Mirasol PRT treatment of donor white blood cells prevents the development of xenogeneic graft-versus-host disease in Rag2-/-γc -/- double knockout mice

Transfusion

Volumn 46, Issue 9, 2006, Pages 1553-1560

  Fast, Loren D ^a   DiLeone, Gilbert ^b   Cardarelli, Gene ^b   Li, Junzhi ^b   Goodrich, Raymond ^b  

^a RHODE ISLAND HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN; INTERLEUKIN 10; RAG2 PROTEIN; RIBOFLAVIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIVISION; CONTROLLED STUDY; DISEASE COURSE; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; LEUKOCYTE; LEUKOCYTE TRANSFUSION; LYMPHOID CELL; MOUSE; NONHUMAN; PHENOTYPE; PHOTOTHERAPY; TRANSFUSION ASSOCIATED GRAFT VERSUS HOST DISEASE;

ANIMALS; ANTIGENS, CD3; CYTOKINES; GAMMA RAYS; GRAFT VS HOST DISEASE; HUMANS; LEUKOCYTE REDUCTION PROCEDURES; LEUKOCYTES; LYMPHOCYTE TRANSFUSION; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; PHOTOSENSITIZING AGENTS; RIBOFLAVIN;

EID: 33748327070     PISSN: 00411132     EISSN: 15372995     Source Type: Journal    
DOI: 10.1111/j.1537-2995.2006.00939.x     Document Type: Article

References (32)

1. Vamvakas EC, Blajchman MA. Deleterious clinical effects of transfusion-associated immunomodulation: fact or fiction? Blood 2001;97:1180-95.
2. Lee JH, Klein H. From leukocyte reduction to leukocyte transfusion: the immunological effects of transfused leukocytes. Bailliere's Clin Hematol 2000;13:585-600.
3. Gould DS, Auchincloss HJ. Direct and indirect recognition: the role of MHC antigens in graft rejection. Immunol Today 1999;20:77-82.
4. -/- double mutant mice. Blood 2003;102:2522-31.
5. Fast L, Semple J, DiLeone G, et al. Inhibition of xenogeneic graft-versus-host disease by PEN110 treatment of donor human peripheral blood mononuclear cells. Transfusion 2004;44:282-5.
6. Mosier D, Guilizia R, Baird S, Wilson D. Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 1988;335:256-9.
7. Barry T, Jones D, Richter C, Haynes B. Successful engraftment of human postnatal thymus in severe combined immune deficient (SCID) mice: differential engraftment of thymic components with irradiation versus anti-asialo GM1 immunosuppressive regimens. J Exp Med 1991;173:167-80.
8. Sandhu J, Gorczynski R, Shpitz B, et al. A human model of xenogeneic graft-versus-host disease in SCID mice engrafted with human peripheral blood lymphocytes. Transplantation 1995;60:179-84.
9. Fraser C, Chen B, Webb S, et al. Circulation of human hematopoietic cells in severe combined immunodeficient mice after Cl2MDP-liposome-mediated macrophage depletion. Blood 1995;86:183-92.
10. Kumar V, Lockerbie O, Ruane P, et al. Riboflavin and UV-light based pathogen reduction: extent and consequences of DNA damage at the molecular. Photochem Photobiol 2004;80:15-21.
11. Fast L, DiLeone GJ, Li J, Goodrich R. Functional inactivation of white blood cells by Mirasol treatment. Transfusion 2006;46:642-8.
12. Fast L, DiLeone G, Edson C, Purmal A. PEN110 treatment functionally inactivates the PBMNCs present in RBC units: comparison to the effects of exposure to gamma irradiation. Transfusion 2002;42:1318-25.
13. Fast L. The effect of exposing murine splenocytes to UVB light, psoralen plus UVA light or gamma-irradiation on in vitro and in vivo immune responses. Transfusion 2003;43:576-83.
14. Alter G, Malenfant J, Altfeld M. CD107a as a functional marker for the identification of natural killer cell activity. J Immunol Methods 2004;294:15-22.
15. Betts M, Brenchley J, Price D, et al. Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J Immunol Methods 2003;281:65-78.
16. Grossman W, Verbsky J, Tollefsen B, et al. Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood 2004;104:2840-8.
17. Grossman W, Verbsky J, Barchet W, et al. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 2004;21:589-601.
18. AuBuchon JI, Herschel L, Roger J, et al. Efficacy of apheresis platelets treated with riboflavin and ultraviolet ight for pathogen reduction. Transfusion 2005;45:1335-41.
19. Ruane P, Edrich R, Gampp D, et al. Photochemical inactivation of selected viruses and bacteria in platelet concentrates using riboflavin and light. Transfusion 2004;44:877-85.
20. Kumar V, Motheral T, Luzniak G, Goodrich R. Mirasol pathogen reduction technology: riboflavin-based plasma process inactivates intracellular and extracellular human immunodeficiency. J Clin Apher 2003;18:84.
21. Goodrich L, Douglas I, Urisote M. Riboflavin photoinactivation procedure inactivates significant levels of bacteria and produces a culture negative product. Transfusion 2002;42:16S.
22. Goodrich LM, Ghielli M, Hansen E, et al. Riboflavin and UV light inactivate enveloped and non-enveloped viruses in platelet concentrates which maintain cell quality. Vox Sang 2002;83:111.
23. Goodrich R. Inactivation of viruses in blood products (platelets, plasma, and red cells). Transfus Clin Biol 2001;8:103S.
24. Andre-Schmutz I, Deist FL, Hacein-Bey-Abina S, et al. Immune reconstitution without graft-versus-host disease after haemopoietic stem-cell transplantation: a phase 1/2 study. Lancet 2002;360:130-7.
25. Ohto H. Gamma radiation does not prevent transfusion-induced HLA alloimmunization. Transfusion 1997;37:878-9.
26. Kamel-Reid S, Dick J. Engraftment of immune-deficient mice with human hematopoietic stem cells. Science 1988;242:1706-9.
27. Mamzer-Bruneel MF, Bourquelot P, Hermine O, Legendre C, Kreis H. Treatment and prognosis of post-transplant lymphoproliferative disease. Ann Transplant 1997;2:42-8.
28. Miura Y, Thoburn CJ, Bright EC, et al. Cytokine and chemokine profiles in autologous graft-versus-host disease (GVHD): interleukin 10 and interferon γ may be critical mediators for the development of autologous GVHD. Blood 2002;100:2650-8.
29. Sprent J, Suth CD, Agus D, et al. Profound atrophy of the bone marrow reflecting major histocompatibility complex class II-restricted destruction of stem cells by CD4+ cells. J Exp Med 1994;180:307-17.
30. Lindahl K, Bach F. Human lymphocytes recognise mouse alloantigens. Nature 1975;254:607-9.
31. Lindahl K, Bach F. Genetic and cellular aspects of xenogeneic mixed leukocyte culture reaction. J Exp Med 1976;144:305-18.
32. Williams SS, Umemoto T, Kida H, Repasky EA, Bankert RB. Engraftment of human peripheral blood leukocytes into severe combined immunodeficient mice results in the long term and dynamic production of human xenoreactive antibodies. J Immunol 1992;149:2830-6.