메뉴 건너뛰기




Volumn 23, Issue 2, 2010, Pages 133-142

mTOR inhibitor/proliferation signal inhibitors: Entering or leaving the field?

Author keywords

Calcineurin inhibitors; Everolimus; Kidney transplant; mTOR inhibitors; Proliferation signal inhibitors; Rapamycin; Sirolimus

Indexed keywords

CALCINEURIN INHIBITOR; CLOBETASOL; CYCLOSPORIN A; EVEROLIMUS; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; TACROLIMUS;

EID: 77749237077     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (79)

References (83)
  • 1
    • 0032105481 scopus 로고    scopus 로고
    • (RAPA, rapamycin, sirolimus): Mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression
    • Sehgal SN. Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression. Clin Biochem. 1998;31:335-340.
    • (1998) Clin Biochem , vol.31 , pp. 335-340
    • Rapamune, S.S.N.1
  • 2
    • 0030832514 scopus 로고    scopus 로고
    • SDZ RAD, a new rapamycin derivative: Pharmacological properties in vitro and in vivo
    • Schuler W, Sedrani R, Cottens S, et al. SDZ RAD, a new rapamycin derivative: pharmacological properties in vitro and in vivo. Transplantation. 1997;64:36-42.
    • (1997) Transplantation , vol.64 , pp. 36-42
    • Schuler, W.1    Sedrani, R.2    Cottens, S.3
  • 3
    • 0033610638 scopus 로고    scopus 로고
    • Sirolimus reduces the incidence of acute rejection episodes despite lower cyclosporine doses in Caucasian recipients of mismatched primary renal allografts: A phase II trial. Rapamune Study Group
    • Kahan BD, Julian BA, Pescovitz MD, Vanrenterghem Y, Neylan J. Sirolimus reduces the incidence of acute rejection episodes despite lower cyclosporine doses in Caucasian recipients of mismatched primary renal allografts: a phase II trial. Rapamune Study Group. Transplantation. 1999;68:1526-1532.
    • (1999) Transplantation , vol.68 , pp. 1526-1532
    • Kahan, B.D.1    Julian, B.A.2    Pescovitz, M.D.3    Vanrenterghem, Y.4    Neylan, J.5
  • 4
    • 33746530366 scopus 로고    scopus 로고
    • Efficacy of sirolimus compared with azathioprine of acute allograft rejection: A randomised multicentre study. The Rapamune US Study Group
    • Kahan BD. Efficacy of sirolimus compared with azathioprine of acute allograft rejection: a randomised multicentre study. The Rapamune US Study Group. Lancet. 2000;356:194-202.
    • (2000) Lancet , vol.356 , pp. 194-202
    • Kahan, B.D.1
  • 5
    • 0032736334 scopus 로고    scopus 로고
    • Entry-into-human study with the novel immunosuppressant SDZ RAD in stable renal transplant recipients
    • Neumayer HH, Paradis K, Korn A, et al. Entry-into-human study with the novel immunosuppressant SDZ RAD in stable renal transplant recipients. Br J Clin Pharmacol. 1999;48:694-703.
    • (1999) Br J Clin Pharmacol , vol.48 , pp. 694-703
    • Neumayer, H.H.1    Paradis, K.2    Korn, A.3
  • 6
    • 0035958104 scopus 로고    scopus 로고
    • RAD in de novo renal transplantation: Comparison of three doses on the incidence and severity of acute rejection
    • Kahan BD, Kaplan B, Lorber MI, Winkler M, Cambon N, Boger RS. RAD in de novo renal transplantation: comparison of three doses on the incidence and severity of acute rejection. Transplantation. 2001;71:1400-1406.
    • (2001) Transplantation , vol.71 , pp. 1400-1406
    • Kahan, B.D.1    Kaplan, B.2    Lorber, M.I.3    Winkler, M.4    Cambon, N.5    Boger, R.S.6
  • 7
    • 33846841155 scopus 로고    scopus 로고
    • A link between protein translation and body weight
    • Rui L. A link between protein translation and body weight. J Clin Invest. 2007;117:310-313.
    • (2007) J Clin Invest , vol.117 , pp. 310-313
    • Rui, L.1
  • 8
    • 36248931517 scopus 로고    scopus 로고
    • Nonimmunosuppressive effects of mammalian target of rapamycin inhibitors
    • Cruzado JM. Nonimmunosuppressive effects of mammalian target of rapamycin inhibitors. Transplant Rev (Orlando). 2008;22:73-81.
    • (2008) Transplant Rev (Orlando) , vol.22 , pp. 73-81
    • Cruzado, J.M.1
  • 9
    • 33846841155 scopus 로고    scopus 로고
    • A link between protein translation and body weight
    • Rui L. A link between protein translation and body weight. J Clin Invest. 2007;117:310-313.
    • (2007) J Clin Invest , vol.117 , pp. 310-313
    • Rui, L.1
  • 10
    • 18144399578 scopus 로고    scopus 로고
    • mTOR-targeted therapy of cancer with rapamycin derivatives
    • Vignot S, Faivre S, Aguirre D, Raymond E. mTOR-targeted therapy of cancer with rapamycin derivatives. Ann Oncol. 2005;16:525-537.
    • (2005) Ann Oncol , vol.16 , pp. 525-537
    • Vignot, S.1    Faivre, S.2    Aguirre, D.3    Raymond, E.4
  • 11
    • 17444416737 scopus 로고    scopus 로고
    • Rapamycin and tumor growth: Mechanisms behind its anticancer activity
    • Koehl GE, Schlitt HJ, Geissler EK. Rapamycin and tumor growth: mechanisms behind its anticancer activity. Transplant Rev 2005;19:20-31.
    • (2005) Transplant Rev , vol.19 , pp. 20-31
    • Koehl, G.E.1    Schlitt, H.J.2    Geissler, E.K.3
  • 13
    • 0028876806 scopus 로고
    • Rapamycin-FK-BP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells
    • Marx SO, Jayaraman T, Go LO, Marks AR. Rapamycin-FK-BP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells. Circ Res. 1995;76:412-417.
    • (1995) Circ Res , vol.76 , pp. 412-417
    • Marx, S.O.1    Jayaraman, T.2    Go, L.O.3    Marks, A.R.4
  • 14
    • 19244366021 scopus 로고    scopus 로고
    • Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients
    • Eisen HJ, Tuzcu EM, Dorent R, et al. Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients. N Engl J Med. 2003;349:847-858.
    • (2003) N Engl J Med , vol.349 , pp. 847-858
    • Eisen, H.J.1    Tuzcu, E.M.2    Dorent, R.3
  • 15
    • 20844461132 scopus 로고    scopus 로고
    • Sirolimus in de novo heart transplant recipients reduces acute rejection and prevents coronary artery disease at 2 years: A randomized clinical trial
    • Keogh A, Richardson M, Ruygrok P, et al. Sirolimus in de novo heart transplant recipients reduces acute rejection and prevents coronary artery disease at 2 years: a randomized clinical trial. Circulation. 2004;110:2694-2700.
    • (2004) Circulation , vol.110 , pp. 2694-2700
    • Keogh, A.1    Richardson, M.2    Ruygrok, P.3
  • 16
    • 34249779568 scopus 로고    scopus 로고
    • Global ARC trial. Temsirolimus, interferon alpha, or both for advanced renal-cell carcinoma
    • Hudes G, Carducci M, Tomczak P, et al; Global ARC trial. Temsirolimus, interferon alpha, or both for advanced renal-cell carcinoma. N Engl J Med. 2007;356:2271-2281.
    • (2007) N Engl J Med , vol.356 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 17
    • 0036174289 scopus 로고    scopus 로고
    • Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
    • Guba M, von Breitenbuch P, Steinbauer M, et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nature Med. 2002;8:128-135.
    • (2002) Nature Med , vol.8 , pp. 128-135
    • Guba, M.1    von Breitenbuch, P.2    Steinbauer, M.3
  • 18
    • 2442668989 scopus 로고    scopus 로고
    • Rapamycin protects allografts from rejection while simultaneously attacking tumors in immunosuppressed mice
    • Koehl GE, Andrassy J, Guba M, et al. Rapamycin protects allografts from rejection while simultaneously attacking tumors in immunosuppressed mice. Transplantation. 2004;77:1319-1326.
    • (2004) Transplantation , vol.77 , pp. 1319-1326
    • Koehl, G.E.1    Andrassy, J.2    Guba, M.3
  • 19
    • 21644469886 scopus 로고    scopus 로고
    • Dosing of rapamycin is critical to achieve an optimal antiangiogenic effect against cancer
    • Guba M, Koehl GE, Neppl E, et al. Dosing of rapamycin is critical to achieve an optimal antiangiogenic effect against cancer. Transpl Int. 2005;18:89-94.
    • (2005) Transpl Int , vol.18 , pp. 89-94
    • Guba, M.1    Koehl, G.E.2    Neppl, E.3
  • 20
    • 16344392137 scopus 로고    scopus 로고
    • Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell-growth
    • Schumacher G, Oidtmann M, Rueggeberg A, et al. Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell-growth. World J Gastroenterol. 2005;11:1420-1425.
    • (2005) World J Gastroenterol , vol.11 , pp. 1420-1425
    • Schumacher, G.1    Oidtmann, M.2    Rueggeberg, A.3
  • 21
    • 27644436740 scopus 로고    scopus 로고
    • Maintenance immunosuppression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies
    • Kauffmann HM, Cherikh WS, Cheng Y, Hanto DW, Kahan BD. Maintenance immunosuppression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies. Transplantation. 2005;80:883-889.
    • (2005) Transplantation , vol.80 , pp. 883-889
    • Kauffmann, H.M.1    Cherikh, W.S.2    Cheng, Y.3    Hanto, D.W.4    Kahan, B.D.5
  • 22
    • 26644443399 scopus 로고    scopus 로고
    • Low incidence of malignancy among sirolimus/cyclosporine-treated renal transplant recipients
    • Kahan BD, Yakupoglu YK, Schoenberg L, et al. Low incidence of malignancy among sirolimus/cyclosporine-treated renal transplant recipients. Transplantation. 2005;80:749-758.
    • (2005) Transplantation , vol.80 , pp. 749-758
    • Kahan, B.D.1    Yakupoglu, Y.K.2    Schoenberg, L.3
  • 23
    • 33645458234 scopus 로고    scopus 로고
    • Sirolimus therapy after early cyclosporine withdrawal reduces the risk for cancer in adult renal transplantation
    • Campistol JM, Eris J, Oberbauer R, et al. Sirolimus therapy after early cyclosporine withdrawal reduces the risk for cancer in adult renal transplantation. J Am Soc Nephrol. 2006;17:581-589.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 581-589
    • Campistol, J.M.1    Eris, J.2    Oberbauer, R.3
  • 24
    • 59649126728 scopus 로고    scopus 로고
    • Conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients: 24-month efficacy and safety results from the CONVERT trial
    • Schena FP, Pascoe MD, Alberu J, et al. Conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients: 24-month efficacy and safety results from the CONVERT trial. Transplantation. 2009;87:233-242.
    • (2009) Transplantation , vol.87 , pp. 233-242
    • Schena, F.P.1    Pascoe, M.D.2    Alberu, J.3
  • 25
    • 20144367584 scopus 로고    scopus 로고
    • Sirolimus for Kaposi's sarcoma in renal-transplant recipients
    • Stallone G, Schena A, Infante B, et al. Sirolimus for Kaposi's sarcoma in renal-transplant recipients. N Engl J Med. 2005;352:1317-1323.
    • (2005) N Engl J Med , vol.352 , pp. 1317-1323
    • Stallone, G.1    Schena, A.2    Infante, B.3
  • 26
    • 33746920339 scopus 로고    scopus 로고
    • Sirolimus conversion for patients with posttransplant Kaposi's sarcoma
    • Lebbé C, Euvrard S, Barrou B, et al. Sirolimus conversion for patients with posttransplant Kaposi's sarcoma. Am J Transplant. 2006;6:2164-2168.
    • (2006) Am J Transplant , vol.6 , pp. 2164-2168
    • Lebbé, C.1    Euvrard, S.2    Barrou, B.3
  • 27
    • 33744473322 scopus 로고    scopus 로고
    • Target of rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: A systematic review and meta-analysis of randomized trials
    • Webster AC, Lee VWS, Champan JR, Craig JC. Target of rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: a systematic review and meta-analysis of randomized trials. Transplantation. 2006;81:1234-1248.
    • (2006) Transplantation , vol.81 , pp. 1234-1248
    • Webster, A.C.1    Lee, V.W.S.2    Champan, J.R.3    Craig, J.C.4
  • 28
    • 38549115640 scopus 로고    scopus 로고
    • Calcineurin inhibitor-sparing regimens in solid organ transplantation: Focus on improving renal function and nephrotoxicity
    • Flechner SM, Kobashigawa J, Klintmalm G. Calcineurin inhibitor-sparing regimens in solid organ transplantation: focus on improving renal function and nephrotoxicity. Clin Transplant. 2008;22:1-15.
    • (2008) Clin Transplant , vol.22 , pp. 1-15
    • Flechner, S.M.1    Kobashigawa, J.2    Klintmalm, G.3
  • 29
    • 37349034394 scopus 로고    scopus 로고
    • Reduced exposure to calcineurin inhibitors in renal transplantation
    • Ekberg H, Tedesco-Silva H, Demirbas A, et al. Reduced exposure to calcineurin inhibitors in renal transplantation. N Engl J Med. 2007;357:2562-2575.
    • (2007) N Engl J Med , vol.357 , pp. 2562-2575
    • Ekberg, H.1    Tedesco-Silva, H.2    Demirbas, A.3
  • 30
    • 33847717932 scopus 로고    scopus 로고
    • Mycophenolate mofetil/sirolimus compared to other common immunosuppressive regimens in kidney transplantation
    • Srinivas TR, Schold JD, Guerra G, Eagan A, Bucci CM, Meier-Kriesche HU. Mycophenolate mofetil/sirolimus compared to other common immunosuppressive regimens in kidney transplantation. Am J Transplant. 2007;7:586-594.
    • (2007) Am J Transplant , vol.7 , pp. 586-594
    • Srinivas, T.R.1    Schold, J.D.2    Guerra, G.3    Eagan, A.4    Bucci, C.M.5    Meier-Kriesche, H.U.6
  • 31
    • 41149159682 scopus 로고    scopus 로고
    • Prospective comparison of the use of sirolimus and cyclosporine in recipients of a kidney from an expanded criteria donor
    • Durrbach A, Rostaing L, Tricot L, et al. Prospective comparison of the use of sirolimus and cyclosporine in recipients of a kidney from an expanded criteria donor. Transplantation. 2008;85:486-490.
    • (2008) Transplantation , vol.85 , pp. 486-490
    • Durrbach, A.1    Rostaing, L.2    Tricot, L.3
  • 32
    • 0037341439 scopus 로고    scopus 로고
    • Kidney function and morphology after short-term combination therapy with cyclosporine A, tacrolimus and sirolimus in the rat
    • Nielsen FT, Ottosen P, Starklint H, Dieperink H. Kidney function and morphology after short-term combination therapy with cyclosporine A, tacrolimus and sirolimus in the rat. Nephrol Dial Transplant. 2003;18(3):491-496.
    • (2003) Nephrol Dial Transplant , vol.18 , Issue.3 , pp. 491-496
    • Nielsen, F.T.1    Ottosen, P.2    Starklint, H.3    Dieperink, H.4
  • 33
    • 10744221884 scopus 로고    scopus 로고
    • Long-term benefits with sirolimus-based therapy after early cyclosporine withdrawal
    • Kreis H, Oberbauer R, Campistol JM, et al. Long-term benefits with sirolimus-based therapy after early cyclosporine withdrawal. J Am Soc Nephrol. 2004;15:809-817.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 809-817
    • Kreis, H.1    Oberbauer, R.2    Campistol, J.M.3
  • 34
    • 21644457432 scopus 로고    scopus 로고
    • Early cyclosporine withdrawal from a sirolimus-based regimen results in better renal allograft survival and renal function at 48 months after transplantation
    • Oberbauer R, Segolini G, Campistol JM, et al. Early cyclosporine withdrawal from a sirolimus-based regimen results in better renal allograft survival and renal function at 48 months after transplantation. Transpl Int. 2005;18:22-28.
    • (2005) Transpl Int , vol.18 , pp. 22-28
    • Oberbauer, R.1    Segolini, G.2    Campistol, J.M.3
  • 35
    • 2942534405 scopus 로고    scopus 로고
    • Sirolimus-based therapy following early cyclosporine withdrawal provides significantly improved renal histology and function at 3 years
    • Mota A, Arias M, Taskinen EI, et al. Sirolimus-based therapy following early cyclosporine withdrawal provides significantly improved renal histology and function at 3 years. Am J Transplant. 2004;4:953-961.
    • (2004) Am J Transplant , vol.4 , pp. 953-961
    • Mota, A.1    Arias, M.2    Taskinen, E.I.3
  • 36
    • 56049108213 scopus 로고    scopus 로고
    • Efficacy and safety of mycophenolate mofetil (MMF)/sirolimus (SRL) maintenance therapy after calcineurin inhibitor (CNI) withdrawal in renal transplant recipients: Final results of the Spare-the-Nephron (STN) trial [abstract]
    • Pearson TC, Mulgaonkar S, Patel A, et al. Efficacy and safety of mycophenolate mofetil (MMF)/sirolimus (SRL) maintenance therapy after calcineurin inhibitor (CNI) withdrawal in renal transplant recipients: final results of the Spare-the-Nephron (STN) trial [abstract]. Am J Transplant. 2008;8(Suppl 2):213.
    • (2008) Am J Transplant , vol.8 , Issue.SUPPL. 2 , pp. 213
    • Pearson, T.C.1    Mulgaonkar, S.2    Patel, A.3
  • 37
    • 65249134974 scopus 로고    scopus 로고
    • Efficacy on renal function of early conversion from cyclosporine to sirolimus 3 months after renal transplantation: Concept study
    • Lebranchu Y, Thierry A, Toupance O, et al. Efficacy on renal function of early conversion from cyclosporine to sirolimus 3 months after renal transplantation: Concept study. Am J Transplant. 2009;9:1115-1123.
    • (2009) Am J Transplant , vol.9 , pp. 1115-1123
    • Lebranchu, Y.1    Thierry, A.2    Toupance, O.3
  • 38
    • 33645945017 scopus 로고    scopus 로고
    • Rapamycin for treatment of chronic allograft nephropathy in renal transplant patients
    • Stallone G, Infante B, Schena A, et al. Rapamycin for treatment of chronic allograft nephropathy in renal transplant patients. J Am Soc Nephrol. 2005;16:3755-3762.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3755-3762
    • Stallone, G.1    Infante, B.2    Schena, A.3
  • 39
    • 38149095060 scopus 로고    scopus 로고
    • Rapamycin inhibits PAI-1 expression and reduces interstitial fibrosis and glomerulosclerosis in chronic allograft nephropathy
    • Pontrelli P, Rossini M, Infante B, et al. Rapamycin inhibits PAI-1 expression and reduces interstitial fibrosis and glomerulosclerosis in chronic allograft nephropathy. Transplantation. 2008;85:125-134.
    • (2008) Transplantation , vol.85 , pp. 125-134
    • Pontrelli, P.1    Rossini, M.2    Infante, B.3
  • 40
    • 33846334522 scopus 로고    scopus 로고
    • Evaluation of the efficacy and safety of a slow conversion from calcineurin inhibitor- to sirolimus-based therapies in maintenance renal-transplant patients presenting with moderate renal insufficiency
    • Kamar N, Frimat L, Blancho G, Wolff P, Delahousse M, Rostaing L. Evaluation of the efficacy and safety of a slow conversion from calcineurin inhibitor- to sirolimus-based therapies in maintenance renal-transplant patients presenting with moderate renal insufficiency. Transpl Int. 2007;20:128-134.
    • (2007) Transpl Int , vol.20 , pp. 128-134
    • Kamar, N.1    Frimat, L.2    Blancho, G.3    Wolff, P.4    Delahousse, M.5    Rostaing, L.6
  • 41
    • 27644439969 scopus 로고    scopus 로고
    • Long-term results in renal transplant patients with allograft dysfunction after switching from calcineurin inhibitors to sirolimus
    • Bumbea V, Kamar N, Ribes D, et al. Long-term results in renal transplant patients with allograft dysfunction after switching from calcineurin inhibitors to sirolimus. Nephrol Dial Transplant. 2005;20:2517-2523.
    • (2005) Nephrol Dial Transplant , vol.20 , pp. 2517-2523
    • Bumbea, V.1    Kamar, N.2    Ribes, D.3
  • 42
    • 33644696712 scopus 로고    scopus 로고
    • Three-year efficacy and safety results from a study of everolimus versus mycophenolate mofetil in de novo renal transplant patients
    • Vitko S, Margreiter R, Weimar W, et al. Three-year efficacy and safety results from a study of everolimus versus mycophenolate mofetil in de novo renal transplant patients. Am J Transplant. 2005;5:2521-2530.
    • (2005) Am J Transplant , vol.5 , pp. 2521-2530
    • Vitko, S.1    Margreiter, R.2    Weimar, W.3
  • 43
    • 16244378141 scopus 로고    scopus 로고
    • Everolimus versus mycophenolate mofetil in the prevention of rejection in de novo renal transplant recipients: A 3-year randomized, multicenter, phase III study
    • Lorber MI, Mulgaonkar S, Butt KM, et al. Everolimus versus mycophenolate mofetil in the prevention of rejection in de novo renal transplant recipients: a 3-year randomized, multicenter, phase III study. Transplantation. 2005;80:244-252.
    • (2005) Transplantation , vol.80 , pp. 244-252
    • Lorber, M.I.1    Mulgaonkar, S.2    Butt, K.M.3
  • 44
    • 3943072739 scopus 로고    scopus 로고
    • 156 Study Group. Everolimus and reduced-exposure cyclosporine in de novo renal-transplant recipients: A three-year phase II, randomized, multicenter, open-label study
    • Nashan B, Curtis J, Ponticelli C, Mourad G, Jaffe J, Haas T; 156 Study Group. Everolimus and reduced-exposure cyclosporine in de novo renal-transplant recipients: a three-year phase II, randomized, multicenter, open-label study. Transplantation. 2004;78:1332-1340.
    • (2004) Transplantation , vol.78 , pp. 1332-1340
    • Nashan, B.1    Curtis, J.2    Ponticelli, C.3    Mourad, G.4    Jaffe, J.5    Haas, T.6
  • 45
    • 41149117599 scopus 로고    scopus 로고
    • Multicenter, randomized study of the use of everolimus with tacrolimus after renal transplantation demonstrates its effectiveness
    • Chan L, Greenstein S, Hardy MA, et al. Multicenter, randomized study of the use of everolimus with tacrolimus after renal transplantation demonstrates its effectiveness. Transplantation. 2008;85:821-826.
    • (2008) Transplantation , vol.85 , pp. 821-826
    • Chan, L.1    Greenstein, S.2    Hardy, M.A.3
  • 46
    • 4744368628 scopus 로고    scopus 로고
    • Everolimus therapeutic concentration range defined from a prospective trial with reduced-exposure cyclosporine in de novo kidney transplantation
    • Kovarik JM, Tedesco H, Pascual J, et al. Everolimus therapeutic concentration range defined from a prospective trial with reduced-exposure cyclosporine in de novo kidney transplantation. Ther Drug Monit. 2004;26:499-505.
    • (2004) Ther Drug Monit , vol.26 , pp. 499-505
    • Kovarik, J.M.1    Tedesco, H.2    Pascual, J.3
  • 47
    • 33744457937 scopus 로고    scopus 로고
    • Disassociation between risk of graft loss and risk of non-Hodgkin lymphoma with induction agents in renal transplant recipients
    • Opelz G, Naujokat C, Daniel V, Terness P, Döhler B. Disassociation between risk of graft loss and risk of non-Hodgkin lymphoma with induction agents in renal transplant recipients. Transplantation. 2006;81:1227-1233.
    • (2006) Transplantation , vol.81 , pp. 1227-1233
    • Opelz, G.1    Naujokat, C.2    Daniel, V.3    Terness, P.4    Döhler, B.5
  • 49
    • 34548854267 scopus 로고    scopus 로고
    • Renal cell carcinoma in transplant recipients with acquired cystic kidney disease
    • Schwarz A, Vatandslar S, Merkel S, Haller H. Renal cell carcinoma in transplant recipients with acquired cystic kidney disease. Clin J Am Soc Nephrol. 2007;2:750-756.
    • (2007) Clin J Am Soc Nephrol , vol.2 , pp. 750-756
    • Schwarz, A.1    Vatandslar, S.2    Merkel, S.3    Haller, H.4
  • 50
    • 33845711356 scopus 로고    scopus 로고
    • Cancer incidence before and after kidney transplantation
    • Vajdic CM, McDonald SP, McCredie MR, et al. Cancer incidence before and after kidney transplantation. JAMA. 2006;296:2823-2831.
    • (2006) JAMA , vol.296 , pp. 2823-2831
    • Vajdic, C.M.1    McDonald, S.P.2    McCredie, M.R.3
  • 51
    • 49649111192 scopus 로고    scopus 로고
    • Kaposi's sarcoma and mTOR: A crossroad between viral infection neoangiogenesis and immunosuppression
    • Stallone G, Infante B, Grandaliano G, Schena FP, Gesualdo L. Kaposi's sarcoma and mTOR: a crossroad between viral infection neoangiogenesis and immunosuppression. Transpl Int. 2008;21:825-832.
    • (2008) Transpl Int , vol.21 , pp. 825-832
    • Stallone, G.1    Infante, B.2    Grandaliano, G.3    Schena, F.P.4    Gesualdo, L.5
  • 52
    • 34250175840 scopus 로고    scopus 로고
    • Kaposi sarcoma in renal transplant recipients: The impact of proliferation signal inhibitors
    • Campistol JM, Schena FP. Kaposi sarcoma in renal transplant recipients: the impact of proliferation signal inhibitors. Nephrol Dial Transplant. 2007;22(Suppl 1):i17-i22.
    • (2007) Nephrol Dial Transplant , vol.22 , Issue.SUPPL. 1
    • Campistol, J.M.1    Schena, F.P.2
  • 53
    • 33646820007 scopus 로고    scopus 로고
    • Subsequent skin cancers in kidney and heart transplant recipients after the first squamous cell carcinoma
    • Euvrard S, Kanitakis J, Decullier E, et al. Subsequent skin cancers in kidney and heart transplant recipients after the first squamous cell carcinoma. Transplantation. 2006;81:1093-1100.
    • (2006) Transplantation , vol.81 , pp. 1093-1100
    • Euvrard, S.1    Kanitakis, J.2    Decullier, E.3
  • 54
    • 27544505190 scopus 로고    scopus 로고
    • Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck
    • Amornphimoltham P, Patel V, Sodhi A, et al. Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck. Cancer Res. 2005;65:9953-9961.
    • (2005) Cancer Res , vol.65 , pp. 9953-9961
    • Amornphimoltham, P.1    Patel, V.2    Sodhi, A.3
  • 55
    • 58149355295 scopus 로고    scopus 로고
    • Inhibition of mammalian target of rapamycin by rapamycin causes the regression of carcinogen-induced skin tumor lesions
    • Amornphimoltham P, Leelahavanichkul K, Molinolo A, Patel V, Gutkind JS. Inhibition of mammalian target of rapamycin by rapamycin causes the regression of carcinogen-induced skin tumor lesions. Clin Cancer Res. 2008;14:8094-8101.
    • (2008) Clin Cancer Res , vol.14 , pp. 8094-8101
    • Amornphimoltham, P.1    Leelahavanichkul, K.2    Molinolo, A.3    Patel, V.4    Gutkind, J.S.5
  • 56
    • 60849100558 scopus 로고    scopus 로고
    • Epstein-Barr virus, rapamycin, and host immune responses
    • Krams SM, Martinez OM. Epstein-Barr virus, rapamycin, and host immune responses. Curr Opin Organ Transplant. 2008;13:563-568.
    • (2008) Curr Opin Organ Transplant , vol.13 , pp. 563-568
    • Krams, S.M.1    Martinez, O.M.2
  • 57
    • 34250156714 scopus 로고    scopus 로고
    • Post-transplant lymphoproliferative disorder: The potential of proliferation signal inhibitors
    • Pascual J. Post-transplant lymphoproliferative disorder: the potential of proliferation signal inhibitors. Nephrol Dial Transplant. 2007;22(Suppl 1):i27-i35.
    • (2007) Nephrol Dial Transplant , vol.22 , Issue.SUPPL. 1
    • Pascual, J.1
  • 58
    • 2542609091 scopus 로고    scopus 로고
    • Wound-healing complicates after kidney transplantation: A prospective, randomized comparison of sirolimus and tacrolimus
    • Dean PG, Lund WJ, Larson TS, et al. Wound-healing complicates after kidney transplantation: a prospective, randomized comparison of sirolimus and tacrolimus. Transplantation. 2004;77:1555-1561.
    • (2004) Transplantation , vol.77 , pp. 1555-1561
    • Dean, P.G.1    Lund, W.J.2    Larson, T.S.3
  • 59
    • 0042863282 scopus 로고    scopus 로고
    • Comparison of sirolimus vs mycophenolate mofetil on surgical complications and wound healing in adult kidney transplantation
    • Valente JF, Hricik D, Weigel K, et al. Comparison of sirolimus vs mycophenolate mofetil on surgical complications and wound healing in adult kidney transplantation. Am J Transplant. 2003;3:1128-1134.
    • (2003) Am J Transplant , vol.3 , pp. 1128-1134
    • Valente, J.F.1    Hricik, D.2    Weigel, K.3
  • 60
    • 4644360727 scopus 로고    scopus 로고
    • Induction sirolimus and delayed graft function after deceased donor kidney transplantation in the United States
    • Simon JF, Swanson SJ, Agodoa LY, Cruess DF, Bohen EM, Abbott K. Induction sirolimus and delayed graft function after deceased donor kidney transplantation in the United States. Am J Nephrol. 2004;24:393-401.
    • (2004) Am J Nephrol , vol.24 , pp. 393-401
    • Simon, J.F.1    Swanson, S.J.2    Agodoa, L.Y.3    Cruess, D.F.4    Bohen, E.M.5    Abbott, K.6
  • 61
    • 4143122229 scopus 로고    scopus 로고
    • Comparison of outcomes after delayed graft function: Sirolimus-based versus other calcineurin-inhibitor sparing induction immunosuppression regimens
    • McTaggart RA, Tomlanovich S, Bostrom A, Roberts JP, Feng S. Comparison of outcomes after delayed graft function: sirolimus-based versus other calcineurin-inhibitor sparing induction immunosuppression regimens. Transplantation. 2004;78:475-480.
    • (2004) Transplantation , vol.78 , pp. 475-480
    • McTaggart, R.A.1    Tomlanovich, S.2    Bostrom, A.3    Roberts, J.P.4    Feng, S.5
  • 62
    • 20044379939 scopus 로고    scopus 로고
    • Cutaneous adverse events in renal transplant recipients receiving sirolimus-based therapy
    • Mahé E, Morelon E, Lechaton S, et al. Cutaneous adverse events in renal transplant recipients receiving sirolimus-based therapy. Transplantation. 2005;79:476-482.
    • (2005) Transplantation , vol.79 , pp. 476-482
    • Mahé, E.1    Morelon, E.2    Lechaton, S.3
  • 63
    • 33847743084 scopus 로고    scopus 로고
    • Clobetasol ameliorates aphthous ulceration in renal transplant patients on sirolimus
    • Chuang P, Langone AJ. Clobetasol ameliorates aphthous ulceration in renal transplant patients on sirolimus. Am J Transplant. 2007;7:714-717.
    • (2007) Am J Transplant , vol.7 , pp. 714-717
    • Chuang, P.1    Langone, A.J.2
  • 64
    • 10044267849 scopus 로고    scopus 로고
    • Comparative effects of sirolimus and mycophenolate mofetil on erythropoiesis in kidney transplant patients
    • Augustine JJ, Knauss TC, Schulak JA, Bodziak KA, Siegel C, Hricik DE. Comparative effects of sirolimus and mycophenolate mofetil on erythropoiesis in kidney transplant patients. Am J Transplant. 2004;4:2001-2006.
    • (2004) Am J Transplant , vol.4 , pp. 2001-2006
    • Augustine, J.J.1    Knauss, T.C.2    Schulak, J.A.3    Bodziak, K.A.4    Siegel, C.5    Hricik, D.E.6
  • 65
    • 52449124228 scopus 로고    scopus 로고
    • Reduction in erythropoietin resistance after conversion from sirolimus to enteric coated mycophenolate sodium
    • Augustine JJ, Rodriguez V, Padiyar A, Bodziak KA, Schulak JA, Hricik DE. Reduction in erythropoietin resistance after conversion from sirolimus to enteric coated mycophenolate sodium. Transplantation. 2008;86:548-553.
    • (2008) Transplantation , vol.86 , pp. 548-553
    • Augustine, J.J.1    Rodriguez, V.2    Padiyar, A.3    Bodziak, K.A.4    Schulak, J.A.5    Hricik, D.E.6
  • 66
    • 33749873763 scopus 로고    scopus 로고
    • Sirolimus interferes with iron homeostasis in renal transplant recipients
    • Maiorano A, Stallone G, Schena A, et al. Sirolimus interferes with iron homeostasis in renal transplant recipients. Transplantation. 2006;82:908-912.
    • (2006) Transplantation , vol.82 , pp. 908-912
    • Maiorano, A.1    Stallone, G.2    Schena, A.3
  • 67
    • 33644873957 scopus 로고    scopus 로고
    • Marked erythrocyte microcytosis under primary immunosuppression with sirolimus
    • Kim MJ, Mayr M, Pechula M, Steiger J, Dickenmann M. Marked erythrocyte microcytosis under primary immunosuppression with sirolimus. Transpl Int. 2006;19:12-18.
    • (2006) Transpl Int , vol.19 , pp. 12-18
    • Kim, M.J.1    Mayr, M.2    Pechula, M.3    Steiger, J.4    Dickenmann, M.5
  • 68
    • 34548859562 scopus 로고    scopus 로고
    • Sirolimus: Defining nephrotoxicity in the renal transplant recipient
    • Tomlanovich SJ, Vincenti F. Sirolimus: defining nephrotoxicity in the renal transplant recipient. Clin J Am Soc Nephrol. 2007;2:198-199.
    • (2007) Clin J Am Soc Nephrol , vol.2 , pp. 198-199
    • Tomlanovich, S.J.1    Vincenti, F.2
  • 70
    • 31544461508 scopus 로고    scopus 로고
    • Conversion from calcineurin inhibitors to sirolimus in chronic allograft dysfunction: Changes in glomerular haemodynamics and proteinuria
    • Saurina A, Campistol JM, Piera C, et al. Conversion from calcineurin inhibitors to sirolimus in chronic allograft dysfunction: Changes in glomerular haemodynamics and proteinuria. Nephrol Dial Transplant. 2006;21:488-493.
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 488-493
    • Saurina, A.1    Campistol, J.M.2    Piera, C.3
  • 71
    • 33750008433 scopus 로고    scopus 로고
    • Increase of proteinuria after conversion from calcineurin inhibitor to sirolimus-based treatment in kidney transplant patients with chronic allograft dysfunction
    • Ruiz JC, Campistol JM, Sanchez-Fructuoso A, et al. Increase of proteinuria after conversion from calcineurin inhibitor to sirolimus-based treatment in kidney transplant patients with chronic allograft dysfunction. Nephrol Dial Transplant. 2006;21:3252-3257.
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 3252-3257
    • Ruiz, J.C.1    Campistol, J.M.2    Sanchez-Fructuoso, A.3
  • 72
    • 33748928436 scopus 로고    scopus 로고
    • Proteinuria following conversion from azathioprine to sirolimus in renal transplant recipients
    • van den Akkher JM, Wetzels JFM, Hoitsma AJ. Proteinuria following conversion from azathioprine to sirolimus in renal transplant recipients. Kidney Int. 2006;70:1355-1357.
    • (2006) Kidney Int , vol.70 , pp. 1355-1357
    • van den Akkher, J.M.1    Wetzels, J.F.M.2    Hoitsma, A.J.3
  • 73
    • 20444445998 scopus 로고    scopus 로고
    • Unusual post-transplantation recurrence of focal segmental glomerulosclerosis which resolved with cyclosporine but not with sirolimus
    • Skhiri H, Morelon E, Noel LH, et al. Unusual post-transplantation recurrence of focal segmental glomerulosclerosis which resolved with cyclosporine but not with sirolimus. Transpl Int. 2005;8:458-460.
    • (2005) Transpl Int , vol.8 , pp. 458-460
    • Skhiri, H.1    Morelon, E.2    Noel, L.H.3
  • 74
    • 34548851984 scopus 로고    scopus 로고
    • High sirolimus levels may induce focal segmental glomerulosclerosis de novo
    • Letavernier E, Bruneval P, Mandet C, et al. High sirolimus levels may induce focal segmental glomerulosclerosis de novo. Clin J Am Soc Nephrol. 2007;2:326-333.
    • (2007) Clin J Am Soc Nephrol , vol.2 , pp. 326-333
    • Letavernier, E.1    Bruneval, P.2    Mandet, C.3
  • 75
  • 76
    • 58149159562 scopus 로고    scopus 로고
    • Everolimus-associated pneumonitis in three heart transplant recipients
    • Otton J, Hayward CS, Keogh AM, et al. Everolimus-associated pneumonitis in three heart transplant recipients. J Heart Lung Transplant. 2009;28:104-106.
    • (2009) J Heart Lung Transplant , vol.28 , pp. 104-106
    • Otton, J.1    Hayward, C.S.2    Keogh, A.M.3
  • 77
    • 33645833623 scopus 로고    scopus 로고
    • Sirolimus-associated pneumonitis: 24 cases in renal transplant recipients
    • Champion L, Stern M, Israël-Biet D, et al. Sirolimus-associated pneumonitis: 24 cases in renal transplant recipients. Ann Intern Med. 2006;144:505-509.
    • (2006) Ann Intern Med , vol.144 , pp. 505-509
    • Champion, L.1    Stern, M.2    Israël-Biet, D.3
  • 78
    • 33847235398 scopus 로고    scopus 로고
    • Gonadal impact of target of rapamycin inhibitors (sirolimus and everolimus) in male patients: An overview
    • Huyghe E, Zairi A, Nohra J, Kamar N, Plante P, Rostaing L. Gonadal impact of target of rapamycin inhibitors (sirolimus and everolimus) in male patients: an overview. Transpl Int. 2007;20:305-311.
    • (2007) Transpl Int , vol.20 , pp. 305-311
    • Huyghe, E.1    Zairi, A.2    Nohra, J.3    Kamar, N.4    Plante, P.5    Rostaing, L.6
  • 79
    • 0742284031 scopus 로고    scopus 로고
    • Fritsche L, Budde K, Dragun D, Einecke G, Diekmann F, Neumayer HH. Testosterone concentrations and sirolimus in male renal transplant patients. Am J Transplant. 2004;4:130-131.3
    • Fritsche L, Budde K, Dragun D, Einecke G, Diekmann F, Neumayer HH. Testosterone concentrations and sirolimus in male renal transplant patients. Am J Transplant. 2004;4:130-131.3
  • 80
    • 47249138206 scopus 로고    scopus 로고
    • Sirolimus may reduce fertility in male renal transplant recipients
    • Zuber J, Anglicheau D, Elie C, et al. Sirolimus may reduce fertility in male renal transplant recipients. Am J Transplant. 2008;8:1471-1479.
    • (2008) Am J Transplant , vol.8 , pp. 1471-1479
    • Zuber, J.1    Anglicheau, D.2    Elie, C.3
  • 81
    • 47249114832 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibitor dyslipidemia in kidney transplant recipients
    • Kasiske BL, de Mattos A, Flechner SM, et al. Mammalian target of rapamycin inhibitor dyslipidemia in kidney transplant recipients. Am J Transplant. 2008;8:1384-1392.
    • (2008) Am J Transplant , vol.8 , pp. 1384-1392
    • Kasiske, B.L.1    de Mattos, A.2    Flechner, S.M.3
  • 82
    • 1942471969 scopus 로고    scopus 로고
    • Lymphedema associated with sirolimus in renal transplant recipients
    • Aboujaoude W, Milgrom ML, Govani MV. Lymphedema associated with sirolimus in renal transplant recipients. Transplantation. 2004;77:1094-1096.
    • (2004) Transplantation , vol.77 , pp. 1094-1096
    • Aboujaoude, W.1    Milgrom, M.L.2    Govani, M.V.3
  • 83
    • 66149146298 scopus 로고    scopus 로고
    • Sirolimus-associated lymphoedema: Eight new cases and a proposed mechanism
    • Desai N, Heenan S, Mortimer PS. Sirolimus-associated lymphoedema: eight new cases and a proposed mechanism. Br J Dermatol. 2009;160:1322-1326.
    • (2009) Br J Dermatol , vol.160 , pp. 1322-1326
    • Desai, N.1    Heenan, S.2    Mortimer, P.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.