Anemia of thermal injury: Combined acute blood loss anemia and anemia of critical illness

Journal of Burn Care and Research

Volumn 31, Issue 2, 2010, Pages 229-242

  Posluszny Jr , Joseph A ^a,b   Gamelli, Richard L ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ERYTHROPOIETIN; PHENYLEPHRINE; RECOMBINANT ERYTHROPOIETIN; THROMBIN; ZIDOVUDINE;

ACUTE BLOOD LOSS ANEMIA; ANEMIA; ANEMIA OF CRITICAL ILLNESS; BIOASSAY; BLEEDING; BLOOD TRANSFUSION; BONE MARROW DEPRESSION; BURN; CHRONIC KIDNEY DISEASE; CLINICAL TRIAL; CRITICAL ILLNESS; DISEASE CLASSIFICATION; DYSERYTHROPOIESIS; ERYTHROCYTE CONCENTRATE; GRAFT PERFUSION; HEMODYNAMICS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NUTRITIONAL DEFICIENCY; PHLEBOTOMY; RADIOIMMUNOASSAY; REVIEW; SKIN GRAFT; SURGICAL TECHNIQUE; THERMAL INJURY; TOURNIQUET;

ANEMIA; BLOOD TRANSFUSION; BURNS; CRITICAL ILLNESS; EPINEPHRINE; ERYTHROPOIETIN, RECOMBINANT; HEMORRHAGE; TOURNIQUETS; VASOCONSTRICTOR AGENTS;

EID: 77649302650     PISSN: 1559047X     EISSN: 15590488     Source Type: Journal    
DOI: 10.1097/BCR.0b013e3181d0f618     Document Type: Review

References (108)

1. Deitch EA, Sittig KM. A serial study of the erythropoietic response to thermal injury. Ann Surg 1993;217:293-299
2. Andes WA, Rogers PW, Beason JW, Pruitt BA Jr. The erythropoietin response to the anemia of thermal injury. J Lab Clin Med 1976;88:584-592
3. Harris RL, Cottam GL, Johnston JM, Baxter CR. The pathogenesis of abnormal erythrocyte morphology in burns. J Trauma 1981;21:13-21.
4. Robinson H, Monafo WW, Saver SM, Gallagher NI. The role of erythropoietin in the anemia of thermal injury. Ann Surg 1973;178:565-572
5. Sanders R, Garcia J, Sheldon GF, Schooley J, Fuchs R, Carpenter G. Erythropoietin elevation in anemia of thermal injury. Surg Forum 1976;27:71-72
6. Sheldon GF, Sanders R, Fuchs R, Garcia J, Schooley J. Metabolism, oxygen transport, and erythropoietin synthesis in the anemia of thermal injury. Am J Surg 1978;135:406-411
7. Vasko SD, Burdge JJ, Ruberg RL, Verghese AS. Evaluation of erythropoietin levels in the anemia of thermal injury. J Burn Care Rehabil 1991;12:437-441
8. Wallner S, Vautrin R, Katz J, Murphy J. The anemia of thermal injury: partial characterization of an erythroid inhibitory substance. J Trauma 1987;27:639-645
9. Wallner SF, Vautrin R. The anemia of thermal injury: mechanism of inhibition of erythropoiesis. Proc Soc Exp Biol Med 1986;181:144-150
10. Moore FD, Peacock WC, Blakely E, Cope O. The anemia of thermal burns. Ann Surg 1946;124:811-839
11. Birdsell DC, Birch JR. Anemia following thermal burns: a survey of 109 children. Can J Surg 1971;14:345-350
12. Loebl EC, Marvin JA, Curreri W, Baxter CR. Erythrocyte survival following thermal injury. J Surg Res 1974;16: 96-101.
13. Kimber RJ, Lander H. The effect of heat on human red cell morphology, fragility, and subsequent survival in vivo. J Lab Clin Med 1964;64:922-933
14. Walsh TS, Saleh EE, Lee RJ, McClelland DB. The prevalence and characteristics of anaemia at discharge home after intensive care. Intensive Care Med 2006;32:1206-1213
15. Bateman AP, McArdle F, Walsh TS. Time course of anemia during six months follow up following intensive care discharge and factors associated with impaired recovery of erythropoiesis. Crit Care Med 2009;37:1906-1912
16. Moran KT, O'Reilly TJ, Furman W, Munster AM. A new algorithm for calculation of blood loss in excisional burn surgery. Am Surg 1988;54:207-208
17. Cartotto R, Musgrave MA, Beveridge M, Fish J, Gomez M. Minimizing blood loss in burn surgery. J Trauma 2000;49: 1034-1039
18. Budny PG, Regan PJ, Roberts AH. The estimation of blood loss during burns surgery. Burns 1993;19:134-137
19. Brown RA, Grobbelaar AO, Barker S, Rode H. A formula to calculate blood cross-match requirements for early burn surgery in children. Burns 1995;21:371-373
20. Drew PJ, Ciampolini J, Dickson WA. Blood crossmatching for burn surgery: potential for reduced wastage using a modified dye formula. Burns 1999;25:651-654
21. Dye DJ. Requirements for cross-matched blood in burns surgery. Burns 1993;19:524-528
22. Janezic T, Prezelj B, Brcic A, Arnez Z, Zaletelj-Kragelj L. Intraoperative blood loss after tangential excision of burn wounds treated by subeschar infiltration of epinephrine. Scand J Plast Reconstr Surg Hand Surg 1997;31:245-250
23. Rosenberg JL, Zawacki BE. Reduction of blood loss using tourniquets and 'compression' dressings in excising limb burns. J Trauma 1986;26:47-50.
24. Hart DW, Wolf SE, Beauford RB, Lal SO, Chinkes DL, Herndon DN. Determinants of blood loss during primary burn excision. Surgery 2001;130:396-402.
25. Yogore MG III, Boral L, Kowal-Vern A, Patel H, Brown S, Latenser BA. Use of blood bank services in a burn unit. J Burn Care Res 2006;27:835-841
26. Criswell KK, Gamelli RL. Establishing transfusion needs in burn patients. Am J Surg 2005;189:324-326
27. Palmieri TL, Caruso DM, Foster KN, et al. Effect of blood transfusion on outcome after major burn injury: a multicenter study. Crit Care Med 2006;34:1602-1607
28. Corwin HL, Gettinger A, Pearl RG, et al. The CRIT study: Anemia and blood transfusion in the critically ill- current clinical practice in the United States. Crit Care Med 2004; 32:39-52.
29. Vincent JL, Baron JF, Reinhart K, et al. Anemia and blood transfusion in critically ill patients. JAMA 2002;288: 1499-1507
30. von Ahsen N, Muller C, Serke S, Frei U, Eckardt KU. Important role of nondiagnostic blood loss and blunted erythropoietic response in the anemia of medical intensive care patients. Crit Care Med 1999;27:2630-2639
31. Corwin HL, Krantz SB. Anemia of the critically ill: "acute" anemia of chronic disease. Crit Care Med 2000;28:3098-3099
32. Walsh TS, Saleh EE. Anaemia during critical illness. Br J Anaesth 2006;97:278-291
33. Dale JC, Pruett SK. Phlebotomy-a minimalist approach. Mayo Clin Proc 1993;68:249-255
34. Sanchez-Giron F, Alvarez-Mora F. Reduction of blood loss from laboratory testing in hospitalized adult patients using small-volume (pediatric) tubes. Arch Pathol Lab Med 2008; 132:1916-1919.
35. Smoller BR, Kruskall MS, Horowitz GL. Reducing adult phlebotomy blood loss with the use of pediatric-sized blood collection tubes. Am J Clin Pathol 1989;91:701-703
36. Fowler RA, Berenson M. Blood conservation in the intensive care unit. Crit Care Med 2003;31:S715-20.
37. Silver MJ, Li YH, Gragg LA, Jubran F, Stoller JK. Reduction of blood loss from diagnostic sampling in critically ill patients using a blood-conserving arterial line system. Chest 1993; 104:1711-1715
38. Rodriguez RM, Corwin HL, Gettinger A, Corwin MJ, Gubler D, Pearl RG. Nutritional deficiencies and blunted erythropoietin response as causes of the anemia of critical illness. J Crit Care 2001;16:36-41.
39. Wallner SF, Warren GH. The haematopoietic response to burning: an autopsy study. Burns Incl Therm Inj 1985;12: 22-27
40. Wallner S, Vautrin R, Murphy J, Anderson S, Peterson V. The haematopoietic response to burning: studies in an animal model. Burns Incl Therm Inj 1984;10:236-251
41. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005;352:1011-1023
42. Finnerty CC, Herndon DN, Przkora R, et al. Cytokine expression profile over time in severely burned pediatric patients. Shock 2006;26:13-19
43. Finnerty CC, Jeschke MG, Herndon DN, et al. Temporal cytokine profiles in severely burned patients: a comparison of adults and children. Mol Med 2008;14:553-560
44. Means RT, Jr., Dessypris EN, Krantz SB. Inhibition of human colony-forming-unit erythroid by tumor necrosis factor requires accessory cells. J Clin Invest 1990;86:538-541
45. Means RT Jr, Krantz SB. Inhibition of human erythroid colonyforming units by tumor necrosis factor requires beta interferon. J Clin Invest 1993;91:416-419
46. Taniguchi S, Dai CH, Price JO, Krantz SB. Interferon gamma downregulates stem cell factor and erythropoietin receptors but not insulin-like growth factor-I receptors in human erythroid colony-forming cells. Blood 1997;90: 2244-2252
47. Wang CQ, Udupa KB, Lipschitz DA. Interferon-gamma exerts its negative regulatory effect primarily on the earliest stages of murine erythroid progenitor cell development. J Cell Physiol 1995;162:134-138
48. Jongen-Lavrencic M, Peeters HR, Rozemuller H, et al. IL- 6-induced anaemia in rats: possible pathogenetic implications for anemia observed in chronic inflammations. Clin Exp Immunol 1996;103:328-334
49. Graves TA, Cioffi WG, Mason AD Jr, McManus WF, Pruitt BA Jr. Relationship of transfusion and infection in a burn population. J Trauma 1989;29:948-52; discussion 952-954
50. Palmieri TL, Greenhalgh DG. Blood transfusion in burns: what do we do? J Burn Care Rehabil 2004;25:71-75
51. Goodnough LT. Risks of blood transfusion. Crit Care Med 2003;31:S678-86.
52. Alter HJ, Klein HG. The hazards of blood transfusion in historical perspective. Blood 2008;112:2617-2626
53. Gianotti L, Pyles T, Alexander JW, Babcock GF, Carey MA. Impact of blood transfusion and burn injury on microbial translocation and bacterial survival. Transfusion 1992;32: 312-317
54. Leal-Noval SR, Rincon-Ferrari MD, Garcia-Curiel A, et al. Transfusion of blood components and postoperative infection in patients undergoing cardiac surgery. Chest 2001;119: 1461-1468
55. Torchia MG, Danzinger RG. Perioperative blood transfusion and albumin administration are independent risk factors for the development of postoperative infections after colorectal surgery. Can J Surg 2000;43:212-216
56. Bochicchio GV, Napolitano L, Joshi M, et al. Blood product transfusion and ventilator-associated pneumonia in trauma patients. Surg Infect (Larchmt) 2008;9:415-422
57. Claridge JA, Sawyer RG, Schulman AM, McLemore EC, Young JS. Blood transfusions correlate with infections in trauma patients in a dose-dependent manner. Am Surg 2002; 68:566-572
58. Croce MA, Tolley EA, Claridge JA, Fabian TC. Transfusions result in pulmonary morbidity and death after a moderate degree of injury. J Trauma 2005;59:19-23; discussion 23-24
59. Marik PE, Corwin HL. Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature. Crit Care Med 2008;36:2667-2674
60. Taylor RW, Manganaro L, O'Brien J, Trottier SJ, Parkar N, Veremakis C. Impact of allogenic packed red blood cell transfusion on nosocomial infection rates in the critically ill patient. Crit Care Med 2002;30:2249-2254
61. Taylor RW, O'Brien J, Trottier SJ, et al. Red blood cell transfusions and nosocomial infections in critically ill patients. Crit Care Med 2006;34:2302-8; quiz 2309.
62. FDA. Fatalities reported to FDA following blood collection and transfusion: annual summary of fiscal year 2008. Rockville: Center for Biologics Evaluation and Research; 2008.
63. Kleinman S, Caulfield T, Chan P, et al. Toward an understanding of transfusion-related acute lung injury: statement of a consensus panel. Transfusion 2004;44:1774-1789
64. Webert KE, Blajchman MA. Transfusion-related acute lung injury. Curr Opin Hematol 2005;12:480-487
65. Silliman CC, Fung YL, Bradley Ball J, Khan SY. Transfusionrelated acute lung injury (TRALI): current concepts and misconceptions. Blood Rev 2009;23:245-255
66. Higgins S, Fowler R, Callum J, Cartotto R. Transfusionrelated acute lung injury in patients with burns. J Burn Care Res 2007;28:56-64.
67. Silver GM, Klein MB, Herndon DN, et al. Standard operating procedures for the clinical management of patients enrolled in a prospective study of inflammation and the host response to thermal injury. J Burn Care Res 2007;28: 222-230
68. Linden JV, Wagner K, Voytovich AE, Sheehan J. Transfusion errors in New York State: an analysis of 10 years' experience. Transfusion 2000;40:1207-1213
69. Hebert PC, Van der Linden P, Biro G, Hu LQ. Physiologic aspects of anemia. Crit Care Clin 2004;20:187-212.
70. Fisher JW, Koury S, Ducey T, Mendel S. Erythropoietin production by interstitial cells of hypoxic monkey kidneys. Br J Haematol 1996;95:27-32.
71. Fried W. Erythropoietin and erythropoiesis. Exp Hematol 2009;37:1007-1015
72. Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW. Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial. N Engl J Med 1987;316:73-78
73. Singh AK, Szczech L, Tang KL, et al. Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med 2006;355:2085-2098
74. Erslev AJ, Wilson J, Caro J. Erythropoietin titers in anemic, nonuremic patients. J Lab Clin Med 1987;109:429-433
75. Rogiers P, Zhang H, Leeman M, et al. Erythropoietin response is blunted in critically ill patients. Intensive Care Med 1997;23:159-162
76. Krafte-Jacobs B, Levetown ML, Bray GL, Ruttimann UE, Pollack MM. Erythropoietin response to critical illness. Crit Care Med 1994;22:821-826
77. Hobisch-Hagen P, Wiedermann F, Mayr A, et al. Blunted erythropoietic response to anemia in multiply traumatized patients. Crit Care Med 2001;29:743-747
78. Goodnough LT, Monk TG, Andriole GL. Erythropoietin therapy. N Engl J Med 1997;336:933-938
79. Rizzo JD, Seidenfeld J, Piper M, Aronson N, Lichtin A, Littlewood TJ. Erythropoietin: a paradigm for the development of practice guidelines. Hematology Am Soc Hematol Educ Program 2001:10-30.
80. Fleming RY, Herndon DN, Vaidya S, et al. The effect of erythropoietin in normal healthy volunteers and pediatric patients with burn injuries. Surgery 1992;112:424-31; discussion 431-432
81. Still JM Jr, Belcher K, Law EJ, et al. A double-blinded prospective evaluation of recombinant human erythropoietin in acutely burned patients. J Trauma 1995;38:233-236
82. Corwin HL, Gettinger A, Fabian TC, et al. Efficacy and safety of epoetin alfa in critically ill patients. N Engl J Med 2007; 357:965-976
83. Zarychanski R, Turgeon AF, McIntyre L, Fergusson DA. Erythropoietin- receptor agonists in critically ill patients: a meta-analysis of randomized controlled trials. CMAJ 2007; 177:725-734
84. Arcasoy MO. Erythropoiesis-stimulating agents in cancer. J Clin Oncol 2008;26:3097-8; author reply 3098-3100
85. Burger D, Lei M, Geoghegan-Morphet N, Lu X, Xenocostas A, Feng Q. Erythropoietin protects cardiomyocytes from apoptosis via up-regulation of endothelial nitric oxide synthase. Cardiovasc Res 2006;72:51-59
86. Fantacci M, Bianciardi P, Caretti A, et al. Carbamylated erythropoietin ameliorates the metabolic stress induced in vivo by severe chronic hypoxia. Proc Natl Acad Sci U S A 2006;103:17531-17536
87. Liu X, Xie W, Liu P, et al. Mechanism of the cardioprotection of rhEPO pretreatment on suppressing the inflammatory response in ischemia-reperfusion. Life Sci 2006;78:2255-2264
88. Mori S, Sawada T, Okada T, Kubota K. Erythropoietin and its derivative protect the intestine from severe ischemia/ reperfusion injury in the rat. Surgery 2008;143:556-565
89. Warden GD, Saffle JR, Kravitz M. A two-stage technique for excision and grafting of burn wounds. J Trauma 1982;22: 98-103.
90. Marano MA, O'Sullivan G, Madden M, Finkelstein J, Goodwin CW. Tourniquet technique for reduced blood loss and wound assessment during excisions of burn wounds of the extremity. Surg Gynecol Obstet 1990;171:249-250
91. Smoot EC III. Modified use of extremity tourniquets for burn wound debridement. J Burn Care Rehabil 1996;17: 334-337
92. O'Mara MS, Goel A, Recio P, et al. The use of tourniquets in the excision of unexsanguinated extremity burn wounds. Burns 2002;28:684-687
93. Robertson RD, Bond P, Wallace B, Shewmake K, Cone J. The tumescent technique to significantly reduce blood loss during burn surgery. Burns 2001;27:835-838
94. Kahalley L, Dimick AR, Gillespie RW. Methods to diminish intraoperative blood loss. J Burn Care Rehabil 1991;12: 160-161
95. Sheridan RL, Szyfelbein SK. Staged high-dose epinephrine clysis is safe and effective in extensive tangential burn excisions in children. Burns 1999;25:745-748
96. Cartotto R, Kadikar N, Musgrave MA, Gomez M, Cooper AB. What are the acute cardiovascular effects of subcutaneous and topical epinephrine for hemostasis during burn surgery? J Burn Care Rehabil 2003;24:297-305.
97. Missavage AE, Bush RL, Kien ND, Reilly DA. The effect of clysed and topical epinephrine on intraoperative catecholamine levels. J Trauma 1998;45:1074-1078
98. Papp AA, Uusaro AV, Ruokonen ET. The effects of topical epinephrine on haemodynamics and markers of tissue perfusion in burned and non-burned patients requiring skin grafting. Burns 2009;35:832-839
99. Barret JP, Dziewulski P, Wolf SE, Desai MH, Nichols RJ II, Herndon DN. Effect of topical and subcutaneous epinephrine in combination with topical thrombin in blood loss during immediate near-total burn wound excision in pediatric burned patients. Burns 1999;25:509-513
100. Sheridan RL, Szyfelbein SK. Trends in blood conservation in burn care. Burns 2001;27:272-276
101. Gomez M, Logsetty S, Fish JS. Reduced blood loss during burn surgery. J Burn Care Rehabil 2001;22:111-117
102. Hebert PC, Wells G, Blajchman MA, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 1999;340:409-417
103. Sittig KM, Deitch EA. Blood transfusions: for the thermally injured or for the doctor? J Trauma 1994;36:369-372
104. Mann R, Heimbach DM, Engrav LH, Foy H. Changes in transfusion practices in burn patients. J Trauma 1994;37: 220-222
105. Kwan P, Gomez M, Cartotto R. Safe and successful restriction of transfusion in burn patients. J Burn Care Res 2006; 27:826-834
106. Palmieri TL, Lee T, O'Mara MS, Greenhalgh DG. Effects of a restrictive blood transfusion policy on outcomes in children with burn injury. J Burn Care Res 2007;28:65-70.
107. Corwin HL, Carson JL. Blood transfusion-when is more really less? N Engl J Med 2007;356:1667-1669
108. Djurickovic S, Snelling CF, Boyle JC. Tourniquet and subcutaneous epinephrine reduce blood loss during burn excision and immediate autografting. J Burn Care Rehabil 2001; 22:1-5.