Hyperpolarization-activated cation currents in human epileptogenic neocortex

Epilepsia

Volumn 51, Issue 3, 2010, Pages 404-414

  Wierschke, Stephan ^a,b   Lehmann, Thomas Nicolas ^a   Dehnicke, Christoph ^c   Horn, Peter ^a   Nitsch, Robert ^a   Deisz, Rudolf A ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c MARTIN LUTHER KRANKENHAUS   (Germany)

Author keywords

Epilepsy; HCN channels; Patch clamp; Pharmacoresistance; Temporal lobe

Indexed keywords

4 (N ETHYL N PHENYLAMINO) 1,2 DIMETHYL 6 (METHYLAMINO)PYRIMIDINIUM CHLORIDE; BARIUM ION; CATION;

ADULT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; COMPLEX PARTIAL SEIZURE; CONTROLLED STUDY; FEMALE; FRONTAL LOBE EPILEPSY; GRAND MAL SEIZURE; HUMAN; HUMAN CELL; HYPERPOLARIZATION; ION CURRENT; MALE; NEOCORTEX; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; TEMPORAL LOBE EPILEPSY;

ACTION POTENTIALS; ADULT; ANIMALS; CATIONS; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; EPILEPSY; EPILEPSY, FRONTAL LOBE; EPILEPSY, TEMPORAL LOBE; EPILEPSY, TONIC-CLONIC; FEMALE; HUMANS; ION CHANNEL GATING; MALE; NEOCORTEX; NERVE TISSUE PROTEINS; NEURONS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; PYRAMIDAL CELLS; PYRIMIDINES; RATS; RATS, WISTAR;

EID: 77749270482     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2009.02275.x     Document Type: Article

References (33)

1. Aponte Y, Lien CC, Reisinger E, Jonas P. (2006) Hyperpolarization- activated cation channels in fast-spiking interneurons of rat hippocampus. J Physiol 574:229-243.
2. Avoli M, Olivier A. (1989) Electrophysiological Properties and Synaptic Responses in the Deep Layers of the Human Epileptogenic Neocortex in vitro. J Neurophysiol 61:589-606.
3. Bender RA, Soleymani SV, Brewster AL, Nguyen ST, Beck H, Mathern GW, Baram TZ. (2003) Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. J Neurosci 23:6826-6836.
4. Berger T, Larkum ME, Luscher HR. (2001) High Ih channel density in the distal apical dendrite of layer V pyramidal cells increases bidirectional attenuation of EPSPs. J Neurophysiol 85:855-868.
5. Bräuer AU, Savaskan NE, Kole MHP, Plaschke M, Monteggia LM, Nestler EJ, Simburger E, Deisz RA, Ninnemann O, Nitsch R. (2001) Molecular and functional analysis of hyperpolarization-activated pacemaker channels in the hippocampus after entorhinal cortex lesion. FASEB J 15:2689-2701.
6. Chen K, Aradi I, Thon N, Eghbal-Ahmadi M, Baram TZ, Soltesz I. (2001) Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability. Nat Med 7:331-337.
7. leak channels. J Neurosci 25:8776-8787.
8. Deisz RA, Lehmann T-N, Lanksch WR, Meencke H-J, Nitsch R. (1998) Receptor mechanisms involved in hyperexcitability of cortical tissue from epilepsy surgery. J Physiol 513:P35-P36.
9. B receptor-mediated effects in human and rat neocortical neurones in vitro. Neuropharmacology 38:1755-1766.
10. Deisz RA, Lehmann T-N, Dehnicke C, Nitsch R. (2008) Human cortical neurones in tissues from epilepsy surgery have a reduced chloride extrusion. Proc Physiol Soc 11:C4.
11. Foehring RC, Waters RS. (1991) Contributions of low-threshold calcium current and anomalous rectifier (Ih) to slow depolarizations underlying burst firing in human neocortical neurons in vitro. Neurosci Lett 124:17-21.
12. Franz O, Liss B, Neu A, Roeper J. (2000) Single-cell mRNA expression of HCN1 correlates with a fast gating phenotype of hyperpolarization-activated cyclic nucleotide-gated ion channels (Ih) in central neurons. Eur J Neurosci 12:2685-2693.
13. Harris NC, Constanti A. (1995) Mechanism of block by ZD 7288 of the hyperpolarization-activated inward rectifying current in guinea pig substantia nigra neurons in vitro. J Neurophysiol 74:2366-2378.
14. Huggenberger S, Vater M, Deisz RA. (2009) Interlaminar differences of intrinsic properties of pyramidal neurons in the auditory cortex of mice. Cereb Cortex 19:1008-1018.
15. Kole MHP, Strauss U, Lehmann T-N, Lanksch WR, Meencke H-J, Deisz RA. (1999) Hyperpolarization-activated inward currents of human neocortical neurons. Soc Neurosci 25:844.
16. Ludwig A, Budde T, Stieber J, Moosmang S, Wahl C, Holthoff K, Langebartels A, Wotjak C, Munsch T, Zong XG, Feil S, Feil R, Lancel M, Chien KR, Konnerth A, Pape HC, Biel M, Hofmann F. (2003) Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO J 22:216-224.
17. Magee JC. (1998) Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons. J Neurosci 18:7613-7624.
18. McCormick DA, Pape HC. (1990) Properties of a hyperpolarization-activated cation current and its role in rhythmic oscillation in thalamic relay neurons. J Physiol 431:291-318.
19. McCormick DA, Connors BW, Lighthall JW, Prince DA. (1985) Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex. J Neurophysiol 54:782-806.
20. Nichols CG, Lopatin AN. (1997) Inward rectifier potassium channels. Annu Rev Physiol 59:171-191.
21. Pape HC. (1996) Queer current and pacemaker: the hyperpolarization- activated cation current in neurons. Annu Rev Physiol 58:299-327.
22. Paxinos G, Watson C. (2005) The rat brain in stereotaxic coordinates. Elsevier Acad. Press, Amsterdam.
23. Poolos NP, Migliore M, Johnston D. (2002) Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites. Nat Neurosci 5:767-774.
24. Ramos RL, Tam DM, Brumberg JC. (2008) Physiology and morphology of callosal projection neurones in mouse. Neuroscience 153:654-663.
25. Richichi C, Brewster AL, Bender RA, Simeone TA, Zha Q, Yin HZ, Weiss JH, Baram TZ. (2008) Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels. Neurobiol Dis 29:297-305.
26. Sciancalepore M, Constanti A. (1998) Inward-rectifying membrane currents activated by hyperpolarization in immature rat olfactory cortex neurones in vitro. Brain Res 814:133-142.
27. Shah MM, Anderson AE, Leung V, Lin XD, Johnston D. (2004) Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons. Neuron 44:495-508.
28. Stieber J, Stockl G, Herrmann S, Hassfurth B, Hofmann F. (2005) Functional expression of the human HCN3 channel. J Biol Chem 280:34635-34643.
29. h is associated with enhanced excitability and absence epilepsy. Eur J Neurosci 19:3048-3058.
30. h in rat CA1 pyramidal cells. Epilepsia 44:150-156.
31. Tang B, Sander T, Craven KB, Hempelmann A, Escayg A. (2008) Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy. Neurobiol Dis 29:59-70.
32. B receptors in tissues from pharmacoresistant epilepsy patients. Epilepsia 50:1697-1716.
33. Wierschke S, Lehmann T-N, Dehnicke C, Nitsch R, Deisz RA. (2006) Reductions of hyperpolarization-activated inward currents of human neocortical neurones correlate with severity of epilepsy. Proc Physiol Soc 3:C105.