Electrical activation of the orbicularis oculi muscle does not increase the effectiveness of botulinum toxin type A in patients with blepharospasm

European Journal of Neurology

Volumn 17, Issue 3, 2010, Pages 449-455

  Conte, A ^a,b   Fabbrini, G ^a,b   Belvisi, D ^a   Marsili, L ^a   Di Stasio, F ^a   Berardelli, A ^a,b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Blepharospasm; Botulinum toxin; Muscle activation; Safety

Indexed keywords

BOTULINUM TOXIN A;

AGED; ARTICLE; BLEPHAROSPASM; BRAIN STEM; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ELECTROMYOGRAM; ELECTROPHYSIOLOGY; ELECTROSTIMULATION; EXCITABILITY; EYELID REFLEX; FEMALE; HUMAN; MALE; MUSCLE ACTION POTENTIAL; NEUROPHYSIOLOGY; ORBICULARIS OCULI MUSCLE; PRIORITY JOURNAL;

ACTION POTENTIALS; AGED; ANALYSIS OF VARIANCE; BLEPHAROSPASM; BLINKING; BOTULINUM TOXIN TYPE A; ELECTRIC STIMULATION THERAPY; ELECTROMYOGRAPHY; FACIAL NERVE; FEMALE; HUMANS; MALE; NEUROMUSCULAR AGENTS; OCULOMOTOR MUSCLES; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TREATMENT OUTCOME;

EID: 77649169645     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2009.02840.x     Document Type: Article

References (21)

1. Hughes R, Walker BC. Influence of nerve-ending activity and of drugs on the rate of paralysis of rat diaphragm preparations by clostridium botulinum toxin type A. J Physiol 1962 160 : 221 233.
2. Simpson LL. Kinetic studies on the interaction between botulinum toxin type A and the cholinergic neuromuscular junction. J Pharmacol Exp Ther 1980 212 : 16 21.
3. Gardiner PF, Michel R, Iadeluca G. Previous exercise training influences functional sprouting of rat hindlimb motoneurones in response to partial denervation. Neurosci Lett 1984 45 : 123 127.
4. Black JD, Dolly JO. Interaction of 125I-labeled botulinum neurotoxins with nerve terminals. II. Autoradiographic evidence for its uptake into motor nerves by acceptor-mediated endocytosis. J Cell Biol 1986 103 : 535 544.
5. Kim HS, Hwang JH, Jeong ST, et al. Effect of muscle activity and botulinum toxin dilution volume on muscle paralysis. Dev Med Child Neurol 2003 45 : 200 206.
6. Dong M, Yeh F, Tepp WH, et al. SV2 is the protein receptor for botulinum neurotoxin A. Science 2006 312 : 592 596.
7. Chen R, Karp BI, Goldstein SR, Bara-Jimenez W, Yassen Z, Hallett M. Effect of muscle activity immediately after botulinum toxin injection for writer's cramp. Mov Disord 1999 14 : 307 312.
8. Eleopra R, Tugnoli V, De Grandis D. The variability in the clinical effect induced by botulinum toxin type A: the role of muscle activity in humans. Mov Disord 1997 12 : 89 94.
9. Hesse S, Jahnke MT, Luecke D, Mauritz KH. Short-term electrical stimulation enhances the effectiveness of botulinum toxin in the treatment of lower limb spasticity in hemiparetic patients. Neurosci Lett 1995 201 : 37 40.
10. Frasson E, Priori A, Ruzzante B, Didonè G, Bertolasi L. Nerve stimulation boosts botulinum toxin action in spasticity. Mov Disord 2005 20 : 624 629.
11. Valls-Sole J, Tolosa ES, Ribera G. Neurophysiological observations on the effects of botulinum toxin treatment in patients with dystonic blepharospasm. J Neurol Neurosurg Psychiatry 1991 54 : 310 313.
12. Antonucci F, Rossi C, Gianfranceschi L, Rossetto O, Caleo M. Long-distance retrograde effects of botulinum neurotoxin A. J Neurosci 2008 28 : 3689 3696.
13. Brin MF, Jankovic J, Comella C, et al. Treatment of dystonia using botulinum toxin. In : Kurlan R, eds. Treatment of Movement Disorders. JB Lippincott Company : Lippincott, 1995 : 183 230.
14. Gittins J, Martin K, Sheldrick J, Reddy A, Thean L. Electrical stimulation as a therapeutic option to improve eyelid function in chronic facial nerve disorders. Invest Ophthalmol Vis Sci 1999 40 : 547 554.
15. Wirtschafter JD, Lander T, Baker RH, Stevanoviç M, Kirsch J, McLoon LK. Heterogeneous length and in-series arrangement of orbicularis oculi muscle: individual myofibers do not extend the length of the eyelid. Trans Am Ophthalmol Soc 1994 92 : 71 88.
16. Rha DW, Yang EJ, Chung HI, Kim HB, Park CI, Park ES. Is electrical stimulation beneficial for improving the paralytic effect of botulinum toxin type A in children with spastic diplegic cerebral palsy? Yonsei Med J 2008 49 : 545 552.
17. Currà A, Trompetto C, Abbruzzese G, Berardelli A. Central effects of botulinum toxin type A: evidence and supposition. Mov Disord 2004 19 (Suppl. 8 S60 S64.
18. Currà A, Berardelli A. Do the unintended actions of botulinum toxin at distant sites have clinical implications? Neurology 2009 72 : 1095 1099.
19. Berardelli A, Cruccu G, Manfredi M, Rothwell JC, Day BL, Marsden CD. The corneal reflex and the R2 component of the blink reflex. Neurology 1985 35 : 797 801.
20. Berardelli A, Rothwell JC, Day BL, Marsden CD. Pathophysiology of blepharospasm and oromandibular dystonia. Brain 1985 108 : 593 608.
21. Girlanda P, Quartarone A, Sinicropi S, Nicolosi C, Messina C. Unilateral injection of botulinum toxin in blepharospasm: single fiber electromyography and blink reflex study. Mov Disord 1996 11 : 27 31.