Negative feedback loop of BRCA1-BARD1 ubiquitin ligase on estrogen receptor alpha stability and activity antagonized by cancer-associated isoform of BARD1

International Journal of Biochemistry and Cell Biology

Volumn 42, Issue 5, 2010, Pages 693-700

  Dizin, Eva ^a   Irminger Finger, Irmgard ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

BARD1; BRCA1; Breast cancer; Estrogen receptor alpha; Estrogen signaling; Ovarian cancer; Ubiquitin ligase

Indexed keywords

BRCA1 ASSOCIATED RING DOMAIN PROTEIN 1; BRCA1 PROTEIN; ESTROGEN RECEPTOR ALPHA; ISOPROTEIN; RING FINGER PROTEIN; UBIQUITIN PROTEIN LIGASE;

AMINO TERMINAL SEQUENCE; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VIVO CULTURE; NEGATIVE FEEDBACK; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UBIQUITINATION; UPREGULATION;

BRCA1 PROTEIN; BREAST NEOPLASMS; CELL LINE, TUMOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEEDBACK, PHYSIOLOGICAL; FEMALE; HUMANS; MUTANT PROTEINS; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN ISOFORMS; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN TRANSPORT; RING FINGER DOMAINS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASE COMPLEXES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION; UP-REGULATION; UTERINE CERVICAL NEOPLASMS;

EID: 77649339184     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2009.12.025     Document Type: Article

References (23)

1. Choudhury A.D., Xu H., and Baer R. Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression. J Biol Chem 279 (2004) 33909-33918
2. Creekmore A.L., Ziegler Y.S., Boney J.L., and Nardulli A.M. Estrogen receptor alpha regulates expression of the breast cancer 1 associated ring domain 1 (BARD1) gene through intronic DNA sequence. Mol Cell Endocrinol 267 (2007) 106-115
3. Dizin E., Gressier C., Magnard C., Ray H., Decimo D., Ohlmann T., et al. BRCA1 interacts with poly(A)-binding protein: implication of BRCA1 in translation regulation. J Biol Chem 281 (2006) 24236-24246
4. Eakin C.M., Maccoss M.J., Finney G.L., and Klevit R.E. Estrogen receptor alpha is a putative substrate for the BRCA1 ubiquitin ligase. Proc Natl Acad Sci USA 104 (2007) 5794-5799
5. Fan S., Ma Y.X., Wang C., Yuan R.Q., Meng Q., Wang J.A., et al. Role of direct interaction in BRCA1 inhibition of estrogen receptor activity. Oncogene 20 (2001) 77-87
6. Feki A., Jefford C.E., Berardi P., Wu J.Y., Cartier L., Krause K.H., et al. BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase. Oncogene 24 (2005) 3726-3736
7. Fox III D., Le Trong I., Rajagopal P., Brzovic P.S., Stenkamp R.E., and Klevit R.E. Crystal structure of the BARD1 ankyrin repeat domain and its functional consequences. J Biol Chem 283 (2008) 21179-21186
8. Hashizume R., Fukuda M., Maeda I., Nishikawa H., Oyake D., Yabuki Y., et al. The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation. J Biol Chem 276 (2001) 14537-14540
9. Irminger-Finger I., and Jefford C.E. Is there more to BARD1 than BRCA1?. Nat Rev Cancer 6 (2006) 382-391
10. Kleiman F.E., Wu-Baer F., Fonseca D., Kaneko S., Baer R., and Manley J.L. BRCA1/BARD1 inhibition of mRNA 3′ processing involves targeted degradation of RNA polymerase II. Genes Dev 19 (2005) 1227-1237
11. Lee E.Y. Promotion of BRCA1-associated triple-negative breast cancer by ovarian hormones. Curr Opin Obstet Gynecol 20 (2008) 68-73
12. Li L., Ryser S., Dizin E., Pils D., Krainer M., Jefford C.E., et al. Oncogenic BARD1 isoforms expressed in gynecological cancers. Cancer Res 67 (2007) 11876-11885
13. Ma Y., Fan S., Hu C., Meng Q., Fuqua S.A., Pestell R.G., et al. BRCA1 regulates acetylation and ubiquitination of estrogen receptor-{alpha}. Mol Endocrinol (2009)
14. Miki Y., Swensen J., Shattuck-Eidens D., Futreal P.A., Harshman K., Tavtigian S., et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266 (1994) 66-71
15. Petz L.N., and Nardulli A.M. Sp1 binding sites and an estrogen response element half-site are involved in regulation of the human progesterone receptor A promoter. Mol Endocrinol 14 (2000) 972-985
16. Ryser S., Dizin E.C., Jefford B., Delaval A., Christodoulidou N., Gagos S., et al. Distinct roles of BARD1 isoforms in mitosis: full length BARD1 mediates Aurora B degradation, cancer-associated BARD1β scaffolds Aurora B and BRCA2. Cancer Res 69 (2009) 1125-1134
17. Sato K., Hayami R., Wu W., Nishikawa T., Nishikawa H., Okuda Y., et al. Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase. J Biol Chem 279 (2004) 30919-30922
18. Scully R., Chen J., Ochs R.L., Keegan K., Hoekstra M., Feunteun J., et al. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell 90 (1997) 425-435
19. Tembe V., and Henderson B.R. BARD1 translocation to mitochondria correlates with Bax oligomerization, loss of mitochondrial membrane potential and apoptosis. J Biol Chem (2007)
20. Tsuzuki M., Wu W., Nishikawa H., Hayami R., Oyake D., Yabuki Y., et al. A truncated splice variant of human BARD1 that lacks the RING finger and ankyrin repeats. Cancer Lett 233 (2006) 108-116
21. Wu J.Y., Vlastos A.T., Pelte M.F., Caligo M.A., Bianco A., Krause K.H., et al. Aberrant expression of BARD1 in breast and ovarian cancers with poor prognosis. Int J Cancer 118 (2006) 1215-1226
22. Wu L.C., Wang Z.W., Tsan J.T., Spillman M.A., Phung A., Xu X.L., et al. Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nat Genet 14 (1996) 430-440
23. Xu J., Fan S., and Rosen E.M. Regulation of the estrogen-inducible gene expression profile by the breast cancer susceptibility gene BRCA1. Endocrinology 146 (2005) 2031-2047