Hyponatraemia: A strong predictor of mortality in adults with congenital heart disease

European Heart Journal

Volumn 31, Issue 5, 2010, Pages 595-601

  Dimopoulos, Konstantinos ^a,b   Diller, Gerhard Paul ^a,b   Petraco, Ricardo ^a   Koltsida, Evdokia ^a   Giannakoulas, Georgios ^a   Tay, Edgar Lik ^a   Best, Nicky ^c   Piepoli, Massimo F ^b   Francis, Darrel P ^d   Poole Wilson, Philip A ^b   Gatzoulis, Michael A ^a,b  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d ST MARY S HOSPITAL   (United Kingdom)

Author keywords

Congenital heart defects; Heart failure; Hyponatraemia; Prognosis; Sodium

Indexed keywords

DIURETIC AGENT;

ADULT; AGE; ARTICLE; CONGENITAL HEART DISEASE; CREATININE BLOOD LEVEL; CYANOSIS; EISENMENGER COMPLEX; FEMALE; FONTAN PROCEDURE; GREAT VESSELS TRANSPOSITION; HUMAN; HYPONATREMIA; MAJOR CLINICAL STUDY; MALE; MORTALITY; MUSTARD OPERATION; PREVALENCE; PRIORITY JOURNAL; SODIUM BLOOD LEVEL;

ADULT; FEMALE; HEART DEFECTS, CONGENITAL; HUMANS; HYPONATREMIA; MALE; PREVALENCE; PROGNOSIS; RISK FACTORS; SURVIVAL ANALYSIS;

EID: 77749292078     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehp495     Document Type: Article

References (40)

1. Upadhyay A, Jaber BL, Madias NE. Incidence and prevalence of hyponatremia. Am J Med 2006;119:S30-S35.
2. Adrogue HJ, Madias NE. Hyponatremia. N Engl J Med 2000;342:1581-1589.
3. Anand IS, Ferrari R, Kalra GS, Wahi PL, Poole-Wilson PA, Harris PC. Edema of cardiac origin. Studies of body water and sodium, renal function, hemodynamic indexes, and plasma hormones in untreated congestive cardiac failure. Circulation 1989;80:299-305.
4. Aaronson KD, Schwartz JS, Chen T-M, Wong K-L, Goin JE, Mancini DM. Development and prospective validation of a clinical index to predict survival in ambulatory patients referred for cardiac transplant evaluation. Circulation 1997;95: 2660-2667.
5. Mehra MR, Kobashigawa J, Starling R, Russell S, Uber PA, Parameshwar J, Mohacsi P, Augustine S, Aaronson K, Barr M. Listing criteria for heart transplantation: international society for heart and lung transplantation guidelines for the care of cardiac transplant candidates-2006. J Heart Lung Transp 2006;25: 1024-1042.
6. Parameshwar J, Keegan J, Sparrow J, Sutton GC, Poole-Wilson PA. Predictors of prognosis in severe chronic heart failure. Am Heart J 1992;123:421-426.
7. Gheorghiade M, Abraham WT, Albert NM, Gattis Stough W, Greenberg BH, O'Connor CM, She L, Yancy CW, Young J, Fonarow GC, on behalf of the O-HFIaC. Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registry. Eur Heart J 2007;28:980-988.
8. Ohuchi H, Takasugi H, Ohashi H, Yamada O, Watanabe K, Yagihara T, Echigo S. Abnormalities of neurohormonal and cardiac autonomic nervous activities relate poorly to functional status in Fontan patients. Circulation 2004;110:2601-2608.
9. Davos CH, Davlouros PA, Wensel R, Francis D, Davies LC, Kilner PJ, Coats AJS, Piepoli M, Gatzoulis M.A. Global impairment of cardiac autonomic nervous activity late after repair of tetralogy of Fallot. Circulation 2002;106:I-69-I-75.
10. Davos CH, Francis DP, Leenarts MFE, Yap S-C, Li W, Davlouros PA, Wensel R, Coats AJS, Piepoli M, Sreeram N, Gatzoulis MA. Global impairment of cardiac autonomic nervous activity late after the Fontan operation. Circulation 2003; 108:II-180-II-185.
11. Bolger AP, Sharma R, Li W, Leenarts M, Kalra PR, Kemp M, Coats AJS, Anker SD, Gatzoulis MA. Neurohormonal activation and the chronic heart failure syndrome in adults with congenital heart disease. Circulation 2002;106:92-99.
12. Dimopoulos K, Okonko DO, Diller G-P, Broberg CS, Salukhe TV, Babu-Narayan SV, Li W, Uebing A, Bayne S, Wensel R, Piepoli MF, Poole-Wilson PA, Francis DP, Gatzoulis MA. Abnormal ventilatory response to exercise in adults with congenital heart disease relates to cyanosis and predicts survival. Circulation 2006;113:2796-2802. (Pubitemid 44305291)
13. Ho D, Imai K, King G, Stuart E. MatchIt: nonparametric preprocessing for parametric causal inference. http://gking.harvard.edu/matchit/ (21 December 2007).
14. Schoefeld D. Chi-squared goodness-of-fit tests for the proportional hazards regression model. Biometrika 1980;67:145-153.
15. Binanay C, Califf R, Hasselblad V, O'Connor C, Shah M, Sopko G, Stevenson L, Francis G, Leier C, Miller L. Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: The ESCAPE trial. JAMA 2005;294: 1625-1633.
16. Ohuchi H, Takasugi H, Ohashi H, Okada Y, Yamada O, Ono Y, Yagihara T, Echigo S. Stratification of pediatric heart failure on the basis of neurohormonal and cardiac autonomic nervous activities in patients with congenital heart disease. Circulation 2003;108:2368-2376.
17. Diller G-P, Dimopoulos K, Okonko D, Li W, Babu-Narayan SV, Broberg CS, Johansson B, Bouzas B, Mullen MJ, Poole-Wilson PA, Francis DP, Gatzoulis MA. Exercise intolerance in adult congenital heart disease: comparative severity, correlates, and prognostic implication. Circulation 2005;112:828-835.
18. Gatzoulis MA, Freeman MA, Siu SC, Webb GD, Harris L. Atrial arrhythmia after surgical closure of atrial septal defects in adults. N Engl J Med 1999;340:839-846.
19. Lilly LS, Dzau VJ, Williams GH, Rydstedt L, Hollenberg NK. Hyponatremia in congestive heart failure: implications for neurohumoral activation and responses to orthostasis. J Clin Endocrinol Metab 1984;59:924-930.
20. LeJemtel TH, Serrano C. Vasopressin dysregulation: hyponatremia, fluid retention and congestive heart failure. Int J Cardiol 2007;120:1-9.
21. Schrier RW, Abraham WT. Hormones and hemodynamics in heart failure. N Engl J Med 1999;341:577-585.
22. Ellison DH, Berl T. The syndrome of inappropriate antidiuresis. N Engl J Med 2007; 356:2064-2072.
23. De Luca L, Orlandi C, Udelson JE, Fedele F, Gheorghiade M. Overview of vaso-pressin receptor antagonists in heart failure resulting in hospitalization. Am J Cardiol 2005;96:24-33.
24. Dzau VJ, Packer M, Lilly LS, Swartz SL, Hollenberg NK, Williams GH. Prostaglan-dins in severe congestive heart failure. Relation to activation of the renin-angiotensin system and hyponatremia. N Engl J Med 1984;310:347-352.
25. Sanghi P, Uretsky BF, Schwarz ER. Vasopressin antagonism: a future treatment option in heart failure. Eur Heart J 2005;26:538-543.
26. Francis GS, Benedict C, Johnstone DE, Kirlin PC, Nicklas J, Liang CS, Kubo SH, Rudin-Toretsky E, Yusuf S. Comparison of neuroendocrine activation in patients with left ventricular dysfunction with and without congestive heart failure. A sub-study of the Studies of Left Ventricular Dysfunction (SOLVD). Circulation 1990;82: 1724-1729.
27. Share L. Role of vasopressin in cardiovascular regulation. Physiol Rev 1988;68: 1248-1284.
28. Lee CR, Watkins ML, Patterson JH, Gattis W, O'Connor CM, Gheorghiade M, Adams KF. Vasopressin: a new target for the treatment of heart failure. Am Heart J 2003;146:9-18.
29. Dimopoulos K, Diller G-P, Piepoli MF, Gatzoulis MA. Exercise intolerance in adults with congenital heart disease. Cardiol Clin 2006;24:641-660.
30. Lee WH, Packer M. Prognostic importance of serum sodium concentration and its modification by converting-enzyme inhibition in patients with severe chronic heart-failure. Circulation 1986;73:257-267.
31. Lee DS, Austin PC, Rouleau JL, Liu PP, Naimark D, Tu JV. Predicting mortality among patients hospitalized for heart failure: derivation and validation of a clinical model. JAMA 2003;290:2581-2587.
32. Klein L, O'Connor CM, Leimberger JD, Gattis-Stough W, Pina IL, Felker GM, Adams KF Jr, Califf RM, Gheorghiade M, for the O-CHFI. Lower serum sodium is associated with increased short-term mortality in hospitalized patients with worsening heart failure: results from the outcomes of a prospective trial of intravenous milrinone for exacerbations of chronic heart failure (OPTIME-CHF) study. Circulation 2005;111:2454-2460.
33. Levy WC, Mozaffarian D, Linker DT, Sutradhar SC, Anker SD, Cropp AB, Anand I, Maggioni A, Burton P, Sullivan MD, Pitt B, Poole-Wilson PA, Mann DL, Packer M. The Seattle heart failure model: prediction of survival in heart failure. Circulation 2006;113:1424-1433.
34. Goldberg A, Hammerman H, Petcherski S, Nassar M, Zdorovyak A, Yalonetsky S, Kapeliovich M, Agmon Y, Beyar R, Markiewicz W, Aronson D. Hyponatremia and long-term mortality in survivors of acute ST-elevation myocardial infarction. Arch Intern Med 2006;166:781-786.
35. Benedict CR, Shelton B, Johnstone DE, Francis G, Greenberg B, Konstam M, Probstfield JL, Yusuf S. Prognostic significance of plasma norepinephrine in patients with asymptomatic left ventricular dysfunction. Circulation 1996;94: 690-697.
36. Hillege HL, Girbes ARJ, de Kam PJ, Boomsma F, de Zeeuw D, Charlesworth A, Hampton JR, van Veldhuisen DJ. Renal function, neurohormonal activation, and survival in patients with chronic heart failure. Circulation 2000;102:203-210.
37. Valle R, Aspromonte N, Feola M, Milli M, Canali C, Giovinazzo P, Carbonieri E, Ceci V, Cerisano S, Barro S, Milani L. B-type natriuretic peptide can predict the medium-term risk in patients with acute heart failure and preserved systolic function. J Card Fail 2005;11:498-503.
38. Berger R, Huelsmann M, Strecker K, Moertl D, Moser P, Bojic A, Pacher R. Neurohormonal risk stratification for sudden death and death owing to progressive heart failure in chronic heart failure. Eur J Clin Invest 2005;35:24-31.
39. Rouleau JL, Packer M, Moye L, de Champlain J, Bichet D, Klein M, Rouleau JR, Sussex B, Arnold JM, Sestier F. Prognostic value of neurohumoral activation in patients with an acute myocardial infarction: effect of captopril. J Am Coll Cardiol 1994;24:583-591.
40. Engelfriet P, Boersma E, Oechslin E, Tijssen J, Gatzoulis MA, Thilen U, Kaemmerer H, Moons P, Meijboom F, Popelova J, Laforest V, Hirsch R, Daliento L, Thaulow E, Mulder B. The spectrum of adult congenital heart disease in Europe: morbidity and mortality in a 5 year follow-up period. The Euro Heart Survey on adult congenital heart disease. Eur Heart J 2005;26: 2325-2333.