Guanylate-binding protein 2 mRNA in peripheral blood leukocytes of liver transplant recipients as a marker for acute cellular rejection

Transplant International

Volumn 23, Issue 4, 2010, Pages 390-396

  Kobayashi, Shogo ^a   Nagano, Hiroaki ^a   Marubashi, Shigeru ^a   Hama, Naoki ^a   Asaoka, Tadafumi ^a   Eguchi, Hidetoshi ^a   Takeda, Yutaka ^a   Tanemura, Masahiro ^a   Doki, Yuichiro ^a   Mori, Masaki ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Acute cellular rejection; Guanylate binding protein 2 (GBP2); Interferon regulatory factor 1 (IRF1); Liver transplantation; Peripheral blood leukocytes

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN 2; INTERFERON REGULATORY FACTOR 1; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; GBP2 PROTEIN, HUMAN; MESSENGER RNA;

ACUTE GRAFT REJECTION; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; FEMALE; GENE EXPRESSION; HEPATITIS C; HUMAN; LIVER BIOPSY; LIVER DYSFUNCTION; LIVER TRANSPLANTATION; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RECEIVER OPERATING CHARACTERISTIC; RECIPIENT; SENSITIVITY AND SPECIFICITY; BIOPSY; BIOSYNTHESIS; CHEMISTRY; CYTOLOGY; GRAFT REJECTION; LEUKOCYTE; LIVER; METABOLISM; MIDDLE AGED; PATHOLOGY;

BIOLOGICAL MARKERS; BIOPSY; FEMALE; GRAFT REJECTION; GTP-BINDING PROTEINS; HUMANS; LEUKOCYTES; LIVER; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; RNA, MESSENGER; ROC CURVE; SENSITIVITY AND SPECIFICITY;

EID: 77649239802     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2009.00991.x     Document Type: Article

References (27)

1. Wiesner RH, Ludwig J, Krom RA, Hay JE, van Hoek B. Hepatic allograft rejection: new developments in terminology, diagnosis, prevention, and treatment. Mayo Clin Proc 1993 68 : 69.
2. Van Buskirk AM, Pidwell DJ, Adams PW, Orosz CG. Transplantation immunology. JAMA 1997 278 : 1993.
3. Martinez OM, Rosen HR. Basic concepts in transplant immunology. Liver Transpl 2005 11 : 370.
4. Liu LU, Bodian CA, Gondolesi GE, et al. Marked differences in acute cellular rejection rates between living-donor and deceased-donor liver transplant recipients. Transplantation 2005 80 : 1072.
5. Rockey DC, Caldwell SH, Goodman ZD, Nelson RC, Smith AD. Liver biopsy. Hepatology 2009 49 : 1017.
6. Hama N, Yanagisawa Y, Dono K, et al. Gene expression profiling of acute cellular rejection in rat liver transplantation using DNA microarrays. Liver Transpl 2009 15 : 509.
7. Banff schema for grading liver allograft rejection: an international consensus document. Hepatology 1997 25 : 658.
8. Ormonde DG, de Boer WB, Kierath A, et al. Banff schema for grading liver allograft rejection: utility in clinical practice. Liver Transpl Surg 1999 5 : 261.
9. Netto GJ, Watkins DL, Williams JW, et al. Interobserver agreement in hepatitis C grading and staging and in the Banff grading schema for acute cellular rejection: the "hepatitis C 3" multi-institutional trial experience. Arch Pathol Lab Med 2006 130 : 1157.
10. Nagakawa Y, Nomoto S, Kato Y, et al. Over-expression of AIF-1 in liver allografts and peripheral blood correlates with acute rejection after transplantation in rats. Am J Transplant 2004 4 : 1949.
11. Sakamoto R, Asonuma K, Zeledon Ramirez ME, Yoshimoto K, Nishimori A, Inomata Y. Forkhead Box P3 (FOXP3) mRNA expression immediately after living-donor liver transplant. Exp Clin Transplant 2009 7 : 8.
12. Pons JA, Revilla-Nuin B, Baroja-Mazo A, et al. FoxP3 in peripheral blood is associated with operational tolerance in liver transplant patients during immunosuppression withdrawal. Transplantation 2008 86 : 1370.
13. Boleslawski E, BenOthman S, Grabar S, et al. CD25, CD28 and CD38 expression in peripheral blood lymphocytes as a tool to predict acute rejection after liver transplantation. Clin Transplant 2008 22 : 494.
14. Wang YL, Zhang YY, Li G, et al. Correlation of CD95 and soluble CD95 expression with acute rejection status of liver transplantation. World J Gastroenterol 2005 11 : 1700.
15. Fragale A, Gabriele L, Stellacci E, et al. IFN regulatory factor-1 negatively regulates CD4+ CD25+ regulatory T-cell differentiation by repressing Foxp3 expression. J Immunol 2008 181 : 1673.
16. Briken V, Ruffner H, Schultz U, et al. Interferon regulatory factor 1 is required for mouse GBP gene activation by gamma interferon. Mol Cell Biol 1995 15 : 975.
17. Ramsauer K, Farlik M, Zupkovitz G, et al. Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-gamma-inducible gbp2 gene. Proc Natl Acad Sci USA 2007 104 : 2849.
18. Lew DJ, Decker T, Strehlow I, Darnell JE. Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons. Mol Cell Biol 1991 11 : 182.
19. Lehtonen A, Matikainen S, Julkunen I. Interferons up-regulate STAT1, STAT2, and IRF family transcription factor gene expression in human peripheral blood mononuclear cells and macrophages. J Immunol 1997 159 : 794.
20. Decker T, Kovarik P. Transcription factor activity of STAT proteins: structural requirements and regulation by phosphorylation and interacting proteins. Cell Mol Life Sci 1999 55 : 1535. 26.
21. Carter CC, Gorbacheva VY, Vestal DJ. Inhibition of VSV and EMCV replication by the interferon-induced GTPase, mGBP-2: differential requirement for wild-type GTP binding domain. Arch Virol 2005 150 : 1213.
22. Vestal DJ, Buss JE, Kelner GS, Maciejewski D, Asundi VK, Maki RA. Rat p67 GBP is induced by interferon-gamma and isoprenoid-modified in macrophages. Biochem Biophys Res Commun 1996 224 : 528.
23. Gorbacheva VY, Lindner D, Sen GC, Vestal DJ. The interferon (IFN)-induced GTPase, mGBP-2. Role in IFN-gamma-induced murine fibroblast proliferation. J Biol Chem 2002 277 : 6080.
24. Arias-Diaz J, Ildefonso JA, Muñoz JJ, Zapata A, Jiménez E. Both tacrolimus and sirolimus decrease Th1/Th2 ratio, and increase regulatory T-lymphocytes in the liver after ischemia/reperfusion. Lab Invest 2009 89 : 433.
25. Martínez-Llordella M, Lozano JJ, Puig-Pey I, et al. Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients. J Clin Invest 2008 118 : 2845.
26. Nagano H, Libby P, Taylor MK, et al. Coronary arteriosclerosis after T-cell-mediated injury in transplanted mouse hearts: Role of interferon-gamma. Am J Pathol 1998 152 : 1187.
27. Nagano H, Mitchell RN, Taylor MK, Hasegawa S, Tilney NL, Libby P. Interferon-gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts. J Clin Invest 1997 100 : 550.