A single amino acid change in CaV1.2 channels eliminates the permeation and gating differences between Ca2+ and Ba2+

Journal of Membrane Biology

Volumn 233, Issue 1-3, 2010, Pages 23-33

  Li, Zhe ^a,b   Wang, Xianming ^b   Gao, Guofeng ^b   Qu, Dongmei ^b,c   Yu, Buwei ^c   Huang, Congxin ^a   Elmslie, Keith S ^b   Peterson, Blaise Z ^b  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Electrophysiology; Mutation; Outer vestibule; Pore; Selectivity filter; Surface charge; Voltage dependent

Indexed keywords

BARIUM ION; CALCIUM CHANNEL CAV1.2; CALCIUM CHANNEL L TYPE; CALCIUM ION; GLUTAMIC ACID; PHENYLALANINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CALCIUM BINDING; CATION TRANSPORT; CHANNEL GATING; CONTROLLED STUDY; ION CONDUCTANCE;

BARIUM; BIOLOGICAL TRANSPORT; CALCIUM; CALCIUM CHANNELS, L-TYPE; CELL LINE; ELECTROPHYSIOLOGY; GLUTAMATES; HUMANS; ION CHANNEL GATING; MUTAGENESIS, SITE-DIRECTED; PATCH-CLAMP TECHNIQUES;

EID: 77649232069     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-009-9221-1     Document Type: Article

References (42)

1. 2+ block the pore of inactivated channels? J Gen Physiol 129 477 483 10.1085/jgp.200709734 1:CAS:528:DC%2BD2sXnsVSmu70%3D 17535960 (Pubitemid 46849147)
2. BP Bean 1985 Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity and pharmacology J Gen Physiol 86 1 30 10.1085/jgp.86.1.1 1:CAS:528:DyaL2MXkvVGrsro%3D 2411846 (Pubitemid 15073063)
3. L Byerly PB Chase JR Stimers 1985 Permeation and interaction of divalent cations in calcium channels of snail neurons J Gen Physiol 85 491 518 10.1085/jgp.85.4.491 1:CAS:528:DyaL2MXitVWkur0%3D 2409216 (Pubitemid 15120686)
4. WA Catterall E Perez-Reyes TP Snutch J Striessnig 2005 International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels Pharmacol Rev 57 411 425 10.1124/pr.57.4.5 1:CAS:528:DC%2BD28XhtFWgu7w%3D 16382099 (Pubitemid 43036432)
5. 2+ channels J Gen Physiol 130 415 425 10.1085/jgp.200709771 1:CAS:528:DC%2BD2sXht1WmsrjJ 17893194 (Pubitemid 47481604)
6. AM Corbett MA Vanderklok 1994 Sodium-channel subtypes in the rat display functional differences in the presence of veratridine Biochem Biophys Res Commun 199 1305 1312 10.1006/bbrc.1994.1373 1:CAS:528:DyaK2cXitlOrt70%3D 8147874 (Pubitemid 24174801)
7. G Cota E Stefani 1984 Saturation of calcium channels and surface charge effects in skeletal muscle fibres of the frog J Physiol 351 135 154 1:STN:280:DyaL2c3mslCntA%3D%3D 6086902
8. 2+-dependent inactivation in the pore region of Ca(v)1.2 Mol Pharmacol 64 491 501 10.1124/mol.64.2.491 1:CAS:528:DC%2BD3sXlvVCnsLc%3D 12869655 (Pubitemid 36910014)
9. 2+ potentiation of verapamil block in the pore region of Ca(v)1.2 Mol Pharmacol 66 1236 1247 10.1124/mol.104.000893 1:CAS:528:DC%2BD2cXptVKmtLs%3D 15286207 (Pubitemid 39411063)
10. V Ganitkevich MF Shuba SV Smirnov 1988 Saturation of calcium channels in single isolated smooth muscle cells of guinea-pig taenia caeci J Physiol 399 419 436 2457091
11. DA Hanck MF Sheets 1992 Extracellular divalent and trivalent cation effects on sodium current kinetics in single canine cardiac Purkinje cells J Physiol 454 267 298 1:CAS:528:DyaK38Xks1Ogurc%3D 1335501
12. Hille B (2001) Ion channels of excitable membranes, 3rd edn. Sinaur Associates, Sunderland, MA
13. B Hille AM Woodhull BI Shapiro 1975 Negative surface charge near sodium channels of nerve: divalent ions, monovalent ions, and pH Philos Trans R Soc Lond B Biol Sci 270 301 318 10.1098/rstb.1975.0011 1:CAS:528:DyaE2MXkvFCntLY%3D 238230
14. V3.2 low-voltage-activated T-type calcium channels Jpn J Physiol 53 165 172 10.2170/jjphysiol.53.165 1:CAS:528:DC%2BD3sXos1eju7o%3D 14529577 (Pubitemid 37229291)
15. RS Kass DS Krafte 1987 Negative surface charge density near heart calcium channels. Relevance to block by dihydropyridines J Gen Physiol 89 629 644 10.1085/jgp.89.4.629 1:CAS:528:DyaL2sXitFWltb0%3D 2438373 (Pubitemid 17061383)
16. + J Gen Physiol 132 223 238 10.1085/jgp.200809986 1:CAS:528:DC%2BD1cXhtVeksbnP 18663131
17. N Klugbauer E Marais L Lacinova, et al. 1999 A T-type calcium channel from mouse brain Pflugers Arch 437 710 715 10.1007/s004240050836 1:CAS:528:DyaK1MXhvVagurY%3D 10087148 (Pubitemid 29161927)
18. PG Kostyuk SL Mironov YM Shuba 1983 Two selective filters in the calcium channel of the molluscan neuron somatic membrane Neurophysiology 15 314 319 10.1007/BF01059873
19. JY Li L Stevens N Klugbauer, et al. 2004 Roles of molecular regions in determining differences between voltage dependence of activation of Ca(v)3.1 and Ca(v)1.2 calcium channels J Biol Chem 279 26858 26867 10.1074/jbc.M313981200 1:CAS:528:DC%2BD2cXkvFGgu7w%3D 15100229 (Pubitemid 38812519)
20. JY Li L Stevens D Wray 2005 Molecular regions underlying the activation of low- and high-voltage activating calcium channels Eur Biophys J 34 1017 1029 10.1007/s00249-005-0487-7 1:CAS:528:DC%2BD2MXht1SksbvP 15924245 (Pubitemid 41609290)
21. TN Marks SW Jones 1992 Calcium currents in the A7r5 smooth muscle-derived cell line. An allosteric model for calcium channel activation and dihydropyridine agonist action J Gen Physiol 99 367 390 10.1085/jgp.99.3.367 1:CAS:528:DyaK38XisVyisL4%3D 1316936
22. + channel from toad skeletal muscle Biophys J 64 1038 1050 10.1016/S0006-3495(93)81469-3 1:CAS:528:DyaK3sXisV2ru70%3D 8388264
23. H Ohmori M Yoshii 1977 Surface potential reflected in both gating and permeation mechanisms of sodium and calcium channels of the tunicate egg cell membrane J Physiol 267 429 463 1:STN:280:DyaE2s3gvFKrtg%3D%3D 17734
24. E Perez-Reyes A Castellano HS Kim, et al. 1992 Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel J Biol Chem 267 1792 1797 1:CAS:528:DyaK3sXhtF2it78%3D 1370480
25. BZ Peterson WA Catterall 2006 Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore Mol Pharmacol 70 667 675 10.1124/mol.105.020644 1:CAS:528:DC%2BD28XnslyjsLY%3D 16675661 (Pubitemid 44092327)
26. 2+-dependent inactivation of L-type calcium channels Neuron 22 549 558 10.1016/S0896-6273(00)80709-6 1:CAS:528:DyaK1MXit1emtrk%3D 10197534
27. 2+ channels Biophys J 78 1906 1920 10.1016/S0006-3495(00)76739-7 1:CAS:528:DC%2BD3cXisVWgtLg%3D 10733970
28. 2+ channel depends on calmodulin Proc Natl Acad Sci USA 96 2435 2438 10.1073/pnas.96.5.2435 1:CAS:528:DyaK1MXhvVSqtbc%3D 10051660 (Pubitemid 29117933)
29. WA Sather EW McCleskey 2003 Permeation and selectivity in calcium channels Annu Rev Physiol 65 133 159 10.1146/annurev.physiol.65.092101.142345 1:CAS:528:DC%2BD3sXjt1Glt70%3D 12471162 (Pubitemid 38249150)
30. FJ Sigworth 1977 Na-current fluctuations give estimates of single-channel conductance in frog nerve Biophys J 17 A10 A10
31. FJ Sigworth 1980 The variance of sodium current fluctuations at the node of Ranvier J Physiol 307 97 129 1:STN:280:DyaL3M7ksVylsg%3D%3D 6259340
32. PA Smith FM Aschroft CM Fewtrell 1993 Permeation and gating properties of the L-type calcium channel in mouse pancreatic beta cells J Gen Physiol 101 767 797 10.1085/jgp.101.5.767 1:CAS:528:DyaK3sXmtVSht7o%3D 7687645
33. WJ Tomlinson A Stea E Bourinet, et al. 1993 Functional properties of a neuronal class C L-type calcium channel Neuropharmacology 32 1117 1126 10.1016/0028-3908(93)90006-O 1:CAS:528:DyaK2cXltFSitA%3D%3D 8107966 (Pubitemid 23322108)
34. X Wang TA Ponoran RL Rasmusson, et al. 2005 Amino acid substitutions in the pore of the Ca(V)1.2 calcium channel reduce barium currents without affecting calcium currents Biophys J 89 1731 1743 10.1529/biophysj.104.058875 1:CAS:528:DC%2BD2MXpvF2ktbY%3D 15980164 (Pubitemid 41233530)
35. X Wang L Du BZ Peterson 2007 Calcicludine binding to the outer pore of L-type calcium channels is allosterically coupled to dihydropyridine binding Biochemistry 46 7590 7598 10.1021/bi7001696 1:CAS:528:DC%2BD2sXlvVymsr0%3D 17536837 (Pubitemid 46986383)
36. 2+ channels J Biol Chem 266 21943 21947 1:CAS:528:DyaK3MXmtVWgs78%3D 1718988
37. 2+ channels Biophys J 77 2575 2589 10.1016/S0006-3495(99)77092-X 1:CAS:528:DyaK1MXnt1Wktbo%3D 10545358
38. DL Wilson K Morimoto Y Tsuda, et al. 1983 Interaction between calcium ions and surface charge as it relates to calcium currents J Membr Biol 72 117 130 10.1007/BF01870319 1:STN:280:DyaL3s3hs1Slsg%3D%3D 6304316
39. V1.2 (L-type) channels: multiple altered gating mechanisms and pharmacological restoration of inactivation J Physiol 587 551 565 10.1113/jphysiol.2008.161737 1:CAS:528:DC%2BD1MXitlGjtbs%3D 19074970
40. GW Zamponi TP Snutch 1996 Evidence for a specific site for modulation of calcium channel activation by external calcium ions Pflugers Arch 431 470 472 10.1007/BF02207290 1:CAS:528:DyaK28XjtFagurs%3D 8584446
41. J Zheng FJ Sigworth 1997 Selectivity changes during activation of mutant Shaker potassium channels J Gen Physiol 110 101 117 10.1085/jgp.110.2.101 1:CAS:528:DyaK2sXls1Smsb4%3D 9236204 (Pubitemid 27340483)
42. RD Zuhlke GS Pitt K Deisseroth, et al. 1999 Calmodulin supports both inactivation and facilitation of L-type calcium channels Nature 399 159 162 10.1038/20200 1:CAS:528:DyaK1MXjsVOht7o%3D 10335846 (Pubitemid 29230436)