Linking scientific discovery and better health for the nation: The first three years of the NIH's clinical and translational science awards

Academic Medicine

Volumn 85, Issue 3, 2010, Pages 457-462

  Califf, Robert M ^a   Berglund, Lars ^b  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77649216009     PISSN: 10402446     EISSN: None     Source Type: Journal    
DOI: 10.1097/ACM.0b013e3181ccb74d     Document Type: Article

References (27)

1. Wyngaarden JB. The clinical investigator as an endangered species. N Engl J Med. 1979; 301:1254-1259.
2. Sung NS, Crowley WF Jr, Genel M, et al. Central challenges facing the national clinical research enterprise. JAMA. 2003;289:1278-1287.
3. FitzGerald GA. Opinion: Anticipating change in drug development: The emerging era of translational medicine and therapeutics. Nat Rev Drug Discov. 2005;4: 815-818.
4. Andrews NC. The other physician-scientist problem: Where have all the young girls gone? Nat Med. 2002;8:439-441.
5. Snyderman R. The clinical researcher-An "emerging" species. JAMA. 2004;291:882-883.
6. Coller BS. Translational research: Forging a new cultural identity. Mount Sinai J Med. 2008;74:478-487.
7. Ley TJ, Rosenberg LE. The physician-scientist career pipeline in 2005: Build it, and they will come. JAMA. 2005;294:1343-1351.
8. Nathan DG. Clinical research: Perceptions, reality, and proposed solutions. National Institutes of Health Director's Panel on Clinical Research. JAMA. 1998;280:1427-1431.
9. Nathan DG, Schechter AN. NIH support for basic and clinical research: Biomedical researcher angst in 2006. JAMA. 2006;295: 2656-2658.
10. Promoting Translational and Clinical Science: The Critical Role of Medical Schools and Teaching Hospitals. Report of the AAMC's Task Force II on Clinical Research. Washington, DC: Association of American Medical Colleges; 2006.
11. Ausiello D. Science education and communication: AAP presidential address. J Clin Invest. 2007;117:3128-3130.
12. Olsen L, Aisner D, McGinnis JM, eds. The Learning Healthcare System: Workshop Summary (IOM Roundtable on Evidence- Based Medicine). Washington, DC: National Academies Press; 2007. Available at: http:// www.nap.edu/catalog.php? record-id-11903. Accessed September 14, 2009.
13. Zerhouni E. Medicine. The NIH Roadmap. Science. 2003;302:63-72.
14. National Institutes of Health. NIH launches major program to transform clinical and translational science [press release]. Available at: http://www.nih.gov/news/pr/oct2005/ ncrr-12.htm. Accessed September 14, 2009.
15. National Institutes of Health. NIH Roadmap for Medical Research. Available at: http:// nihroadmap.nih.gov/overview.asp. Accessed September 11, 2009.
16. Clinical and Translational Science Awards. NCRR Fact Sheet: Clinical and Translational Science Awards. Available at: http://www. ctsaweb.org/docs/CTSA- FactSheet.pdf. Accessed September 14, 2009.
17. National Center for Research Resources. CTSA Progress Report-2009. Available at: www.ncrr.nih.gov/ctsa/progress-report-2009. Accessed September 11, 2009.
18. Braunwald E. Departments, divisions and centers in the evolution of medical schools. Am J Med. 2006;119:457-462.
19. Reis SE, Berglund L, Bernard GR, et al. Reengineering the national clinical and translational research enterprise: The strategic plan of the National Clinical and Translational Science Awards Consortium. Acad Med. 2010;85:463-469.
20. Califf RM. The clinical research site-The underappreciated component of the clinical research system. JAMA. 2009;302:2025-2027.
21. Califf RM. Clinical trials bureaucracy: Unintended consequences of a wellintentioned policy. Clin Trials. 2006;3:496-502.
22. Fost N, Levine RJ. The dysregulation of human subjects research. JAMA. 2007;298: 2196-2198.
23. Getz KA. Have we pushed our PIs too far? Appl Clin Trials. 2005;14:34-36.
24. ClinicalTrials.gov. Comparison of Surgical and Medical Treatment for Congestive Heart Failure and Coronary Artery Disease (STICH). Available at: http://www.clinicaltrials.gov/ct2/ show/NCT00023595?term-Stich&rank-1. Accessed September 11, 2009.
25. ClinicalTrials.gov. Occluded Artery Trial (OAT). Available at: http://www.clinicaltrials. gov/ct2/show/NCT00004562?term- OAT&rank-8. Accessed September 11, 2009.
26. Glickman SW, McHutchison JG, Peterson ED, et al. Ethical and scientific implications of the globalization of clinical research. N Engl J Med. 2009;360:816-823.
27. Bernstam EV, Hersh WR, Johnson SB, et al. Synergies and distinctions between computational disciplines in biomedical research: Perspective from the Clinical and Translational Science Award programs. Acad Med. 2009;84:964-970.