Enhancement of GABAA-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 7, 2010, Pages 3180-3185

  Mazzuferi, Manuela ^a,b   Palma, Eleonora ^c,d   Martinello, Katiuscia ^e   Maiolino, Francesca ^d   Roseti, Cristina ^c   Fucile, Sergio ^c,e   Fabene, Paolo F ^f   Schio, Federica ^f   Pellitteri, Michele ^f   Sperk, Guenther ^g   Miledi, Ricardo ^h,i   Eusebi, Fabrizio ^c,e   Simonato, Michele ^a,b  

^a Neuroscience Center   (Hong Kong)

^b UNIVERSITY OF FERRARA   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d IRCCS SAN RAFFAELE PISANA   (Italy)

^e IRCCS NEUROMED   (Italy)

^f UNIVERSITY OF VERONA   (Italy)

^g INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^h INSTITUTO DE NEUROBIOLOGÍA   (Mexico)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

GABAA receptor; Pilocarpine rat; Xenopus oocytes

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; PILOCARPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EPILEPTOGENESIS; HIPPOCAMPUS; NEOCORTEX; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RAT; TEMPORAL LOBE EPILEPSY; XENOPUS;

ANALYSIS OF VARIANCE; ANIMALS; ELECTROPHYSIOLOGY; EPILEPSY, TEMPORAL LOBE; FLUORESCENT ANTIBODY TECHNIQUE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; NEURONS; OOCYTES; ORGANIC CHEMICALS; PILOCARPINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SIGNAL TRANSDUCTION; XENOPUS;

ANIMALIA; RATTUS;

EID: 77649242601     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0914710107     Document Type: Article

References (40)

1. Pitkänen A, Sutula TP (2002) Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy. Lancet Neurol 1:173-181.
2. A receptor subtypes in human temporal lobe epilepsy. J Neurosci 20:5401-5419.
3. Loup F, Picard F, Yonekawa Y, Wieser HG, Fritschy JM (2009) Selective changes in GABAA receptor subtypes in white matter neurons of patients with focal epilepsy. Brain 132:2449-2463.
4. Palma E, et al. (2005) Abnormal GABAA receptors from the human epileptic hippocampal subiculum microtransplanted to Xenopus oocytes. Proc Natl Acad Sci USA 102:2514-2518.
5. Ragozzino D, et al. (2005) Rundown of GABA type A receptors is a dysfunction associated with human drug-resistant mesial temporal lobe epilepsy. Proc Natl Acad Sci USA 102:15219-15223.
6. A) "phasic" receptors. Proc Natl Acad Sci USA 104:20944-20948.
7. Palma E, et al. (2004) Phosphatase inhibitors remove the run-down of gammaaminobutyric acid type A receptors in the human epileptic brain. Proc Natl Acad Sci USA 101:10183-10188.
8. A receptors microtransplanted from the human epileptic brain to Xenopus oocytes. Proc Natl Acad Sci USA 102:1667-1672.
9. Roseti C, et al. (2008) Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors. Proc Natl Acad Sci USA 105:15118-15123.
10. Roseti C, et al. (2009) Blockage of A2A and A3 adenosine receptors decreases the desensitization of human GABA(A) receptors microtransplanted to Xenopus oocytes. Proc Natl Acad Sci USA 106:15927-15931.
11. A receptor glycolysis-dependent modulation in human partial epilepsy. Proc Natl Acad Sci USA 104:3472-3477.
12. Fabene PF, et al. (2008) A role for leukocyte-endothelial adhesion mechanisms in epilepsy. Nat Med 14:1377-1383.
13. Vezzani A (2009) Pilocarpine-induced seizures revisited: What does the model mimic? Epilepsy Curr 9:146-148.
14. Pitkanen A, Schwartzkroin PA, Moshè SL (2006) Models of seizures and epilepsy (Elsevier Academic Press, Burlington, MA).
15. Racine RJ (1972) Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 32:281-294.
16. Goffin K, Nissinen J, Van Laere K, Pitkänen A (2007) Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat. Exp Neurol 205: 501-505.
17. Curia G, Longo D, Biagini G, Jones RS, Avoli M (2008) The pilocarpine model of temporal lobe epilepsy. J Neurosci Methods 172:143-157.
18. Paradiso B, et al. (2009) Localized delivery of fibroblast growth factor-2 and brainderived neurotrophic factor reduces spontaneous seizures in an epilepsy model. Proc Natl Acad Sci USA 106:7191-7196.
19. Schmued LC, Stowers CC, Scallet AC, Xu L (2005) Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons. Brain Res 1035:24-31.
20. Garzillo CL, Mello LE (2002) Characterization of reactive astrocytes in the chronic phase of the pilocarpine model of epilepsy. Epilepsia 43 (Suppl 5):107-109.
21. Miledi R, Palma E, Eusebi F (2006) Microtransplantation of neurotransmitter receptors from cells to Xenopus oocyte membranes: New procedure for ion channel studies. Methods Mol Biol 322:347-355.
22. Eusebi F, Palma E, Amici M, Miledi R (2009) Microtransplantation of ligand-gated receptor-channels from fresh or frozen nervous tissue into Xenopus oocytes: A potent tool for expanding functional information. Prog Neurobiol 88:32-40.
23. Palma E, et al. (2003) Microtransplantation of membranes from cultured cells to Xenopus oocytes: A method to study neurotransmitter receptors embedded in native lipids. Proc Natl Acad Sci USA 100:2896-2900.
24. Brooks-Kayal AR, Shumate MD, Jin H, Rikhter TY, Coulter DA (1998) Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy. Nat Med 4:1166-1172.
25. Peng Z, Houser CR (2005) Temporal patterns of fos expression in the dentate gyrus after spontaneous seizures in a mouse model of temporal lobe epilepsy. J Neurosci 25: 7210-7220.
26. Sperk G, Furtinger S, Schwarzer C, Pirker S (2004) Recent Advances in Epilepsy Research, eds Binder DK, Scharfman HE (Kluwer Academic/Plenum Publishers, New York, NY), pp 92-103.
27. A receptors in status epilepticus. Epilepsia 48 (Suppl 8):11-13.
28. Zhang G, Raol YH, Hsu FC, Coulter DA, Brooks-Kayal AR (2004) Effects of status epilepticus on hippocampal GABAA receptors are age-dependent. Neuroscience 125: 299-303.
29. A receptor subunits in seizure-prone and seizure-resistant rat models of temporal lobe epilepsy. J Neurosci 19:4654-4661.
30. A) receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy. J Neurosci 26:11342-11346.
31. A receptors to synaptic and extrasynaptic GABA. J Physiol 578:655-676.
32. Sperk G, Wieselthaler-Hoelzl A, Drexel M (2009) Encyclopedia of Basic Epilepsy Research, ed Schwartzkroin P (Elsevier/Academic Press, Amsterdam), pp 10351-10356.
33. A) receptor subunits in the rat hippocampus II: Altered distribution in kainic acid-induced temporal lobe epilepsy. Neuroscience 80: 1001-1017.
34. Nishimura T, et al. (2005) Altered expression of GABA(A) and GABA(B) receptor subunit mRNAs in the hippocampus after kindling and electrically induced status epilepticus. Neuroscience 134:691-704.
35. Zhang N, Wei W, Mody I, Houser CR (2007) Altered localization of GABA(A) receptor subunits on dentate granule cell dendrites influences tonic and phasic inhibition in a mouse model of epilepsy. J Neurosci 27:7520-7531.
36. A) receptor beta-subunits in the hippocampus of patients with temporal lobe epilepsy. J Neuropathol Exp Neurol 62: 820-834.
37. Paxinos G, Watson C (1982) The Rat Brain in Stereotaxic Coordinates (Academic Press, New York, USA).
38. Zucchini S, et al. (2008) Fgf-2 overexpression increases excitability and seizure susceptibility but decreases seizure-induced cell loss. J Neurosci 28:13112-13124.
39. A) receptor subunits in the rat hippocampus I: Immunocytochemical distribution of 13 subunits. Neuroscience 80:987-1000.
40. A) receptors: Immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 101:815-850.