ASK-ing EMT not to spread cancer

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 7, 2010, Pages 2731-2732

  Kyprianou, Natasha ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CATENIN; BETA CATENIN; EPIDERMAL GROWTH FACTOR; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; SMAD PROTEIN; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR TWIST; TRANSFORMING GROWTH FACTOR BETA1;

APOPTOSIS; CELL ADHESION; CELL MIGRATION; CELL POLARITY; CELL SURVIVAL; EPITHELIUM CELL; HUMAN; MESENCHYME CELL; METASTASIS; NOTE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR GROWTH;

ADHERENS JUNCTIONS; CADHERINS; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL MOVEMENT; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL CELLS; HUMANS; MALE; MESODERM; NEOPLASM METASTASIS; PROSTATIC NEOPLASMS; RAS GTPASE-ACTIVATING PROTEINS;

EID: 77649243540     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0914721107     Document Type: Note

References (19)

1. Thiery JP, Sleeman JP (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7:131-142.
2. Thiery JP (2002) Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2:442-454.
3. Acloque H, Adams MS, Fishwick K, Bronner-Fraser M, Nieto MA (2009) Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest 119:1438-1449.
4. Grünert S, Jechlinger M, Beug H (2003) Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Nat Rev Mol Cell Biol 4:657-665.
5. Xie D, et al. (2010) The role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. Proc Natl Acad Sci USA 107:2485-2490.
6. Eger A, Stockinger A, Schaffhauser B, Beug H, Foisner R (2000) Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 transcriptional activity. J Cell Biol 148:173-188.
7. Thuault S, et al. (2008) HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition. J Biol Chem 283:33437-33446.
8. Derynck R, Akhurst RJ (2007) Differentiation plasticity regulated by TGF-β family proteins in development and disease. Nat Cell Biol 9:1000-1004.
9. Thuault S, et al. (2006) Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition. J Cell Biol 174:175-183.
10. Ozdamar B, et al. (2005) Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science 307:1603-1609.
11. Peinado H, Olmeda D, Cano A (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7:415-428.
12. Ghosh M, et al. (2004) Cofilin promotes actin polymerization and defines the direction of cell motility. Science 304:743-746.
13. Zhau HE, et al. (2008) Epithelial to mesenchymal transition (EMT) in human prostate cancer: lessons learned from ARCaP model. Clin Exp Metastasis 25:601-610.
14. Xie D, et al. (2009) DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis. Proc Natl Acad Sci USA 24:106:19878-19883.
15. Fuchs IB, et al. (2002) The prognostic significance of epithelial-mesenchymal transition in breast cancer. Anticancer Res 22 (6A):3415-3419.
16. Kwok WK, et al. (2005) Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target. Cancer Res 65:5153-5162.
17. Baritaki S, et al. (2009) Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction. Oncogene 28:3573-3585.
18. Zhu M-L, Kyprianou N (2010) Role of androgens and the androgen receptor in epithelial-mesenchymal-transition and invasion of prostate cancer cells. FASEB J 24:11-20.
19. Mulholland DJ, Cheng H, Reid K, Rennie PS, Nelson CC (2002) The androgen receptor can promote beta-catenin nuclear translocation independently of adenomatous polyposis coli. J Biol Chem277:17933-17943.