Synthesis, biophysical properties and pharmacokinetics of ultrahigh molecular weight tense and relaxed state polymerized bovine hemoglobins

Biomaterials

Volumn 31, Issue 13, 2010, Pages 3723-3735

  Buehler, Paul W ^a   Zhou, Yipin ^b   Cabrales, Pedro ^c   Jia, Yiping ^a   Sun, Guoyong ^b   Harris, David R ^b   Tsai, Amy G ^d   Intaglietta, Marcos ^d   Palmer, Andre F ^b  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b Ohio State University   (United States)

^c LA JOLLA BIOENGINEERING INSTITUTE   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Blood substitute; Hemoglobin; Oxygen carrier; Polymerized hemoglobin; Red blood cell; Transfusion

Indexed keywords

BIOPHYSICAL PROPERTIES; BOVINE HEMOGLOBIN; COMMERCIAL DEVELOPMENT; EXPOSURE-TIME; GUINEA PIGS; HEMOGLOBIN-BASED OXYGEN CARRIERS; HUMAN SERUM ALBUMINS; IN-VITRO; IN-VIVO; LATE STAGE; OSMOTIC PRESSURE; OXIDATIVE PROCESS; OXYGEN CARRIER; POLYMERIZATION REACTION; RED BLOOD CELL; RED BLOOD CELL TRANSFUSION; RELAXED STATE; TRANSFUSION MEDICINES; ULTRA-HIGH MOLECULAR WEIGHT;

ASSOCIATION REACTIONS; BLOOD SUBSTITUTES; CELLS; GLUCOSE; HEMOGLOBIN; HEMOGLOBIN OXYGEN SATURATION; MERCURY (METAL); MOLECULAR WEIGHT; OXYGEN; SOFTWARE ARCHITECTURE; SYNTHESIS (CHEMICAL);

BLOOD;

CARBON MONOXIDE; DEXTRAN; HEMOGLOBIN; HUMAN SERUM ALBUMIN; NITRIC OXIDE; OXYGEN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; AUTOOXIDATION; BIOPHYSICS; BLOOD TRANSFUSION; COLLOID; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG OXIDATION; DRUG SYNTHESIS; ERYTHROCYTE AGGREGATION; EXCHANGE BLOOD TRANSFUSION; GUINEA PIG; IN VITRO STUDY; MALE; MEAN RESIDENCE TIME; MOLECULAR WEIGHT; NONHUMAN; OSMOTIC PRESSURE; OXYGEN DISSOCIATION CURVE; POLYMERIZATION; PRIORITY JOURNAL; VISCOSITY;

ANIMALS; BIOPHYSICS; BIOPOLYMERS; CATTLE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ERYTHROCYTE AGGREGATION; HEMOGLOBINS; MOLECULAR WEIGHT; SOLUTIONS;

BOVINAE; CAVIA;

EID: 77549087739     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.01.072     Document Type: Article

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