cells of T cell lineage. J. Immunol. 154:3806.
33. Johnson, J. P. 1995. The melanoma-associated glycoprotein MUC18: a putative endothelial cell adhesion molecule. In Topics in Molecular Medicine. Vol. 1. W. Seiss, R. Lorenz, and P. C. Weber, eds. Raven Press, New York, p. 219.
34. + peripheral blood monocytes. J. Immunol. 157:2001.
35. Majdic, O., J. Stöckl, W. F. Pickl, J. Bohuslav, H. Strobl, C. Scheinecker, H. Stockinger, and W. Knapp. 1994. Signaling and induction of enhanced cytoadhesiveness via the hematopoietic progenitor cell surface molecule CD34. Blood 83:1226.
36. 2-microglobulin free HLA class I α-chains: qualitative and quantitative characterization. J. Immunol. 151:2613.
37. Leammli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 277:680.
38. Towbin, H., T. Staehlin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and applications. Proc. Natl. Acad. Sci. USA 76:4350.
39. Petzelbauer, P., J. R. Bender, I. Wilson, and J. S. Dober. 1993. Heterogeneity of dermal microvascular endothelial cell antigen expression and cytokine responsiveness in situ and in cell culture. J. Immunol. 151:5062.
40. Gröger, M., G. Sarmay, E. Fiebiger, K. Wolff, and P. Petzelbauer. 1996. Dermal microvascular endothelial cells express CD32 receptors in vivo and in vitro. J. Immunol. 156:1549.
41. Hoon, D. S. B., Y. Wang, P. S. Dale, A. J. Conrad, P. Schmid, D. Garrison, C. Kuo, L. J. Foshag, A. J. Nizze, and D. L. Morton. 1995. Detection of occult melanoma cells in blood with a multiple-marker polymerase chain reaction assay. J. Clin. Oncol. 13:2109.
42. 2-microglobulin. J. Exp. Med. 171:1431.
43. Shaw, S., and W. Gilks. 1995. Cross-lineage (blind panel) antigens. In Leucocyte Typing V. Vol. 1. S. F. Schlossman, L. Boumsell, W. Gilks, J. M. Harlan, T. Kishimoto, C. Morimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, T. F. Tedder, and R. F. Todd, eds. Oxford University Press, Oxford, p. 1.
44. Sers, C., G. Riethmüller, and J. P. Johnson. 1994. MUC18, a melanoma-progression associated molecule, and its potential role in tumor vascularization and hematogenous spread. Cancer Res. 54:5689.
45. Takahashi, H., K. Söderström, E. Nilsson, R. Kiessling, and M. Patarroyo. 1992. Integrins and other adhesion molecules on lymphocytes from synovial fluid and peripheral blood of rheumatoid arthritis patients. Eur. J. Immunol. 22:2879.
46. Hemler, M. E., D. Glass, J. S. Coblyn, and J. G. Jacobson. 1986. Very late activation antigens on rheumatoid synovial fluid T lymphocytes: association with stages of T cell activation. J. Clin. Invest. 78:696.
47. + T cells in synovial fluid and tissues of patients with rheumatoid arthritis. Arthritis Rheum. 24:1370.
48. Yokota, A., N. Murata, O. Saiki, M. Shimiziu, T. A. Springer, and T. Kishimoto. 1995. High avidity state of leukocyte function-associated antigen-1 on rheumatoid synovial fluid T lymphocytes. J. Immunol. 155:4118.
49. Poulter, L. W., G. J. Seymour, O. Duke, G. Janossy, and G. Panayi. 1982. Immunohistological analysis of delayed-type hypersensitivity in man. Cell. Immunol. 74:358.
50. Platt, J. L., B. W. Grant, A. A. Eddy, and A. F. Michael. 1983. Immune cell populations in cutaneous delayed-type hypersensitivity. J. Exp. Med. 158:1227.
51. Shih, I.-M., D. E. Elder, M.-Y. Hsu, and M. Herlyn. 1994. Regulation of Mel-CAM/MUC18 expression on melanocytes of different stages of tumor progression by normal keratinocytes. Am. J. Pathol. 145:837.
52. Unutmaz, D., P. Pileri, and S. Abrignani. 1994. Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J. Exp. Med. 180:1159.
53. Corbel, C., H. G. Bluestein, O. Pourquie, P. Vaigot, and N. M. Le Douarin. 1992. An antigen expressed by avian neuronal cells is also expressed by activated T cells. Cell. Immunol. 141:99.
54. Bowen, M. A., D. D. Patel, X. Li, B. Modrell, A. R. Malacko, W. Wang, H. Marquardt, M. Neubauer, J. M. Pesando, U. Francke, B. F. Haynes, and A. Aruffo. 1995. Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. J. Exp. Med. 181:2213.
55. Patel, D. D., S. F. Wee, L. P. Whichard, M. A. Bowen, J. M. Pesando, A. Aruffo, and B. F. Haynes. 1995. Identification and characterization of a 100-kD ligand for CD6 on human thymic epithelial cells. J. Exp. Med. 181:1563.
56. Johnson, J. P., M. M. Rummel, U. Rothbächer, and C. Sers. 1996. MUC18: a cell adhesion molecule with a potential role in tumor growth and tumor dissemination. Curr. Top. Microbiol. Immunol. 213:95.
57. Bazil, V. 1995. Physiological enzymatic cleavage of leukocyte membrane molecules. Immunol. Today 16:135.
58. Rummel, M. M., C. Sers, and J. P. Johnson. 1996. Phorbol ester and cyclic AMP-mediated regulation of the melanoma-associated cell adhesion molecule MUC18/MCAM. Cancer Res. 56:2218.
59. Vassalli, J. D., A. P. Sappino, and D. Belin. 1991. The plasminogen activator/ plasmin system. J. Clin. Invest. 88:1067.
60. Biswas, C., Y. Zhang, R. DeCastro, H. Guo, T. Nakamura, H. Kataoka, and K. Nabeshima. 1995. The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. Cancer Res. 55:434.