Isolation and pharmacological characterization of cannitoxin, a presynaptic neurotoxin from the venom of the papuan taipan (Oxyuranus scutellatus canni)

Journal of Pharmacology and Experimental Therapeutics

Volumn 315, Issue 3, 2005, Pages 1196-1202

  Kuruppu, Sanjaya ^a   Reeve, Shane ^a   Banerjee, Yajnavalka ^b   Kini, R Manjunatha ^b   Smith, A Ian ^a   Hodgson, Wayne C ^a  

^a MONASH UNIVERSITY   (Australia)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

4 BROMOPHENACYL BROMIDE; CANNITOXIN; NEUROTOXIN; NICOTINIC AGENT; PHOSPHOLIPASE A2; UNCLASSIFIED DRUG; VENOM; VENOM ANTISERUM;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ISOLATION; ENZYME ACTIVITY; ENZYME INHIBITION; GEL PERMEATION CHROMATOGRAPHY; MALE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SNAKE; TIC;

ACETOPHENONES; ALKYLATION; AMINO ACID SEQUENCE; ANIMALS; CHICKENS; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; ELAPID VENOMS; ELAPIDAE; ENZYME INHIBITORS; MALE; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MUSCLE CONTRACTION; MUSCLE, SKELETAL; NEURONS, EFFERENT; NEUROTOXINS; PAPUA NEW GUINEA; PHOSPHOLIPASES A; PROTEIN SUBUNITS; SEQUENCE ANALYSIS, PROTEIN; SEQUENCE HOMOLOGY, AMINO ACID; TIME FACTORS;

EID: 27744432871     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.093641     Document Type: Article

References (22)

1. Abe T, Alema S, and Miledi R (1977) Isolation and characterization of presynaptically acting neurotoxins from the venom of Bungarus snakes. Eur J Biochem 80:1-12.
2. Bell KL, Sutherland SK, and Hodgson WC (1998) Some pharmacological studies of venom from the inland taipan (Oxyuranus microlepidotus). Toxicon 36:63-74.
3. Broad AJ, Sutherland SK, and Coulter AR (1979) The lethality in mice of dangerous Australian and other snake venom. Toxicon 17:661-664.
4. Chang CC, Lee JD, Eaker D, and Fohlman J (1977) The presynaptic neuromuscular blocking action of taipoxin. A comparison with β-bungarotoxin and crotoxin. Toxicon 15:571-576.
5. Connolly S, Trevett AJ, Nwokolo NC, Lalloo DG, Naraqi S, Mantle D, Schofield IS, Fawcett PR, Harris JB, and Warrell DA (1995) Neuromuscular effects of Papuan taipan snake venom. Ann Neurol 38:916-920.
6. Crachi MT, Hammer LW, and Hodgson WC (1999a) A pharmacological examination of venom from the Papuan taipan (Oxyuranus scutellatus canni). Toxicon 37:1721-1734.
7. Crachi MT, Hammer LW, and Hodgson WC (1999b) The effects of antivenom on the in vitro neurotoxicity of venoms from the taipans Oxyuranus scutellatus, Oxyuranus microlepidotus and Oxyuranus scutellatus canni. Toxicon 37:1771-1778.
8. Fohlman J (1979) Comparison of two highly toxic Australian snake venoms: the taipan (Oxyuranus s. scutellatus) and the fierce snake (Parademansia microlepidotus). Toxicon 17:170-172.
9. Fohlman J, Eaker D, Dowdall MJ, Lullmann-Rauch R, Sjodin T, and Leander S (1979) Chemical modification of taipoxin and the consequences for phospholipase activity, pathophysiology and inhibition of high-affinity choline uptake. Eur J Biochem 94:531-540.
10. Fohlman J, Eaker D, Karlsson E, and Thesleff S (1976) Taipoxin, an extremely potent presynaptic neurotoxin from the venom of the Australian snake taipan (Oxyuranus s. scutellatus). Isolation, characterization, quaternary structure and pharmacological properties. Eur J Biochem 68:457-469.
11. Fohlman J, Lind P, and Eaker D (1977) Taipoxin, an extremely potent presynaptic snake venom neurotoxin. Elucidation of the primary structure of the acidic carbohydrate-containing taipoxin-subunit, a prophospholipase homolog. FEBS Lett 84:367-371.
12. Francis B, Williams ES, Seebart C, and Kaiser II (1993) Proteins isolated from the venom of the common tiger snake (Notechis scutatus scutatus) promote hypotension and hemorrhage. Toxicon 31:447-458.
13. Harris JB (1991) Phospholipases in snake venoms and their effects on nerve and muscle, in Snake toxins (Harvey AL ed) pp 91-129, Pergamon Press, New York.
14. Harvey AL (1990) Presynaptic effects of toxins. Int Rev Neurobiol 32:201-239.
15. Harvey AL, Barfaraz A, Thomson E, Faiz A, Preston S, and Harris JB (1994) Screening of snake venoms for neurotoxic and myotoxic effects using simple in vitro preparations from rodents and chicks. Toxicon 32:257-265.
16. O'Shea M (1996) A Guide to the Snakes of Papua New Guinea, Independent Group Pty Ltd., Singapore, Singapore.
17. Sutherland S and Tibballs J (2001) Australian Animal Toxins: the Creature, Their Toxins and Care of the Poisoned Patient, Oxford University Press, Melbourne, Australia.
18. 2. Biochemistry 13:1446-1454.
19. 2 myotoxin from the venom of the Irian Jayan death adder (Acanthophis rugosus). Br J Pharmacol 138:333-342.
20. Wickramaratna JC, Fry BG, Loiacono RE, Aguilar MI, Alewood PF, and Hodgson WC (2004) Isolation and characterization at cholinergic nicotinic receptors of a neurotoxin from the venom of the Acanthophis sp. Seram death adder. Biochem Pharmacol 68:383-394.
21. Worrell E (1970) Reptiles of Australia, Angus & Robertson, Sydney, Australia.
22. 2 Enzymes: Structure Function and Mechanism. (Kini RM ed) p 509, John Wiley & Sons, Ltd., Chichester, UK.