Simple, chemoselective, and diastereoselective Reformatsky-type synthesis of α-bromo-α-fluoro-β-lactams

Tetrahedron Letters

Volumn 51, Issue 15, 2010, Pages 2000-2003

  Tarui, Atsushi ^a   Kawashima, Naoto ^a   Sato, Kazuyuki ^a   Omote, Masaaki ^a   Miwa, Yoshihisa ^b   Minami, Hideki ^b   Ando, Akira ^a  

^a SETSUNAN UNIVERSITY   (Japan)

^b HIROSHIMA INTERNATIONAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AZIRIDINE DERIVATIVE; BETA LACTAM DERIVATIVE;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; DIASTEREOISOMER; DRUG SYNTHESIS; REFORMATSKY REACTION; STEREOCHEMISTRY;

EID: 77649273937     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.02.023     Document Type: Article

References (19)

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16. 2, AcOEt/hexane = 1:9) to give the corresponding α-bromo-α-fluoro-β-lactam (6a, 254.5 mg, 76%).
17. -1: 1787, 1204.
18. CCDC 753299 contains the supplementary crystallographic data for this Letter. These data can be obtained free of charge from the Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif.
19. The other isomer of 6a; anti configuration for H-F.