Crystal structure of HIV-1 reverse transcriptase bound to a non-nucleoside inhibitor with a novel mechanism of action

Angewandte Chemie - International Edition

Volumn 49, Issue 10, 2010, Pages 1805-1808

  Freisz, Séverine ^a   Bec, Guillaume ^a   Radi, Marco ^b   Wolff, Philippe ^a   Crespan, Emmanuele ^c   Angeli, Lucilla ^b   Dumas, Philippe ^a   Maga, Giovanni ^c   Botta, Maurizio ^b   Ennifar, Eric ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b UNIVERSITY OF SIENA   (Italy)

^c CNR   (Italy)

Author keywords

Competitive inhibitors; Enzyme models; HIV 1 reverse transcriptase; Molecular modeling; Structure elucidation

Indexed keywords

ACTIVE SITE; ENZYME MODELS; HIV-1 REVERSE TRANSCRIPTASE; MECHANISM OF ACTION; NUCLEOSIDE ANALOGUES; POLYMERASE ACTIVE SITE; X-RAY STRUCTURE;

BINDING ENERGY; BIOMOLECULES; ENZYME INHIBITION; ENZYMES; MOLECULAR MODELING; VIRUSES;

CRYSTAL STRUCTURE;

4 DIMETHYLAMINO 6 VINYLPYRIMIDINE; 4-DIMETHYLAMINO-6-VINYLPYRIMIDINE; 5 METHYL 1 (4 NITROPHENYL) 2 OXO 2,5 DIHYDRO 1H PYRIDO(3,2 B)INDOLE 3 CARBONITRILE; 5-METHYL-1-(4-NITROPHENYL)-2-OXO-2,5-DIHYDRO-1H-PYRIDO(3,2-B)INDOLE-3-CARBONITRILE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; FUSED HETEROCYCLIC RINGS; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; INDOLE DERIVATIVE; NITRILE; PYRIDONE DERIVATIVE; PYRIMIDINE DERIVATIVE; REVERSE TRANSCRIPTASE, HUMAN IMMUNODEFICIENCY VIRUS 1; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; VINYL DERIVATIVE; VRX 329747; VRX 413638; VRX-329747; VRX-413638;

ARTICLE; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; X RAY CRYSTALLOGRAPHY;

ANTI-HIV AGENTS; CRYSTALLOGRAPHY, X-RAY; HETEROCYCLIC COMPOUNDS, 3-RING; HIV PROTEASE INHIBITORS; HIV REVERSE TRANSCRIPTASE; HUMANS; INDOLES; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITRILES; PYRIDONES; PYRIMIDINES; REVERSE TRANSCRIPTASE INHIBITORS; VINYL COMPOUNDS;

EID: 77749264656     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.200905651     Document Type: Article

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