Macrophage fusion leading to foreign body giant cell formation persists under phagocytic stimulation by microspheres in vitro and in vivo in mouse models

Journal of Biomedical Materials Research - Part A

Volumn 93, Issue 1, 2010, Pages 189-199

  Jay, Steven M ^a,b   Skokos, Eleni A ^b,c   Zeng, Jianmin ^b,c   Knox, Kristin ^a   Kyriakides, Themis R ^a,b,c  

^a Yale University   (United States)

^b YALE UNIVERSITY   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Foreign body giant cell; Foreign body response; Inflammation; Macrophage fusion

Indexed keywords

BIOMATERIAL SURFACES; BONE MARROW; CELL LINES; EXPERIMENTAL EVIDENCE; FOREIGN BODY GIANT CELLS; FOREIGN BODY RESPONSE; IN-VITRO; IN-VIVO; INTRAPERITONEAL; LARGE SIZES; MOUSE MODELS; POLYSTYRENE MICRO-SPHERE; SURFACE ADHESION;

ANTIGEN-ANTIBODY REACTIONS; BIOLOGICAL MATERIALS; BIOMATERIALS; CELL CULTURE; CELLULAR MANUFACTURING; MICROSPHERES; PATHOLOGY; POLYSTYRENES;

MACROPHAGES;

BIOMATERIAL; MICROSPHERE; POLYSTYRENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CELL ADHESION; CELL FUSION; CELL STIMULATION; CONTROLLED STUDY; FOREIGN BODY; GIANT CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KINETICS; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PHAGOCYTE; PHAGOCYTOSIS;

ANIMALS; BIOCOMPATIBLE MATERIALS; CELL ADHESION; CELL FUSION; CELL LINE; ENZYME ACTIVATION; FOREIGN-BODY REACTION; GIANT CELLS, FOREIGN-BODY; HUMANS; INTERLEUKIN-4; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; MICROSPHERES; MONOCYTES; PHAGOCYTOSIS; POLYSTYRENES; PROSTHESIS IMPLANTATION; RAC1 GTP-BINDING PROTEIN;

EID: 77649204571     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32513     Document Type: Article

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