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Volumn 75, Issue 5, 2008, Pages 478-487

Translational research: Forging a new cultural identity

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CLINICAL PRACTICE; CLOTHING; EVIDENCE BASED MEDICINE; HEALTH CARE DELIVERY; HEALTH CARE FINANCING; HEALTH CARE NEED; HEALTH CARE QUALITY; HEALTH PROMOTION; HUMAN; MEDICAL DECISION MAKING; MEDICAL EDUCATION; MEDICAL ERROR; MEDICAL ETHICS; MEDICAL RESEARCH; MOTIVATION; PHYSICIAN ATTITUDE; PROFESSIONAL STANDARD; TRANSLATIONAL RESEARCH;

EID: 57149097087     PISSN: 00272507     EISSN: 19317581     Source Type: Journal    
DOI: 10.1002/msj.20064     Document Type: Article
Times cited : (29)

References (32)
  • 1
    • 0031570526 scopus 로고    scopus 로고
    • The clinical investigator: Bewitched, bothered, and bewildered-but still beloved
    • Goldstein JL, Brown MS. The clinical investigator: bewitched, bothered, and bewildered-but still beloved. J Clin Invest 1997; 99: 2803-2812.
    • (1997) J Clin Invest , vol.99 , pp. 2803-2812
    • Goldstein, J.L.1    Brown, M.S.2
  • 2
    • 57149089636 scopus 로고    scopus 로고
    • Congressional Budget Office. Research and development in the pharmaceutical industry. Available at: http://www.cbo.gov/ftpdocs/76xx/ doc7615/10-02-drugr-d.pdf. 2006; Accessed July 2008.
    • Congressional Budget Office. Research and development in the pharmaceutical industry. Available at: http://www.cbo.gov/ftpdocs/76xx/ doc7615/10-02-drugr-d.pdf. 2006; Accessed July 2008.
  • 3
    • 33746872608 scopus 로고    scopus 로고
    • A proposal for radical changes in the drug-approval process
    • Wood AJ. A proposal for radical changes in the drug-approval process. N Engl J Med 2006; 355: 618-623.
    • (2006) N Engl J Med , vol.355 , pp. 618-623
    • Wood, A.J.1
  • 4
    • 57149116332 scopus 로고    scopus 로고
    • It's alive! Meet one of biotech's zombies
    • February 11
    • Pollack, A. It's alive! Meet one of biotech's zombies. New York Times February 11, 2007.
    • (2007) New York Times
    • Pollack, A.1
  • 5
    • 66149171440 scopus 로고    scopus 로고
    • Big pharma faces grim prognosis: Industry fails to find new drugs to replace wonders like Lipitor
    • December 6
    • Martinez B, Goldstein J. Big pharma faces grim prognosis: industry fails to find new drugs to replace wonders like Lipitor. Wall Street Journal December 6, 2007.
    • (2007) Wall Street Journal
    • Martinez, B.1    Goldstein, J.2
  • 6
    • 33749490064 scopus 로고    scopus 로고
    • Saving the clinician-scientist: Report of the ANA long range planning committee
    • Hauser SL, McArthur JC. Saving the clinician-scientist: report of the ANA long range planning committee. Ann Neurol 2006; 60: 278-285.
    • (2006) Ann Neurol , vol.60 , pp. 278-285
    • Hauser, S.L.1    McArthur, J.C.2
  • 7
    • 25144502974 scopus 로고    scopus 로고
    • The physician-scientist career pipeline in 2005: Build it, and they will come
    • Ley TJ, Rosenberg LE. The physician-scientist career pipeline in 2005: build it, and they will come. JAMA 2005; 294: 1343-1351.
    • (2005) JAMA , vol.294 , pp. 1343-1351
    • Ley, T.J.1    Rosenberg, L.E.2
  • 8
    • 0032576177 scopus 로고    scopus 로고
    • Clinical research: Perceptions, reality, and proposed solutions. National Institutes of Health Director's Panel on Clinical Research
    • Nathan DG. Clinical research: perceptions, reality, and proposed solutions. National Institutes of Health Director's Panel on Clinical Research. JAMA 1998; 280: 1427-1431.
    • (1998) JAMA , vol.280 , pp. 1427-1431
    • Nathan, D.G.1
  • 9
    • 33745114782 scopus 로고    scopus 로고
    • NIH support for basic and clinical research: Biomedical researcher angst in 2006
    • Nathan DG, Schechter AN. NIH support for basic and clinical research: biomedical researcher angst in 2006. JAMA 2006; 295: 2656-2658.
    • (2006) JAMA , vol.295 , pp. 2656-2658
    • Nathan, D.G.1    Schechter, A.N.2
  • 10
    • 68149164409 scopus 로고    scopus 로고
    • Promoting Translational and Clinical Science: The Critical Role of Medical Schools and Teaching Hospitals
    • 1-63. Washington, DC: Association of American Medical Colleges;
    • Promoting Translational and Clinical Science: The Critical Role of Medical Schools and Teaching Hospitals. Report of the AAMCs Task Force II on Clinical Research, 1-63. Washington, DC: Association of American Medical Colleges; 2006.
    • (2006) Report of the AAMCs Task Force II on Clinical Research
  • 11
    • 0028876339 scopus 로고
    • Blockade of platelet GPIIb/IIIa receptors as an antithrombotic strategy
    • Coller BS. Blockade of platelet GPIIb/IIIa receptors as an antithrombotic strategy. Circulation 1995; 92: 2373-2380.
    • (1995) Circulation , vol.92 , pp. 2373-2380
    • Coller, B.S.1
  • 12
    • 0018857958 scopus 로고
    • Interaction of normal, thrombasthenic, and Bernard-Soulier platelets with immobilized fibrinogen: Defective platelet-fibrinogen interaction in thrombasthenia
    • Coller BS. Interaction of normal, thrombasthenic, and Bernard-Soulier platelets with immobilized fibrinogen: defective platelet-fibrinogen interaction in thrombasthenia. Blood 1980; 55: 169-178.
    • (1980) Blood , vol.55 , pp. 169-178
    • Coller, B.S.1
  • 13
    • 0020619733 scopus 로고
    • A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins IIb and/or IIIa
    • Coller BS, Peerschke EI, Scudder LE, Sullivan CA. A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins IIb and/or IIIa. J Clin Invest 1983; 72: 325-338.
    • (1983) J Clin Invest , vol.72 , pp. 325-338
    • Coller, B.S.1    Peerschke, E.I.2    Scudder, L.E.3    Sullivan, C.A.4
  • 14
    • 0022312359 scopus 로고
    • Prenatal diagnosis of Glanzmann's thrombasthenia
    • Seligsohn U, Mibashan RS, Rodeck CH, et al. Prenatal diagnosis of Glanzmann's thrombasthenia. Lancet 1985; 2: 1419.
    • (1985) Lancet , vol.2 , pp. 1419
    • Seligsohn, U.1    Mibashan, R.S.2    Rodeck, C.H.3
  • 15
    • 0021965983 scopus 로고
    • A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet GPIIb/IIIa complex
    • Coller BS. A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet GPIIb/IIIa complex. J Clin Invest 1985; 76: 101-108.
    • (1985) J Clin Invest , vol.76 , pp. 101-108
    • Coller, B.S.1
  • 16
    • 0001356033 scopus 로고    scopus 로고
    • Preclinical development of c7E3 Fab, a mouse/human chimeric monoclonal antibody fragment that inhibits platelet function by blockade of GPIIb/IIIa receptors with observations on the immunogenicity of c7E3 Fab in humans
    • Horton MD, ed, Boca Raton, FL: CRC Press;
    • Jordan RE, Wagner CL, Mascelli M, et al. Preclinical development of c7E3 Fab, a mouse/human chimeric monoclonal antibody fragment that inhibits platelet function by blockade of GPIIb/IIIa receptors with observations on the immunogenicity of c7E3 Fab in humans. In: Horton MD, ed. Adhesion Receptors as Therapeutic Targets. Boca Raton, FL: CRC Press; 1996; 281-305.
    • (1996) Adhesion Receptors as Therapeutic Targets , pp. 281-305
    • Jordan, R.E.1    Wagner, C.L.2    Mascelli, M.3
  • 17
    • 38949130475 scopus 로고    scopus 로고
    • Application of high throughput screening to identify a novel aIIb-specific small molecule inhibitor of ℒIbβ3-mediated platelet interaction with fibrinogen
    • Blue R, Murcia M, Karan C, et al. Application of high throughput screening to identify a novel aIIb-specific small molecule inhibitor of ℒIbβ3-mediated platelet interaction with fibrinogen. Blood 2008; 111: 1248-1256.
    • (2008) Blood , vol.111 , pp. 1248-1256
    • Blue, R.1    Murcia, M.2    Karan, C.3
  • 18
    • 0001960590 scopus 로고    scopus 로고
    • Monitoring platelet GPIIb/IIIa antagonist therapy
    • Coller BS. Monitoring platelet GPIIb/IIIa antagonist therapy. Circulation 1998; 97: 5-9.
    • (1998) Circulation , vol.97 , pp. 5-9
    • Coller, B.S.1
  • 19
    • 0033537494 scopus 로고    scopus 로고
    • Rapid platelet-function assay (RPFA): An automated and quantitative cartridge-based method
    • Smith JW, Steinhubl SR, Lincoff AM, et al. Rapid platelet-function assay (RPFA): an automated and quantitative cartridge-based method. Circulation 1999; 99: 620-625.
    • (1999) Circulation , vol.99 , pp. 620-625
    • Smith, J.W.1    Steinhubl, S.R.2    Lincoff, A.M.3
  • 20
    • 0025033952 scopus 로고
    • Pharmacodynamic study of F(ab')2 fragments of murine monoclonal anti-body 7E3 directed against human platelet glycoprotein IIb/IIIa, in patients with unstable angina pectoris
    • Gold HK, Gimple L, Yasuda T, et al. Pharmacodynamic study of F(ab')2 fragments of murine monoclonal anti-body 7E3 directed against human platelet glycoprotein IIb/IIIa, in patients with unstable angina pectoris. J Clin Invest 1990; 86: 651-659.
    • (1990) J Clin Invest , vol.86 , pp. 651-659
    • Gold, H.K.1    Gimple, L.2    Yasuda, T.3
  • 21
    • 57149120289 scopus 로고    scopus 로고
    • Coller BS, Anderson K, Weisman HF. Inhibitors of platelet aggregation: GPIIb/IIIa antagonists. In: Braunwald E, ed. Heart Disease: A Textbook of Cardiovascular Medicine. Update 4. Philadelphia, PA: W.B. Saunders Co. 1995; 1-10.
    • Coller BS, Anderson K, Weisman HF. Inhibitors of platelet aggregation: GPIIb/IIIa antagonists. In: Braunwald E, ed. Heart Disease: A Textbook of Cardiovascular Medicine. Update 4. Philadelphia, PA: W.B. Saunders Co. 1995; 1-10.
  • 22
    • 2242477091 scopus 로고
    • Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty
    • EPIC Investigators
    • EPIC Investigators. Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty. N Engl J Med 1994; 330: 956-961.
    • (1994) N Engl J Med , vol.330 , pp. 956-961
  • 23
    • 0033152273 scopus 로고    scopus 로고
    • Abciximab facilitates the rate and extent of thrombolysis: Results of the thrombolysis in myocardial infarction (TIMI) 14 trial. The TIMI 14 Investigators
    • Antman EM, Giugliano RP, Gibson CM, et al. Abciximab facilitates the rate and extent of thrombolysis: results of the thrombolysis in myocardial infarction (TIMI) 14 trial. The TIMI 14 Investigators. Circulation 1999; 99: 2720-2732.
    • (1999) Circulation , vol.99 , pp. 2720-2732
    • Antman, E.M.1    Giugliano, R.P.2    Gibson, C.M.3
  • 25
    • 0037096263 scopus 로고    scopus 로고
    • Professing and living the oath: Teaching medicine as a profession
    • Coller BS, Klotman P, Smith LG. Professing and living the oath: teaching medicine as a profession. Am J Med 2002; 112: 744-748.
    • (2002) Am J Med , vol.112 , pp. 744-748
    • Coller, B.S.1    Klotman, P.2    Smith, L.G.3
  • 26
    • 57149102665 scopus 로고    scopus 로고
    • I swear, an oath for scientists and engineers, November 10
    • Mohan-Ram V. 'I swear...': an oath for scientists and engineers. Science November 10, 2000.
    • (2000) Science
    • Mohan-Ram, V.1
  • 27
    • 0242299684 scopus 로고    scopus 로고
    • An oath for bioscientists
    • Tsai DF, Chen DS. An oath for bioscientists. J Biomed Sci 2003; 10: 569-576.
    • (2003) J Biomed Sci , vol.10 , pp. 569-576
    • Tsai, D.F.1    Chen, D.S.2
  • 28
    • 84878745867 scopus 로고    scopus 로고
    • Student Pugwash USA, Available at:, Accessed July 2008
    • Student Pugwash USA. SPUSA pledge. Available at: http://www.spusa.org/ pledge. Accessed July 2008.
    • SPUSA pledge
  • 29
    • 57149089229 scopus 로고    scopus 로고
    • Available at:, Accessed July 2008
    • National Institutes of Health. Biomedical research workforce. Available at: http://grants.nih.gov/grants/new_investigators/ workforce_info09072007.ppt. Accessed July 2008.
    • Biomedical research workforce
  • 30
    • 57149096207 scopus 로고    scopus 로고
    • What is Pasteur? Available at: http://www.pasteur.harvard.edu. Accessed July 2008.
    • What is Pasteur? Available at: http://www.pasteur.harvard.edu. Accessed July 2008.
  • 31
    • 34948902357 scopus 로고    scopus 로고
    • Science education and communication: ANP presidential address
    • Ausiello D. Science education and communication: ANP presidential address. J Clin Invest 2007; 117: 3128-3130.
    • (2007) J Clin Invest , vol.117 , pp. 3128-3130
    • Ausiello, D.1
  • 32
    • 0004281462 scopus 로고
    • Cambridge, United Kingdom: Cambridge University Press;
    • Snow CP. The Two Cultures. Cambridge, United Kingdom: Cambridge University Press; 1993.
    • (1993) The Two Cultures
    • Snow, C.P.1


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