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40
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77749233917
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3CN without the manganese reagent only led to recovery of 1a (99%)
-
3CN without the manganese reagent only led to recovery of 1a (99%).
-
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41
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34547763398
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T. V. Duncan, T. Ishizuka, M. Therien, J. Am. Chem. Soc. 2007, 129, 9691.
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44
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77749246319
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-
Over-oxidation took place to produce cyclodocecane-1, 5-dione as the by-product (<5% yield)
-
Over-oxidation took place to produce cyclodocecane-1, 5-dione as the by-product (<5% yield).
-
-
-
-
45
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33845183266
-
-
3). For examples
-
3). For examples, see:a) R. Mello, M. Fiorentino, C. Fusco, R. Curci, J. Am. Chem. Soc. 1989, 111, 6749.
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48
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62049085234
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49
-
-
77749246320
-
-
See the Experimental Section
-
See the Experimental Section.
-
-
-
-
50
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-
77749246313
-
-
As a separate experiment, we found that alcohol 5 was also oxidized to ketone 2a under these conditions in high yield, supporting the intermediacy of 5 via 4 in the reactions of entries 2-4
-
As a separate experiment, we found that alcohol 5 was also oxidized to ketone 2a under these conditions in high yield, supporting the intermediacy of 5 via 4 in the reactions of entries 2-4.
-
-
-
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51
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77749246312
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The oxidation of octyl methyl ether under the standard reaction conditions afforded octanoic acid in 47% NMR yield. This result shows that the present Mn-catalyzed oxidation of primary methyl ethers produces the corresponding carboxylic acids as a product
-
The oxidation of octyl methyl ether under the standard reaction conditions afforded octanoic acid in 47% NMR yield. This result shows that the present Mn-catalyzed oxidation of primary methyl ethers produces the corresponding carboxylic acids as a product.
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