Nocturnal leg cramps

Current Neurology and Neuroscience Reports

Volumn 10, Issue 1, 2010, Pages 53-59

  Monderer, Renee S ^a   Wu, Winfred P ^a   Thorpy, Michael J ^a  

^a MONTEFIORE MEDICAL CENTER   (United States)

Author keywords

Diltiazem; Epidemiology; Exercises; Gabapentin; Magnesium; Nocturnal leg cramps; Pathophysiology; Quinine; Secondary causes; Verapamil; Vitamin B complex; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ALUMINUM HYDROXIDE; ANTICONVULSIVE AGENT; BOTULINUM TOXIN; CALCIUM CHANNEL BLOCKING AGENT; CIMETIDINE; DIGOXIN; DILTIAZEM; FURSULTIAMINE; GABAPENTIN; HEPARIN; HYDROXOCOBALAMIN; LIDOCAINE; MAGNESIUM SULFATE; NAFTIDROFURYL OXALATE; NIFEDIPINE; ORPHENADRINE CITRATE; PLACEBO; PYRIDOXAL 5 PHOSPHATE; QUININE SULFATE; RIBOFLAVIN; VERAPAMIL; VITAMIN B COMPLEX;

ABSENCE OF SIDE EFFECTS; ANGINA PECTORIS; CARDIOVASCULAR EFFECT; CLINICAL FEATURE; CLINICAL TRIAL; DIARRHEA; DIFFERENTIAL DIAGNOSIS; DISEASE DURATION; DROWSINESS; DRUG BLOOD LEVEL; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; DRUG POTENTIATION; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSTONIA; EPIGASTRIC PAIN; EVENING DOSAGE; HEMOLYTIC UREMIC SYNDROME; HUMAN; HYPERSENSITIVITY REACTION; IDIOPATHIC DISEASE; LEG CRAMP; LEUKOPENIA; LIVER GRANULOMA; MALARIA; MASSAGE; MUSCLE DISEASE; MYALGIA; NAUSEA; NERVE INJURY; NOCTURNAL LEG CRAMP; PATHOPHYSIOLOGY; PATIENT COMPLIANCE; PERIPHERAL NEUROPATHY; RESTLESS LEGS SYNDROME; REVIEW; RISK FACTOR; SIDE EFFECT; SLEEP DISORDER; SOMNOLENCE; STRETCHING EXERCISE; THROMBOCYTOPENIA; TINNITUS; UNSPECIFIED SIDE EFFECT; VISUAL IMPAIRMENT; VOMITING; WALKING;

HUMANS; RISK FACTORS; SLEEP-WAKE TRANSITION DISORDERS;

EID: 77649182093     PISSN: 15284042     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11910-009-0079-5     Document Type: Review

References (38)

1. JD Riley SJ Anthony 1995 Leg cramps: differential diagnosis and management Am Fam Physician 52 6 1794 1798 1:STN:280:DyaK28%2FkvV2msw%3D%3D 7484689
2. SK Oboler AV Prochazka TJ Meyer 1991 Leg symptoms in outpatient veterans West J Med 155 256 259 1:STN:280:DyaK38%2Fls1OitQ%3D%3D 1659038
3. JR Naylor JB Young 1994 A general population survey of rest cramps Age Ageing 23 5 418 420 10.1093/ageing/23.5.418 1:STN:280:DyaK2M7is1ShsA%3D%3D 7825490
4. Young GL, Jewell D: Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev 2002, 1:CD000121.
5. JG Hensley 2009 Leg cramps and restless legs syndrome during pregnancy J Midwifery Womens Health 54 3 211 218 10.1016/j.jmwh.2009.01.003 19410213 This article provides the most recent data on nocturnal leg cramps in pregnant women
6. AK Leung BE Wong PY Chan HY Cho 1999 Nocturnal leg cramps in children: incidence and clinical characteristics J Natl Med Assoc 91 329 332 1:STN:280:DyaK1MzhsVeisQ%3D%3D 10388258
7. Criggs RC: Episodic muscle spasms, cramps, and weakness. In Harrison's Principles of Internal Medicine, edn 14. Edited by Fauci AS, Braunwald E, Isselbaucher KJ, et al. New York: McGraw Hill International; 1998:119.
8. JV Butler EC Mulkerrin ST O'Keeffe 2002 Nocturnal leg cramps in older people Postgrad Med J 78 596 598 10.1136/pmj.78.924.596 1:STN:280: DC%2BD38nlsFaqsQ%3D%3D 12415081 (Pubitemid 35333065)
9. IH Weiner HL Weiner 1990 Nocturnal leg muscle cramps JAMA 150 511 518
10. SJ Sontag JN Wanner 1988 The cause of leg cramps and knee pains: a hypothesis and effective treatment Med Hypotheses 25 35 41 10.1016/0306-9877(88) 90044-8 1:STN:280:DyaL1c7kt1Khsg%3D%3D 3343944
11. JH Jacobsen RS Rosenberg PR Huttenlocher JP Spire 1986 Familial nocturnal cramping Sleep 9 54 60 1:STN:280:DyaL287nvFansg%3D%3D 3961367
12. S Chiba M Saitoh Y Hatanaka, et al. 1999 Autosomal dominant muscle cramp syndrome in a Japanese family J Neurol Neurosurg Psychiatry 67 116 119 10.1136/jnnp.67.1.116 1:STN:280:DyaK1M3pvFCgsw%3D%3D 10369837
13. American Academy of Sleep Medicine: Sleep related leg cramps. In The International Classification of Sleep Disorders, edn 2. Diagnostic and Coding Manual. Westchester, IL: American Academy of Sleep Medicine; 2005.
14. N Kannan R Sawaya 2001 Nocturnal leg cramps: clinically mysterious and painful-but manageable Geriatrics 56 6 34 42
15. M Man-Son-Hing G Wells 1995 Meta-analysis of efficacy of quinine for treatment of nocturnal leg cramps in elderly people BMJ 310 13 17 1:STN:280:DyaK2M7ivVahtg%3D%3D 7827545
16. M Man-Son-Hing G Wells A Lau 1998 Quinine for nocturnal leg cramps: a meta-analysis including unpublished data J Gen Intern Med 13 600 606 10.1046/j.1525-1497.1998.00182.x 1:STN:280:DyaK1cvisFCrtA%3D%3D 9754515 (Pubitemid 28424031)
17. HW Daniell 1979 Simple cure for nocturnal leg cramps N Eng J Med 301 216 1:STN:280:DyaE1M7pvFGhuw%3D%3D
18. RJ Coppin DM Wicke PS Little 2005 Managing nocturnal leg cramps-calf stretching exercises and cessation of quinine treatment: a factorial randomised controlled trial Br J Gen Pract 55 186 191 15808033
19. HC Diener U Dethlefsen S Dethlefsen-Gruber, et al. 2002 Effectiveness of quinine in treating muscle cramps: a double-blind, placebo-controlled, parallel-group, multicentre trial Int J Clin Pract 56 4 243 246 1:CAS:528:DC%2BD38Xlt1Cmsbk%3D 12074203
20. R Woodfield F Goodyear-Smith B Arroll 2005 N-of-1 trials of quinine efficacy in skeletal muscle cramps of the leg Br J Gen Pract 55 512 181 185 15808032 This is the most recent study looking at the efficacy of quinine in the treatment of leg cramps
21. TR Halfdanarson A Sigfusson V Haraldsdottir, et al. 2002 Severe adverse effects of quinine: report of seven cases Laeknabladid 88 10 717 722 16940621
22. AK Mandal T Abernathy SN Nelluri, et al. 1995 Is quinine effective and safe in leg cramps? J Clin Pharmacol 35 588 593 1:STN:280:DyaK2MzpsFSrsw%3D%3D 7665718
23. LO Dahle G Berg M Hammer, et al. 1995 The effect of oral magnesium substitution on pregnancy-induced leg cramps Am J Obstet Gynecol 173 175 180 10.1016/0002-9378(95)90186-8 1:STN:280:DyaK2MzlvVWqsw%3D%3D 7631676
24. R Frusso M Zarate F Augustovski, et al. 1999 Magnesium for the treatment of nocturnal leg cramps: a crossover randomized trial J Fam Pract 48 868 871 1:STN:280:DC%2BD3czoslGqsg%3D%3D 10907623
25. Roffe C, Sills S, Crome P, et al.: Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps. Med Sci Monit 2002, 8(5):CR326-CR330.
26. N Baltodano BV Gallo DJ Weidler 1988 Verapamil vs quinine in recumbent nocturnal leg cramps in the elderly Arch Intern Med 148 1969 1970 10.1001/archinte.148.9.1969 1:STN:280:DyaL1czisFOmsg%3D%3D 3046538 (Pubitemid 18211035)
27. WC Voon SH Sheu 2001 Diltiazem for nocturnal leg cramps [letter] Age Ageing 3 1 91 92 10.1093/ageing/30.1.91 (Pubitemid 32288247)
28. S Ayers Jr R Mihan 1969 Leg cramps (systremma) and "restless legs" syndrome. Response to vitamin E (tocopherol) Calif Med 111 87 91
29. AO Roca D Jarjoura D Blend, et al. 1992 Dialysis leg cramps. Efficacy of quinine versus vitamin E ASAIO J 38 481 485 10.1097/00002480-199207000-00081
30. PS Connolly EA Shirley JH Wasson, et al. 1992 Treatment of nocturnal leg cramps. A crossover trial of quinine vs vitamin E Arch Intern Med 152 9 1877 1880 10.1001/archinte.152.9.1877 1:STN:280:DyaK38zpt1Shtg%3D%3D 1520054
31. P Chan TY Huang YJ Chen, et al. 1998 Randomized, double-blind, placebo-controlled study of the safety and efficacy of vitamin B complex in the treatment of nocturnal leg cramps in the elderly patient with hypertension J Clin Pharmacol 38 12 1151 1154 1:CAS:528:DyaK1MXkt1Wiuw%3D%3D 11301568
32. JB Young MJ Connolly 1993 Naftidrofuryl treatment of rest cramps Postgrad Med J 69 624 626 10.1136/pgmj.69.814.624 1:STN:280:DyaK2c%2FltF2htQ%3D%3D 8234106
33. D Latta E Turner 1989 An alternative to quinine in nocturnal leg cramps Curr Ther Res 45 833 837
34. YJ Chang CL Wu RS Chen, et al. 1993 Case of Isaacs syndrome successfully treated with phenytoin J Formos Med Assoc 92 11 1010 1012 1:STN:280: DyaK2c3js1Sisg%3D%3D 7910059
35. ME Mueller M Gruenthal WL Olson, et al. 1997 Gabapentin for relief of upper motor neuron symptoms in multiple sclerosis Arch Phys Med Rehabil 78 5 521 524 10.1016/S0003-9993(97)90168-4 1:STN:280:DyaK2szgsFSqug%3D%3D 9161373 (Pubitemid 27212460)
36. M Serrao P Rossi P Cardinali, et al. 2000 Gabapentin treatment for muscle cramps: an open-label trial Clin Neuropharmacol 23 1 45 49 10.1097/00002826- 200001000-00008 1:CAS:528:DC%2BD3cXht1aqs7Y%3D 10682230 (Pubitemid 30090411)
37. P Prateepavanich V Kupniratsaikul T Charoensak 1999 The relationship between myofascial trigger points of gastrocnemius muscle and nocturnal calf cramps J Med Assoc Thai 82 451 459 1:STN:280:DyaK1Mznt1Snsw%3D%3D 10443094
38. L Bertolasi A Priori G Tomelleri, et al. 1997 Botulinum toxin treatment of muscle cramps: a clinical and neurophysiological study Ann Neurol 41 181 186 10.1002/ana.410410209 1:CAS:528:DyaK2sXhvVeksLg%3D 9029067 (Pubitemid 27082099)