O-GlcNAc inhibits interaction between Sp1 and sterol regulatory element binding protein 2

Biochemical and Biophysical Research Communications

Volumn 393, Issue 2, 2010, Pages 314-318

  Lim, Kihong ^a   Chang, Hyo Ihl ^a  

^a Korea University   (South Korea)

Author keywords

Acetyl CoA synthetase 1; O GlcNAc; Sp1; Sterol regulatory element binding protein 2

Indexed keywords

ACETYL COENZYME A; N ACETYLGLUCOSAMINE; O LINKED N ACETYLGLUCOSAMINE; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ARTICLE; ENZYME REGULATION; LIPOGENESIS; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

ACETYLGLUCOSAMINE; ANIMALS; CELL LINE; COENZYME A LIGASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LIPIDS; MICE; SP1 TRANSCRIPTION FACTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION, GENETIC;

EUKARYOTA;

EID: 77649189817     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.01.128     Document Type: Article

References (22)

1. Butkinaree C., Park K., and Hart G.W. O-linked beta-N-acetylglucosamine (O-GlcNAc): extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress. Biochim. Biophys. Acta 1800 (2009) 96-106
2. Jackson S.P., and Tjian R. O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulation. Cell 55 (1988) 125-133
3. Kelly W.G., and Hart G.W. Glycosylation of chromosomal proteins: localization of O-linked N-acetylglucosamine in Drosophila chromatin. Cell 57 (1989) 243-251
4. Yang X., Zhang F., and Kudlow J.E. Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcription repression. Cell 110 (2002) 69-80
5. Yang X., Su K., Roos M.D., Chang Q., and Kudlow J.E. O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability. Proc. Natl. Acad. Sci. USA 98 (2001) 6611-6616
6. Roos M.D., Su K., Baker J.R., and Kudlow J.E. O-glycosylation of a Sp1-derived peptide blocks known Sp1 protein interactions. Mol. Cell. Biol. 17 (1997) 6472-6480
7. Gambetta M.C., Oktaba K., and Muller J. Essential role of the glycosyltransferase Sxc/Ogt in Polycomb Repression. Science 325 (2009) 93-96
8. Wierstra I. Sp1: emerging roles - beyond constitutive activation of TATA-less housekeeping genes. Biochem. Biophys. Res. Commun. 372 (2008) 1-13
9. Lim K., and Chang H.I. O-GlcNAc modification of Sp1 inhibits the functional interaction between Sp1 and Oct1. FEBS Lett. 583 (2009) 512-520
10. Lim K., and Chang H.I. O-GlcNAc inhibits interaction between Sp1 and Elf-1 transcription factors. Biochem. Biophys. Res. Commun. 380 (2009) 569-574
11. Nathan L.-V., and Linda C.H.-W. Dynamic glycosylation of the transcription factor CREB: a potential role in gene regulation. J. Am. Chem. Soc. 125 (2003) 6612-6613
12. Yang W.H., Park S.Y., Nam H.W., Kim D.H., Kang J.G., Kang E.S., Kim Y.S., Lee H.C., Kim K.S., and Cho J.W. NFκB activation is associated with its O-GlcNAcylation state under hyperglycemic conditions. Proc. Natl. Acad. Sci. USA 105 (2008) 17345-17350
13. Edwards P.A., and Ericsson J. Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway. Annu. Rev. Biochem. 68 (1999) 157-185
14. Osborne T.F. Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action. J. Biol. Chem. 275 (2000) 32379-32382
15. Yieh L., Sanchez H.B., and Osborne T.F. Domains of transcription factor Sp1 required for synergistic activation with sterol regulatory element binding protein 1 of low density lipoprotein receptor promoter. Proc. Natl. Acad. Sci. USA 92 (1995) 6102-6106
16. Lim K.H., and Chang H.I. O-linked N-acetylglucosamine suppresses thermal aggregation of Sp1. FEBS Lett. 580 (2006) 4645-4652
17. Ikeda Y., Yamamoto J., Okamura M., Fujino T., Takahashi S., Takeuchi K., Osborne T.F., Yamamoto T.T., Ito S., and Sakai J. Transcriptional regulation of the murine Acetyl-CoA synthetase 1 gene through multiple clustered binding sites for sterol regulatory element-binding proteins and a single neighboring site for Sp1. J. Biol. Chem. 276 (2001) 34259-34269
18. Fujiki R., Chikanishi T., Hashiba W., Ito H., Takada I., Roeder R.G., Kitagawa H., and Kato S. GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. Nature 459 (2009) 455-459
19. Sinclaira D.A.R., Syrzyckaa M., Macauleyb M.S., Rastgardania T., Komljenovicc I., Vocadlob D.J., Brockc H.W., and Honda B.M. Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc). Proc. Natl. Acad. Sci. USA 106 (2009) 13427-13432
20. Ohn T., Kedersha N., Hickman T., Tisdale S., and Anderson P. A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assembly. Nat. Cell Biol. 10 (2008) 1224-1231
21. Yang X., Ongusaha P.P., Miles P.D., Havstad J.C., Zhang F., So W.V., Kudlow J.E., Michell R.H., Olefsky J.M., Field S.J., and Evans R.M. Phosphoinositide signaling links O-GlcNAc transferase to insulin resistance. Nature 451 (2008) 964-969
22. Lim K., and Chang H.I. O-GlcNAcylation of Sp1 interrupts Sp1 interaction with NF-Y. Biochem. Biophys. Res. Commun. 382 (2009) 593-597