Design and development of a method for the reduction of infectious pathogen load and inactivation of white blood cells in whole blood products

Biologicals

Volumn 38, Issue 1, 2010, Pages 20-30

  Goodrich, Raymond P ^a   Doane, Suzann ^a   Reddy, Heather L ^a  

^a CaridianBCT Biotechnologies   (United States)

Author keywords

Pathogen reduction; Riboflavin; UV light; Whole blood

Indexed keywords

RIBOFLAVIN;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; BIOSAFETY; BIOTECHNOLOGY; BLOOD CHEMISTRY; CONTROLLED STUDY; ERYTHROCYTE; HEMATOLOGICAL PROCEDURES; IMMOBILIZED CELL; ISOTOPE LABELING; LEUKOCYTE; NONHUMAN; PATHOGEN REDUCTION TECHNOLOGY; PHOTOCHEMISTRY; PLASMA; PRIORITY JOURNAL; THROMBOCYTE; ULTRAVIOLET RADIATION;

ANIMALS; BLOOD; BLOOD PRESERVATION; BLOOD-BORNE PATHOGENS; COLONY COUNT, MICROBIAL; DISINFECTION; LEUKOCYTES; PAPIO; QUALITY CONTROL; RESEARCH DESIGN; RIBOFLAVIN; ULTRAVIOLET RAYS; VIRAL LOAD; VIRUS INACTIVATION;

EID: 77649336975     PISSN: 10451056     EISSN: 10958320     Source Type: Journal    
DOI: 10.1016/j.biologicals.2009.10.016     Document Type: Article

References (21)

1. Allain J.P., Bianco C., Blajchman M.A., Brecher M.E., Busch M., Leiby D., et al. Protecting the blood supply from emerging pathogens: the role of pathogen inactivation. Transfus Med Rev 19 (2005) 110-126
2. Seghatchian J., and de Sousa G. Pathogen-reduction systems for blood components: the current position and future trends. Transfus Apheresis Sci 35 (2006) 189-196
3. Horowitz B., Bonomo R., Prince A.M., Chin S.N., Brotman B., and Shulman R.W. Solvent/detergent-treated plasma: a virus-inactivated substitute for fresh frozen plasma. Blood 79 (1992) 826
4. Wagner S.J., Robinette D., Storry J., Chen S.Y., Shumaker J., and Benade L. Differential sensitivities of viruses in red cell suspensions to methylene blue photosensitization. Transfusion 34 (1994) 521-526
5. Klein-Struckmeier A., and Mohr H. Photodynamic virus inactivation of thrombocyte concentrates by phenothiazine dyes. Beitr Infus Ther Transfus Med 34 (1997) 43-47
6. Pelletier J.P., Transue S., and Snyder E.L. Pathogen inactivation techniques. Best Pract Res Clin Haematol 19 (2006) 205-242
7. Kehe K., Balszuweit F., Steinritz D., and Thiermann H. Molecular toxicology of sulfur mustard-induced cutaneous inflammation and blistering. Toxicology 263 (2009) 12-19
8. Conlan M.G., Stassinopoulos A., Garratty G., Wages D., Corash L., Lindsey W., Sloan S.R., et al. Antibody formation to S-303-treated RBCs in the setting of chronic RBC transfusions. Blood 104 (2004) 112a-113a
9. AuBuchon J.P., Pickard C.A., Herschel L.H., Roger J.C., Tracy J.E., Purmal A., et al. Production of pathogen-inactivated RBC concentrates using PEN110 chemistry: a phase I clinical study. Transfusion 42 (2002) 146-152
10. Goodrich R.P., Edrich R.A., Li J., Seghatchian J., and The Mirasol P.R.T. System for pathogen reduction of platelets and plasma: an overview of current status and future trends. Transfus Apheresis Sci 35 (2006) 5-17
11. Kumar V., Lockerbie O., Keil S.D., Ruane P.H., Platz M.S., Martin C.B., et al. Riboflavin and UV-light based pathogen reduction: extent and consequence of DNA damage at the molecular level. Photochem Photobiol 80 (2004) 15-21
12. Martin C.B., Wilfong E., Ruane P., Goodrich R., and Platz M. An action spectrum of the riboflavin-photosensitized inactivation of lambda phage. Photochem Photobiol 81 (2005) 474-480
13. Goodrich R.P., Gilmour D., Hovenga N., and Keil S.D. A laboratory comparison of pathogen reduction technology treatment and culture of platelet products for addressing bacterial contamination concerns. Transfusion 49 (2009) 1205-1216
14. Brecher M.E., and Hay S.N. Bacterial contamination of blood components. Clin Microbiol Rev 18 (2005) 195-204
15. Fast L., DiLeone G., Li J., and Goodrich R. Functional inactivation of white blood cells by Mirasol treatment. Transfusion 46 (2006) 642-648
16. Fast L.D., DiLeone G., Cardarelli G., Li J., and Goodrich R. Mirasol PRT treatment of donor leukocytes prevent the development of xenogeneic graft-versus-host disease in Rag2-/-gamma-/- double knockout mice. Transfusion 46 (2006) 1553-1560
17. Goodrich R.P., Murthy K.K., Doane S.K., Fitpatrick C.H., Morrow L.S., Arndt P.A., et al. Evaluation of potential immune response and in vivo survival of riboflavin-ultraviolet light-treated red blood cells in baboons. Transfusion 49 (2009) 64-74
18. Gorton H.J., Warren E.R., Simpson N.A.B., Lyons G.R., and Columb M.O. Thromboelastography identifies sex-related differences in coagulation. Anesth Analg 91 (2000) 1279-1281
19. Moroff G., Sohmer P.R., and Button L.N. Proposed standardization of methods for determining the 24-hour survival of stored red cells. Transfusion 24 (1984) 109-114
20. Beeck H., and Hellstern P. In vitro characterization of solvent/detergent-treated human plasma and of quarantine fresh frozen plasma. Vox Sang 74 Suppl. 1 (1998) 219-223
21. Reddy H.L., Dayan A.D., Cavagnaro J., Gad S., Li J., and Goodrich R.P. Toxicity testing of a novel riboflavin-based technology for pathogen reduction and white blood cell inactivation. Transfus Med Rev 22 (2008) 133-153