Targeting extracellular signal-regulated kinase (ERK) signaling has therapeutic implications for inflammatory osteolysis

Bone

Volumn 46, Issue 3, 2010, Pages 695-702

  Seo, Sung Wook ^a,b   Lee, Daniel ^b   Minematsu, Hiroshi ^b   Kim, Abraham D ^b   Shin, Mike ^b   Cho, Samuel K ^b   Kim, Dae Won ^b   Yang, Jay ^c   Lee, Francis Y ^b  

^a Sungkyunkwan University   (South Korea)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Extracellular signal regulated kinase (ERK) signaling; Inflammatory osteolysis; Lipopolysaccharide (LPS); Macrophage colony stimulating factor (M CSF); Osteoblasts

Indexed keywords

COLONY STIMULATING FACTOR 1; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; 2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; AUTACOID; FLAVONOID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DISEASE; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY OSTEOLYSIS; INHIBITION KINETICS; INNATE IMMUNITY; MACROPHAGE; MALE; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOLYSIS; PROTEIN EXPRESSION; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL LINE; COMPARATIVE STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; DRUG THERAPY; ENZYMOLOGY; METABOLISM; PHYSIOLOGY; PROCEDURES;

ANIMALS; CELL LINE; DRUG DELIVERY SYSTEMS; FLAVONOIDS; INFLAMMATION MEDIATORS; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; OSTEOLYSIS;

EID: 77649183892     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.10.032     Document Type: Article

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