A cell permeant peptide containing the cytoplasmic tail sequence of Fc receptor type IIA reduces calcium signaling and phagolysosome formation in neutrophils

Cellular Immunology

Volumn 261, Issue 2, 2010, Pages 153-158

  Clark, Andrea J ^a   Petty, Howard R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Fc receptor; Human; Inflammation; Neutrophil; Phagocytosis; Rheumatoid arthritis

Indexed keywords

CALCIUM CHANNEL AFFECTING AGENT; TROJAN PEPTIDE FC RECEPTOR IIA CONJUGATE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; CYTOPLASM; DRUG MECHANISM; DRUG SCREENING; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; MEMBRANE FORMATION; NEUTROPHIL; NORMAL HUMAN; PHAGOLYSOSOME; PRIORITY JOURNAL; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM SIGNALING; CELL MEMBRANE PERMEABILITY; HUMANS; LYSOSOMES; MEMBRANE FUSION; MOLECULAR SEQUENCE DATA; NEUTROPHILS; PEPTIDES; PHAGOSOMES; RECEPTORS, IGG;

EID: 77649192924     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2009.12.002     Document Type: Article

References (32)

1. Ravetch J.V., Kinet J.P. Fc receptors. Annu. Rev. Immunol. 1991, 9:457-492.
2. Ivan E., Colovai A.I. Human Fc receptors: critical targets in the treatment of autoimmune diseases and transplant rejections. Hum. Immunol. 2006, 67:479-491.
3. Sardjono C.T., Mottram P.L., Hogarth P.M. The role of FcγRIIa as an inflammatory mediator in rheumatoid arthritis and systemic lupus erythematosus. Immunol. Cell Biol. 2003, 81:374-381.
4. Wijngaarden S., van Roon J.A., van de Winkel J.G., Bijlsma J.W., Lafeber F.P. Down-regulation of activating Fcγ receptors on monocytes of patients with rheumatoid arthritis upon methotrexate treatment. Rheumatology 2005, 44:729-734.
5. Wijngaarden S., van Roon J.A., Bijlsma J.W., van de Winkel J.G., Lafeber F.P. Fcγ receptor expression levels on monocytes are elevated in rheumatoid arthritis patients with high erythrocyte sedimentation rate who do not use anti-rheumatic drugs. Rheumatology 2003, 42:681-688.
6. Mathsson L., Lampa J., Mullazehi M., Ronnelid J. Immune complexes from rheumatoid arthritis synovial fluid induce FcγRlla dependent and rheumatoid factor correlated production of tumor necrosis factor-α by peripheral blood mononuclear cells. Arthritis Res. Ther. 2006, 8:R64.
7. Mullazehi M., Mathsson L., Lampa J., Ronnelid J. Surface-bound anti-type II collagen-containing immune complexes induce production of tumor necrosis factor α, interleukin-1β, and interleukin-8 from peripheral blood monocytes via Fcγ receptor IIa. Arthritis Rheum. 2006, 54:1759-1771.
8. Sardjono C.T., Mottram P.L., ven de Velde N.C., Powell M.S., Power D., Slocombe R.F., Wicks I.P., Campbell I.K., McKenzie S.E., Brooks M., Stevenson A.W., Hogarth P.M. Development of spontaneous multisystem autoimmune disease and hypersensitivity to antibody-induced inflammation in Fcγ receptor IIa-transgenic mice. Arthritis Rheum. 2005, 52:3220-3229.
9. van Lent P.L., Grevers L., Lubberts E., de Vries T.J., Nabbe K.C., Verbeek S., Oppers B., Sloetjes A., Blom A.B., van den Berg W.B. Fcγ receptors directly mediate cartilage, but not bone, destruction in murine antigen-induced arthritis: uncoupling of cartilage damage from bone erosion and joint inflammation. Arthritis Rheum. 2006, 54:3868-3877.
10. Boross P., van Lent P.L., Martin-Ramirez J., van der Kaa J., Mulder M.H., Claassens J.W., van den Berg W.B., Arandhara V.L., Verbeek J.S. Destructive arthritis in the absence of both FcγRI and FcγRIII. J. Immunol. 2008, 180:5083-5091.
11. Pietersz G.A., Mottram P.L., van de Velde N.C., Sardjono C.T., Esparon S., Ramsland P.A., Moloney G., Baell J.B., McCarthy T.D., Matthews B.R., Powell M.S., Hogarth P.M. Inhibition of destructive autoimmune arthritis in FcγRIIa transgenic mice by small chemical entities. Immunol. Cell Biol. 2009, 87:3-12.
12. Worth R.G., Mayo-Bond L., van de Winkel J.G., Todd R.F., Petty H.R., Schreiber A.D. The cytoplasmic domain of FcγRIIA (CD32) participates in phagolysosome formation. Blood 2001, 98:3429-3434.
13. Worth R.G., Kim M.K., Kindzelskii A.L., Petty H.R., Schreiber A.D. Signal sequence within FcγRIIA controls calcium wave propagation patterns: apparent role in phagolysosome fusion. Proc. Natl. Acad. Sci. USA 2003, 100:4533-4538.
14. Letourneur F., Klausner R.D. A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains. Cell 1992, 69:1143-1157.
15. Oehlke J., Scheller A., Wiesner B., Krause E., Beyermann M., Klauschenz E., Melzig M., Bienert M. Cellular uptake of an alpha-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically. Biochim. Biophys. Acta 1998, 1414:127-139.
16. Scheller A., Oehlke J., Wiesner B., Dathe M., Krause E., Beyermann M., Melzig M., Bienert M. Structural requirements for cellular uptake of alpha-helical amphipathic peptides. J. Pept. Sci. 1999, 5:185-194.
17. Derossi D., Chassaing G., Prochiantz A. Trojan peptides: the penetratin system for intracellular delivery. Trends Cell Biol. 1998, 8:84-87.
18. Lindgren M., Hallbrink M., Prochiantz A., Langel U. Cell-penetrating peptides. Trends Pharmacol. Sci. 2000, 21:99-103.
19. Schwarze S.R., Dowdy S.F. In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA. Trends Pharmacol. Sci. 2000, 21:45-48.
20. Hallbrink M., Floren A., Elmquist A., Pooga M., Bartfai T., Langel U. Cargo delivery kinetics of cell-penetrating peptides. Biochim. Biophys. Acta 2001, 1515:101-109.
21. Cole L., Davies D., Hyde G.J., Ashford A.E. ER-Tracker dye and BODIPY-brefeldin A differentiate the endoplasmic reticulum and golgi bodies from the tubular-vacuole system in living hyphae of Pisolithus tinctorius. J. Microsc. 2000, 197(Pt. 3):239-249.
22. Via L.E., Fratti R.A., McFalone M., Pagan-Ramos E., Deretic D., Deretic V. Effects of cytokines on mycobacterial phagosome maturation. J. Cell Sci. 1998, 111(Pt. 7):897-905.
23. Clark A.J., Petty H.R. Observation of calcium microdomains at the uropod of living morphologically polarized human neutrophils using flash lamp-based fluorescence microscopy. Cytometry A 2008, 73:673-678.
24. Hall H., Williams E.J., Moore S.E., Walsh F.S., Prochiantz A., Doherty P. Inhibition of FGF-stimulated phosphatidylinositol hydrolysis and neurite outgrowth by a cell-membrane permeable phosphopeptide. Curr. Biol. 1996, 6:580-587.
25. Williams E.J., Dunican D.J., Green P.J., Howell F.V., Derossi D., Walsh F.S., Doherty P. Selective inhibition of growth factor-stimulated mitogenesis by a cell-permeable Grb2-binding peptide. J. Biol. Chem. 1997, 272:22349-22354.
26. Cunningham C.C., Vegners R., Bucki R., Funaki M., Korde N., Hartwig J.H., Stossel T.P., Janmey P.A. Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J. Biol. Chem. 2001, 276:43390-43399.
27. Klopfenstein D.R., Kappeler F., Hauri H.P. A novel direct interaction of endoplasmic reticulum with microtubules. EMBO J. 1998, 17:6168-6177.
28. Muller-Taubenberger A., Lupas A.N., Li H., Ecke M., Simmeth E., Gerisch G. Calreticulin and calnexin in the endoplasmic reticulum are important for phagocytosis. EMBO J. 2001, 20:6772-6782.
29. Feske S. Calcium signalling in lymphocyte activation and disease. Nat. Rev. Immunol. 2007, 7:690-702.
30. Jaconi M.E., Lew D.P., Carpentier J.L., Magnusson K.E., Sjogren M., Stendahl O. Cytosolic free calcium elevation mediates the phagosome-lysosome fusion during phagocytosis in human neutrophils. J. Cell Biol. 1990, 110:1555-1564.
31. Marx V. Watching peptide drugs grow up. Chem. Eng. News 2005, 83:17-24.
32. Athanasou N.A., Quinn J. Immunocytochemical analysis of human synovial lining cells: phenotypic relation to other marrow derived cells. Ann. Rheum. Dis. 1991, 50:311-315.