Cardiac and plasma lipid profiles in response to acute hypoxia in neonatal and young adult rats

Lipids in Health and Disease

Volumn 9, Issue 1, 2010, Pages

  Bruder, Eric D ^a   Raff, Hershel ^a,b  

^a ST LUKE S MEDICAL CENTER   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLCARNITINE; CARNITINE DERIVATIVE; CHOLESTEROL; DIACYLGLYCEROL DERIVATIVE; DIACYLGLYERCOL; LINOLEYLCARNITINE; LONG CHAIN FATTY ACID; LYSOPHOSPHATIDYLCHOLINE; OLEYLCARNITINE; OXYGEN; PALMITOYLCARNITINE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; PROPIONYLCARNITINE; STEAROYLCARNITINE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; CARNITINE; DRUG DERIVATIVE; FATTY ACID; LIPID;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FATTY ACID ANALYSIS; FEMALE; HEART FUNCTION; HEART TISSUE; HYPOXIA; LIPID BLOOD LEVEL; MALE; METABOLITE; NEWBORN; NONHUMAN; OXYGEN CONCENTRATION; RAT; SURVIVAL RATE; YOUNG ADULT; ANIMAL; ANOXIA; BIOLOGICAL MODEL; BLOOD; CHEMISTRY; FAT INTAKE; HEART MUSCLE; METABOLISM; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; ANOXIA; CARNITINE; DIETARY FATS; FATTY ACIDS; FEMALE; LIPIDS; MALE; MODELS, BIOLOGICAL; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 77649293806     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-9-3     Document Type: Article

References (28)

1. Frankel L, Stevenson DK: Metabolic emergencies of the newborn: hypoxemia and hypoglycemia. Compr Ther 1987, 13:14-19.
2. Friedman AH, Fahey JT: The transition from fetal to neonatal circulation: normal responses and implications for infants with heart disease. Semin Perinatol 1993, 17:106-121.
3. Knight DB: The treatment of patent ductus arteriosus in preterm infants. A review and overview of randomized trials. Semin Neonatol 2001, 6:63-73.
4. Yu VY, Knight DB, Obeyesekere HI, Mitvalsky J: The management of patent ductus arteriosus in very low birthweight infants. J Singapore Paediatr Soc 1983, 25:159-166.
5. Bruder ED, Taylor JK, Kamer KJ, Raff H: Development of the ACTH and corticosterone response to acute hypoxia in the neonatal rat. Am J Physiol Regul Integr Comp Physiol 2008, 295:R1195-R1203.
6. Kjekshus JK, Ellekjaer E, Rinde P: The effect of free fatty acids on oxygen consumption in man: the free fatty acid hypothesis. Scand J Clin Lab Invest 1980, 40:63-70.
7. Pinotti MF, Silva MD, Sugizaki MM, Diniz YS, Sant'ana LS, Aragon FF, Padovani CR, Novelli EL, Cicogna AC: Effect of unsaturated fatty acids on myocardial performance, metabolism and morphology. Braz J Med Biol Res 2006, 39:305-312.
8. Simopoulos AP: The omega-6/omega-3 fatty acid ratio, genetic variation, and cardiovascular disease. Asia Pac J Clin Nutr 2008, 17(Suppl 1):131-134.
9. Lee van der KA, Vork MM, De Vries JE, Willemsen PH, Glatz JF, Reneman RS, van der V, van Bilsen M: Long-chain fatty acid-induced changes in gene expression in neonatal cardiac myocytes. J Lipid Res 2000, 41:41-47.
10. Vusse Van der GJ, Glatz JF, Stam HC, Reneman RS: Fatty acid homeostasis in the normoxic and ischemic heart. Physiol Rev 1992, 72:881-940.
11. Vusse Van der GJ, Van Bilsen M, Glatz JF: Cardiac fatty acid uptake and transport in health and disease. Cardiovasc Res 2000, 45:279-293.
12. Osmundsen H, Hovik R: Beta-oxidation of polyunsaturated fatty acids. Biochem Soc Trans 1988, 16:420-422.
13. Boudina S, Sena S, O'Neill BT, Tathireddy P, Young ME, Abel ED: Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity. Circulation 2005, 112:2686-2695.
14. Corr PB, Yamada KA: Selected metabolic alterations in the ischemic heart and their contributions to arrhythmogenesis. Herz 1995, 20:156-168.
15. Kim D, Duff RA: Regulation of K+ channels in cardiac myocytes by free fatty acids. Circ Res 1990, 67:1040-1046.
16. Stanley WC, Chandler MP: Energy metabolism in the normal and failing heart: potential for therapeutic interventions. Heart Fail Rev 2002, 7:115-130.
17. Bruder ED, Lee PC, Raff H: Metabolomic analysis of adrenal lipids during hypoxia in the neonatal rat: implications in steroidogenesis. Am J Physiol Endocrinol Metab 2004, 286:E697-E703.
18. Makinde AO, Kantor PF, Lopaschuk GD: Maturation of fatty acid and carbohydrate metabolism in the newborn heart. Mol Cell Biochem 1998, 188:49-56.
19. Vance JE, Steenbergen R: Metabolism and functions of phosphatidylserine. Prog Lipid Res 2005, 44:207-234.
20. Ford DA, Hale CC: Plasmalogen and anionic phospholipid dependence of the cardiac sarcolemmal sodium-calcium exchanger. FEBS Lett 1996, 394:99-102.
21. Yamada KA, Kanter EM, Newatia A: Long-chain acylcarnitine induces Ca2+ efflux from the sarcoplasmic reticulum. J Cardiovasc Pharmacol 2000, 36:14-21.
22. Yamada KA, McHowat J, Yan GX, Donahue K, Peirick J, Kleber AG, Corr PB: Cellular uncoupling induced by accumulation of long-chain acylcarnitine during ischemia. Circ Res 1994, 74:83-95.
23. Kjekshus JK, Mjos OD: Effect of free fatty acids on myocardial function and metabolism in the ischemic dog heart. J Clin Invest 1972, 51:1767-1776.
24. Wu J, McHowat J, Saffitz JE, Yamada KA, Corr PB: Inhibition of gap junctional conductance by long-chain acylcarnitines and their preferential accumulation in junctional sarcolemma during hypoxia. Circ Res 1993, 72:879-889.
25. Stanley WC, Lopaschuk GD, Hall JL, McCormack JG: Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions. Cardiovasc Res 1997, 33:243-257.
26. Ford DA, Han X, Horner CC, Gross RW: Accumulation of unsaturated acylcarnitine molecular species during acute myocardial ischemia: metabolic compartmentalization of products of fatty acyl chain elongation in the acylcarnitine pool. Biochemistry 1996, 35:7903-7909.
27. Kang JX, Leaf A: Evidence that free polyunsaturated fatty acids modify Na+ channels by directly binding to the channel proteins. Proc Natl Acad Sci USA 1996, 93:3542-3546.
28. Burton KP, Buja LM, Sen A, Willerson JT, Chien KR: Accumulation of arachidonate in triacylglycerols and unesterified fatty acids during ischemia and reflow in the isolated rat heart. Correlation with the loss of contractile function and the development of calcium overload. Am J Pathol 1986, 124:238-245.