Skin deep: What can the study of dermal fibroblasts teach us about dilated cardiomyopathy?

Journal of Molecular and Cellular Cardiology

Volumn 48, Issue 4, 2010, Pages 576-578

  Jensen, Brian C ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EMERIN; LAMIN A; LAMIN C; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

CELL NUCLEUS MEMBRANE; CELL SPREADING; CONGESTIVE CARDIOMYOPATHY; EDITORIAL; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENE MUTATION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE CONTRACTILITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN FIBROBLAST;

ANIMALS; CARDIOMYOPATHY, DILATED; CELL DIFFERENTIATION; CYTOSKELETON; FIBROBLASTS; HUMANS; MICE; MODELS, BIOLOGICAL; MUTATION; MYOCARDIUM; MYOCYTES, CARDIAC; SKIN;

EID: 77649270536     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2009.11.021     Document Type: Editorial

References (23)

1. Jweied E., deTombe P., and Buttrick P.M. The use of human cardiac tissue in biophysical research: the risks of translation. J. Mol. Cell. Cardiol. 42 4 (2007 Apr) 722-726
2. Burkett E.L., and Hershberger R.E. Clinical and genetic issues in familial dilated cardiomyopathy. J. Am. Coll. Cardiol. 45 7 (2005 Apr 5) 969-981
3. Taylor D.O., Stehlik J., Edwards L.B., Aurora P., Christie J.D., Dobbels F., et al. Registry of the international society for heart and lung transplantation: twenty-sixth official adult heart transplant report-2009. J. Heart. Lung. Transplant 28 10 (2009 Oct) 1007-1022
4. Karkkainen S., and Peuhkurinen K. Genetics of dilated cardiomyopathy. Ann. Med. 39 2 (2007) 91-107
5. Chang A.N., and Potter J.D. Sarcomeric protein mutations in dilated cardiomyopathy. Heart Fail Rev. 10 3 (2005 Sep) 225-235
6. Fatkin D., MacRae C., Sasaki T., Wolff M.R., Porcu M., Frenneaux M., et al. Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease. N. Engl. J. Med. 341 23 (1999 Dec 2) 1715-1724
7. Worman H.J., Fong L.G., Muchir A., and Young S.G. Laminopathies and the long strange trip from basic cell biology to therapy. J. Clin. Invest. 119 7 (2009 Jul) 1825-1836
8. Malhotra R., and Mason P.K. Lamin A/C deficiency as a cause of familial dilated cardiomyopathy. Curr. Opin. Cardiol. 24 3 (2009 May) 203-208
9. Mestroni L., and Taylor M.R. Lamin A/C gene and the heart: how genetics may impact clinical care. J. Am. Coll. Cardiol. 52 15 (2008 Oct 7) 1261-1262
10. Schirmer E.C., and Foisner R. Proteins that associate with lamins: many faces, many functions. Exp. Cell. Res. 313 10 (2007 Jun 10) 2167-2179
11. Muchir A., Shan J., Bonne G., Lehnart S.E., and Worman H.J. Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins. Hum. Mol. Genet. 18 2 (2009 Jan 15) 241-247
12. Nikolova V., Leimena C., McMahon A.C., Tan J.C., Chandar S., Jogia D., et al. Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice. J. Clin. Invest. 113 3 (2004 Feb) 357-369
13. Muchir A., Medioni J., Laluc M., Massart C., Arimura T., van der Kooi A.J., et al. Nuclear envelope alterations in fibroblasts from patients with muscular dystrophy, cardiomyopathy, and partial lipodystrophy carrying lamin A/C gene mutations. Muscle Nerve 30 4 (2004 Oct) 444-450
14. Emerson L.J., Holt M.R., Wheeler M.A., Wehnert M., Parsons M., and Ellis J.A. Defects in cell spreading and ERK1/2 activation in fibroblasts with lamin A/C mutations. Biochim. Biophys. Acta 1792 8 (2009 Aug) 810-821
15. Zhang Y.Q., and Sarge K.D. Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies. J. Cell. Biol. 182 1 (2008 Jul 14) 35-39
16. Crisp M., Liu Q., Roux K., Rattner J.B., Shanahan C., Burke B., et al. Coupling of the nucleus and cytoplasm: role of the LINC complex. J. Cell. Biol. 172 1 (2006 Jan 2) 41-53
17. Zhang Q., Bethmann C., Worth N.F., Davies J.D., Wasner C., Feuer A., et al. Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity. Hum. Mol. Genet. 16 23 (2007 Dec 1) 2816-2833
18. Puckelwartz M.J., Kessler E.J., Kim G., DeWitt M.M., Zhang Y., Earley J.U., et al. Nesprin-1 mutations in human and murine cardiomyopathy. J Mol Cell Cardiol 48 (2010) 600-608
19. Puckelwartz M., Kessler E., Zhang Y., Hodzic D., Randles K., Morris G., et al. Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice. Hum. Mol. Genet. 18 (2009) 607-620
20. Stewart C.L., Kozlov S., Fong L.G., and Young S.G. Mouse models of the laminopathies. Exp. Cell. Res. 313 10 (2007 Jun 10) 2144-2156
21. Wolf C.M., Wang L., Alcalai R., Pizard A., Burgon P.G., Ahmad F., et al. Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease. J. Mol. Cell. Cardiol. 44 2 (2008 Feb) 293-303
22. Sylvius N., Bilinska Z.T., Veinot J.P., Fidzianska A., Bolongo P.M., Poon S., et al. In vivo and in vitro examination of the functional significances of novel lamin gene mutations in heart failure patients. J. Med. Genet. 42 8 (2005 Aug) 639-647
23. Knoll R., Postel R., Wang J., Kratzner R., Hennecke G., Vacaru A.M., et al. Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. Circulation 116 5 (2007 Jul 31) 515-525