Treatment effects of therapeutic cholinesterase inhibitors on visuospatial processing in Alzheimer's disease: A longitudinal functional MRI study

Dementia and Geriatric Cognitive Disorders

Volumn 29, Issue 2, 2010, Pages 176-188

  Thiyagesh, Subha N ^a   Farrow, Tom F D ^a   Parks, Randolph W ^a   Accosta Mesa, Hector ^a   Hunter, Michael D ^a   Young, Claire ^a   Wilkinson, Iain D ^a   Woodruff, Peter W R ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Acetyl cholinesterase inhibitors; Alzheimer's disease; FMRI; Normal ageing; Visuospatial perception

Indexed keywords

CHOLINESTERASE INHIBITOR; DONEPEZIL;

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DEPTH PERCEPTION; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; LONGITUDINAL STUDY; MALE; PRIORITY JOURNAL; TREATMENT OUTCOME; VISION;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CEREBRAL CORTEX; CHOLINESTERASE INHIBITORS; DATA INTERPRETATION, STATISTICAL; DISEASE PROGRESSION; FEMALE; FIXATION, OCULAR; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MALE; MOTION PERCEPTION; MOTOR CORTEX; NEUROPSYCHOLOGICAL TESTS; OXYGEN; PARIETAL LOBE; PHOTIC STIMULATION; SPACE PERCEPTION; TREATMENT OUTCOME; VISUAL PERCEPTION;

EID: 77649289415     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000275674     Document Type: Article

References (66)

1. Beelke M, Sannita WG: Cholinergic function and dysfunction in the visual system. Methods Find Exp Clin Pharmacol 2002; 24: 113-117. (Pubitemid 35462373)
2. Nobili L, Sannita WG: Cholinergic modulation, visual function and Alzheimer's dementia. Vision Res 1997; 37: 3559-3571. (Pubitemid 27491635)
3. Bentley P, Driver J, Dolan RJ: Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health. Brain 2008; 131: 409-424. (Pubitemid 351197610)
4. Furey ML, Pietrini P, Haxby JV: Cholinergic enhancement and increased selectivity of perceptual processing during working memory. Science 2000; 290: 2315-2319. (Pubitemid 32041576)
5. Schliebs R, Arendt T: The significance of the cholinergic system in the brain during aging and in Alzheimer's disease. J Neural Transm 2006; 113: 1625-1644. (Pubitemid 44657659)
6. Lawrence AD, Sahakian BJ: Alzheimer disease, attention, and the cholinergic system. Alzheimer Dis Assoc Disord 1995; 9: 43-49.
7. Mendez MF, Cherrier MM, Meadows RS: Depth perception in Alzheimer's disease. Percept Mot Skills 1996; 83: 987-995. (Pubitemid 126728849)
8. Dunne TE, Neargarder SA, Cipolloni PB, Cronin-Golomb A: Visual contrast enhances food and liquid intake in advanced Alzheimer's disease. Clin Nutr 2004; 23: 533-538. (Pubitemid 39107032)
9. Rizzo M, Anderson SW, Dawson J, Nawrot M: Vision and cognition in Alzheimer's disease. Neuropsychologia 2000; 38: 1157-1169. (Pubitemid 30323666)
10. Thiyagesh SN, Farrow TFD, Parks RW, Accosta-Mesa H, Young C, Wilkinson ID, Hunter MD, Woodruff PWR: The neural basis of visuospatial perception in Alzheimer's disease and healthy elderly comparison subjects: an fMRI study. Psychiatry Res Neuroimaging 2009; 172: 109-116.
11. Jackson GR, Owsley C: Visual dysfunction, neurodegenerative diseases, and aging. Neurol Clin N Am 2003; 21: 709-728. (Pubitemid 36754063)
12. Woodruff PW, Benson RR, Bandettini PA, Kwong KK, Howard RJ, Talavage T, Belliveau J, Rosen BR: Modulation of auditory and visual cortex by selective attention is modalitydependent. Neuroreport 1996; 7: 1909-1913. (Pubitemid 26348190)
13. Ciaramitaro VM, Buracas GT, Boynton GM: Spatial and cross-modal attention alter responses to unattended sensory information in early visual and auditory human cortex. J Neurophysiol 2007; 98: 2399-2413.
14. Ashburner J, Friston KJ: Voxel-based morphometry - the methods. Neuroimage 2000; 11: 805. (Pubitemid 30437668)
15. Takeda A, Loveman E, Clegg A, Kirby J, Picot J, Payne E, Green C: A systematic review of the clinical effectiveness of donepezil, rivastigmine and galantamine on cognition, quality of life and adverse events in Alzheimer's disease. Int J Geriatr Psychiatry 2006; 21: 17-28. (Pubitemid 43141491)
16. Birks J: Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst Rev 2006; 25:CD005593. (Pubitemid 46841366)
17. Benjamin B, Burns A: Donepezil for Alzheimer's disease. Exp Rev Neurother 2007; 7: 1243-1249. (Pubitemid 350012716)
18. Takada-Takatori Y, Kume T, Sugimoto M, Katsuki H, Sugimoto H, Akaike A: Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade. Neuropharmacology 2006; 51: 474-486. (Pubitemid 44215955)
19. Akaike A, Takada-Takatori Y, Kume T, Izumi Y: Mechanisms of Neuroprotective Effects of Nicotine and Acetylcholinesterase Inhibitors: Role of α 4 and α 7 Receptors in Neuroprotection. J Mol Neurosci 2010;40: 211-216.
20. Akinori A, Hiroshi K, Toshiaki K, Yuki TT: Neuroprotective action of donepezil mediated by neuronal nicotinic receptors. Psychogeriatrics 2006; 6:S47-S56.
21. Prvulovic D, Hubl D, Sack AT, Melillo L, Maurer K, Frolich L, Lanfermann H, Zanella FE, Goebel R, Linden DEJ, Dierks T: Functional imaging of visuospatial processing in Alzheimer's disease. NeuroImage 2002; 17: 1403-1414. (Pubitemid 35333860)
22. Leinsinger G, Born C, Meindl T, Bokde ALW, Britsch S, Lopez-Bayo P, Teipel SJ, Moller HJ, Hampel H, Reiser MF: Age-dependent differences in human brain activity using a face- and location-matching task: an fMRI study. Dement Geriatr Cogn Disord 2007; 24: 235-246. (Pubitemid 47482069)
23. Nishida Y, Hayashi O, Iwami T, Kimura M, Kani K, Ito R, Shiino A, Suzuki M: Stereopsis- processing regions in the human parietooccipital cortex. Neuroreport 2001; 12: 2259-2263. (Pubitemid 32646284)
24. Backus BT, Fleet DJ, Parker AJ, Heeger DJ: Human cortical activity correlates with stereoscopic depth perception. J Neurophysiol 2001; 86: 2054-2068.
25. Tsao DY, Vanduffel W, Sasaki Y, Fize D, Knutsen TA, Mandeville JB, Wald LL, Dale AM, Rosen BR, Van Essen DC, Livingstone MS, Orban GA, Tootell RB: Stereopsis activates V3A and caudal intraparietal areas in macaques and humans. Neuron 2003; 39: 555-568. (Pubitemid 36937054)
26. Zeki S, Watson JD, Lueck CJ, Friston KJ, Kennard C, Frackowiak RS: A direct demonstration of functional specialization in human visual cortex. J Neurosci 1991; 11: 641-649.
27. Cheng K, Fujita H, Kanno I, Miura S, Tanaka K: Human cortical regions activated by wide-field visual motion: an H2(15)O PET study. J Neurophysiol 1995; 74: 413-427.
28. Lamm C, Windischberger C, Leodolter U, Moser E, Bauer H: Evidence for premotor cortex activity during dynamic visuospatial imagery from single-trial functional magnetic resonance imaging and event-related slow cortical potentials. Neuroimage 2001; 14: 268-283. (Pubitemid 32709543)
29. Johnson SC, Saykin AJ, Baxter AC, Flashman LA, Santulli RB, McAllister TW, Manmourian AC: The relationship between fMRI activation and cerebral atrophy: comparison of normal aging and Alzheimer disease. Neuroimage 2000; 11: 179-187.
30. Kircher TTJ, Erb M, Grodd W, Leube DT: Cortical activation during cholinesteraseinhibitor treatment in Alzheimer disease: preliminary findings from a pharmaco-fMRI study. Am J Geriatr Psychiatry 2005; 13: 1006-1013. (Pubitemid 46638668)
31. Shanks MF, McGeown WJ, Forbes-McKay KE, Waiter GD, Ries M, Venneri A: Regional brain activity after prolonged cholinergic enhancement in early Alzheimer's disease. Magn Reson Imaging 2007; 25: 848. (Pubitemid 47081360)
32. Goekoop R, Rombouts SARB, Jonker C, Hibbel A, Knol DL, Truyen L, Barkhof F, Scheltens P: Challenging the cholinergic system in mild cognitive impairment: a pharmacological fMRI study. Neuroimage 2004; 23: 1450. (Pubitemid 40260368)
33. Goekoop R, Scheltens P, Barkhof F, Rombouts SARB: Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation - a pharmacological fMRI study. Brain 2006; 129: 141-157. (Pubitemid 43063766)
34. Buckner RL, Goodman J, Burock M, Rotte M, Koutstaal W, Schacter D, Rosen B, Dale AM: Functional-anatomic correlates of object priming in humans revealed by rapid presentation event-related fMRI. Neuron 1998; 20: 285. (Pubitemid 28125072)
35. Van Turennout M, Bielamowicz L, Martin A: Modulation of neural activity during object naming: effects of time and practice. Cereb Cortex 2003; 13: 381-391. (Pubitemid 36373684)
36. Blondin F, Lepage M: Decrease and increase in brain activity during visual perceptual priming: an fMRI study on similar but perceptually different complex visual scenes. Neuropsychologia 2005; 43: 1887. (Pubitemid 41317405)
37. Folstein MF, Folstein SE, McHugh PR: Minimental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189.
38. Rosen WG, Mohs RC, Davis KL: A new rating scale for Alzheimer's disease. Am J Psychiatry 1984; 141: 1356-1364.
39. Crockett D, Tuokko H, Koch W, Parks R: The assessment of everyday functioning using the present functioning questionnaire and the functional rating scales in elderly samples. Clin Gerontol 1989; 8: 3-25.
40. Good CD, Johnsrude IS, Ashburner J, Henson RNA, Friston KJ, Frackowiak RSJ: A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 2001; 14: 21. (Pubitemid 32552740)
41. Farrow TFD, Thiyagesh SN, Wilkinson ID, Parks RW, Ingram L, Woodruff PWR: Fronto- temporal-lobe atrophy in early-stage Alzheimer's disease identified using an improved detection methodology. Psychiatry Res Neuroimaging 2007; 155: 11-19. (Pubitemid 46578288)
42. Talairach J, Tournoux P: A Co-Planar Stereotactic Atlas of the Human Brain. Stuttgart, Thieme Medical Publishers, 1988.
43. Le TH, Pardo JV, Hu X: 4 T-fMRI Study of nonspatial shifting of selective attention: cerebellar and parietal contributions. J Neurophysiol 1998; 79: 1535-1548. (Pubitemid 28125384)
44. Zakzanis KK, Graham SJ, Campbell Z: A meta-analysis of structural and functional brain imaging in dementia of the Alzheimer's Type: a neuroimaging profile. Neuropsychol Rev 2003; 13: 1-18. (Pubitemid 38101918)
45. Lundstrom BN, Petersson KM, Andersson J, Johansson M, Fransson P, Ingvar M: Isolating the retrieval of imagined pictures during episodic memory: activation of the left precuneus and left prefrontal cortex. Neuroimage 2003; 20: 1934. (Pubitemid 37543612)
46. Lundstrom BN, Ingvar M, Petersson KM: The role of precuneus and left inferior frontal cortex during source memory episodic retrieval. Neuroimage 2005; 27: 824. (Pubitemid 41317252)
47. Suchan B, Yágüez L, Wunderlich G, Canavan AGM, Herzog H, Tellmann L, Hömberg V, Seitz RJ: Hemispheric dissociation of visualpattern processing and visual rotation. Behav Brain Res 2002; 136: 533. (Pubitemid 35333269)
48. Cavanna AE, Trimble MR: The precuneus: a review of its functional anatomy and behavioural correlates. Brain 2006; 129: 564-583.
49. Corbetta M, Shulman GL: Control of goaldirected and stimuls-driven attention in the brain. Nat Rev Neurosci 2002; 3: 201-215. (Pubitemid 135706590)
50. Kastner S, Ungerleider LG: The neural basis of biased competition in human visual cortex. Neuropsychologia 2001; 39: 1263. (Pubitemid 32826271)
51. Pignatti R, Rabuffetti M, Imbornone E, Mantovani F, Alberoni M, Farina E, Canal N: Specific impairments of selective attention in mild Alzheimer's disease. J Clin Exp Neuropsychology2005; 27: 436. (Pubitemid 40524506)
52. Posner MI, Petersen SE: The attention system of the human brain. Annu Rev Neurosci 1990; 13: 25-42.
53. Belmonte MK, Yurgelun-Todd DA: Functional anatomy of impaired selective attention and compensatory processing in autism. Cogn Brain Res 2003; 17: 651.
54. Paradis AL, Cornilleau-Peres V, Droulez J, Van de Moortele PF, Lobel E, Berthoz A, Le Bihan D, Poline JB: Visual perception of motion and 3-D structure from motion: an fMRI study. Cereb Cortex 2000; 10: 772-783. (Pubitemid 30602902)
55. Previc FH, Liotti M, Blakemore C, Beer J, Fox P: Functional imaging of brain areas involved in the processing of coherent and incoherent wide field-of-view visual motion. Exp Brain Res 2000; 131: 393-405. (Pubitemid 30198047)
56. Caplan JB, Luks TL, Simpson GV, Glaholt M, McIntosh AR: Parallel networks operating across attentional deployment and motion processing: A multi-seed partial least squares fMRI study. Neuroimage 2006; 29: 1192. (Pubitemid 43184182)
57. Shulman GL, Ollinger JM, Akbudak E, Conturo TE, Snyder AZ, Petersen SE, Corbetta M: Areas involved in encoding and applying directional expectations to moving objects. J Neurosci 1999; 19: 9480-9496. (Pubitemid 30228100)
58. Luks TL, Simpson GV: Preparatory deployment of attention to motion activates higherorder motion-processing brain regions. Neuroimage 2004; 22: 1515.
59. Chouinard PA, Paus T: The primary motor and premotor areas of the human cerebral cortex. Neuroscientist 2006; 12: 143-152.
60. Lee ACH, Bandelow S, Schwarzbauer C, Henson RNA, Graham KS: Perirhinal cortex activity during visual object discrimination: an event-related fMRI study. Neuroimage 2006; 33: 362. (Pubitemid 44397591)
61. Piekema C, Kessels RPC, Mars RB, Petersson KM, Fernandez G: The right hippocampus participates in short-term memory maintenance of object-location associations. Neuroimage 2006; 33: 374. (Pubitemid 44397594)
62. Venneri A, Shanks MF, Staff RT, Pestell S, Forbes KE, Gemmell H, Murray AD: Cerebral blood flow and cognitive responses to rivastigmine treatment in Alzheimer's disease. Neuroreport 2002; 13: 83-87. (Pubitemid 34102031)
63. Balducci C, Nurra M, Pietropoli A, Samanin R, Carli M: reversal of visual attention dysfunction after AMPA lesions of the nucleus basalis magnocellularis (NBM) by the cholinesterase inhibitor donepezil and by a 5-HT1A receptor antagonist WAY 100635. Psychopharmacology 2003; 167: 28-36. (Pubitemid 36535289)
64. Mega MS, Dinov ID, Porter V, Chow G, Reback E, Davoodi P, O'Connor SM, Carter MF, Amezcua H, Cummings JL: Metabolic patterns associated with the clinical response to galantamine therapy: a fludeoxyglucose F 18 positron emission tomographic study. Arch Neurol 2005; 62: 721-728. (Pubitemid 40656086)
65. Shimizu S, Hanyu H, Iwamoto T, Koizumi K, Abe K: SPECT follow-up study of cerebral blood flow changes during donepezil therapy in patients with Alzheimer's disease. J Neuroimaging 2006; 16: 16-23. (Pubitemid 43238060)
66. Honey GD, Bullmore ET, Sharma T: Prolonged reaction time to a verbal working memory task predicts increased power of posterior parietal cortical activation. Neuroimage 2000; 12: 495.