Ubiquitous overexpression of Hey1 transcription factor leads to osteopenia and chondrocyte hypertrophy in bone

Bone

Volumn 46, Issue 3, 2010, Pages 680-694

  Salie, Rishard ^a   Kneissel, Michaela ^a   Vukevic, Mirko ^a   Zamurovic, Natasa ^a   Kramer, Ina ^a   Evans, Glenda ^a   Gerwin, Nicole ^a   Mueller, Matthias ^a   Kinzel, Bernd ^a   Susa, Mira ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Chondrocyte hypertrophy; HES; Hey1; Osteoblast; Osteoclast; Osteopenia

Indexed keywords

COLLAGEN TYPE 10; MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HEY1; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; GROWTH INHIBITOR; HEY1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MASS; CARTILAGE CELL; CHONDROPATHY; CONTROLLED STUDY; EX VIVO STUDY; FEMALE; GENE OVEREXPRESSION; HYPERTROPHY; IN VIVO STUDY; MALE; MOUSE; NEWBORN; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOPENIA; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEX DIFFERENCE; TRANSGENIC MOUSE; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; COMPARATIVE STUDY; DOMINANT GENE; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLIC BONE DISEASE; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; ANIMALS, NEWBORN; BONE DISEASES, METABOLIC; CELL CYCLE PROTEINS; CELLS, CULTURED; CHONDROCYTES; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, DOMINANT; GROWTH INHIBITORS; HYPERTROPHY; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; OSTEOBLASTS; OSTEOCLASTS; TRANSCRIPTION FACTORS;

EID: 77649179437     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.10.022     Document Type: Article

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