Interpreting metabolomic profiles using unbiased pathway models

PLoS Computational Biology

Volumn 6, Issue 2, 2010, Pages

  Deo, Rahul C ^a,b   Hunter, Luke ^a   Lewis, Gregory D ^b,c   Pare, Guillaume ^a   Vasan, Ramachandran S ^d,e   Chasman, Daniel ^a   Wang, Thomas J ^b,d   Gerszten, Robert E ^b,c   Roth, Frederick P ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d FRAMINGHAM HEART STUDY   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMOLECULES; GLUCOSE; METABOLISM; PRINCIPAL COMPONENT ANALYSIS;

DISEASE PHENOTYPES; GENETIC FACTORS; HUMAN DISEASE; IMPAIRED GLUCOSE TOLERANCES; METABOLIC NETWORK; METABOLITE LEVEL; METABOLITE PROFILES; METABOLOMICS; ORAL GLUCOSE TOLERANCE TESTS; SOLUTE CARRIERS;

METABOLITES;

AMINO ACID TRANSPORTER; CARRIER PROTEIN; PROTEIN SLC25A13; PROTEIN SLC6A12; UNCLASSIFIED DRUG; BETAINE PLASMA MEMBRANE TRANSPORT PROTEINS; GLUCOSE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; IMPAIRED GLUCOSE TOLERANCE; METABOLISM; METABOLITE; METABOLOMICS; ORAL GLUCOSE TOLERANCE TEST; PRINCIPAL COMPONENT ANALYSIS; REGULATORY MECHANISM; BIOLOGICAL MODEL; BIOLOGY; CLUSTER ANALYSIS; DISORDERS OF CARBOHYDRATE METABOLISM; EXTRACELLULAR SPACE; GLUCOSE TOLERANCE TEST; INTRACELLULAR SPACE; METABOLOME; METHODOLOGY; PHYSIOLOGY;

AMINO ACID TRANSPORT SYSTEMS; CARRIER PROTEINS; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; EXTRACELLULAR SPACE; GLUCOSE; GLUCOSE METABOLISM DISORDERS; GLUCOSE TOLERANCE TEST; HUMANS; INTRACELLULAR SPACE; METABOLIC NETWORKS AND PATHWAYS; METABOLOME; MODELS, BIOLOGICAL; PRINCIPAL COMPONENT ANALYSIS;

EID: 77649229357     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000692     Document Type: Article

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