Protamine reduces bleeding complications associated with carotid endarterectomy without increasing the risk of stroke

Journal of Vascular Surgery

Volumn 51, Issue 3, 2010, Pages

  Stone, David H ^a   Nolan, Brian W ^a,b   Schanzer, Andres ^c   Goodney, Philip P ^a   Cambria, Robert A ^d   Likosky, Donald S ^b   Walsh, Daniel B ^a   Cronenwett, Jack L ^a  

^a DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^b DARTMOUTH INSTITUTE FOR HEALTH POLICY AND CLINICAL PRACTICE   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d EASTERN MAINE MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBOCYTIC AGENT; HEPARIN; HYPERTENSIVE AGENT; PROTAMINE;

AGED; ANTICOAGULATION; ARTICLE; BLEEDING; CAROTID ENDARTERECTOMY; CONTROLLED STUDY; CRANIAL NERVE INJURY; DEATH; DISEASE REGISTRY; DRUG EFFECT; DRUG USE; FEMALE; GENERAL ANESTHESIA; HEART INFARCTION; HUMAN; HYPOTENSION; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; PATCH ANGIOPLASTY; PEROPERATIVE CARE; POSTOPERATIVE COMPLICATION; POSTOPERATIVE HEMORRHAGE; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; REOPERATION; RISK; SHUNTING; STROKE; SURGICAL TECHNIQUE; SUSAC SYNDROME; THROMBOSIS; TREATMENT OUTCOME;

EID: 77549085704     PISSN: 07415214     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jvs.2009.10.078     Document Type: Article

References (21)

1. Riles T.S., Imparato A.M., Jacobowitz G.R., Lamparello P.J., Giangola G., Adelman M.A., and Landis R. The cause of perioperative stroke after carotid endarterectomy. J Vasc Surg 19 (1994) 206-214 discussion 215-6
2. Weber C.F., Friedl H., Hueppe M., Hintereder G., Schmitz-Rixen T., Zwissler B., and Meininger D. Impact of general versus local anesthesia on early postoperative cognitive dysfunction following carotid endarterectomy: GALA Study Subgroup Analysis. World J Surg 33 (2009) 1526-1532
3. Lutz H.J., Michael R., Gahl B., and Savolainen H. Local versus general anaesthesia for carotid endarterectomy-improving the gold standard?. Eur J Vasc Endovasc Surg 36 (2008) 145-149 disussion 150-1
4. AbuRahma A.F., Stone P.A., Elmore M., Flaherty S.K., Armistead L., and AbuRahma Z. Prospective randomized trial of ACUSEAL (Gore-Tex) vs Finesse (Hemashield) patching during carotid endarterectomy: long-term outcome. J Vasc Surg 48 (2008) 99-103
5. Naylor R., Hayes P.D., Payne D.A., Allroggen H., Steel S., Thompson M.M., et al. Randomized trial of vein versus dacron patching during carotid endarterectomy: long-term results. J Vasc Surg 39 (2004) 985-993 discussion 993
6. Cao P., Giordano G., De Rango P., Zannetti S., Chiesa R., Coppi G., et al. Eversion versus conventional carotid endarterectomy: late results of a prospective multicenter randomized trial. J Vasc Surg 31 1 Pt 1 (2000) 19-30
7. Hans S.S., and Jareunpoon O. Prospective evaluation of electroencephalography, carotid artery stump pressure, and neurologic changes during 314 consecutive carotid endarterectomies performed in awake patients. J Vasc Surg 45 (2007) 511-515
8. Dellagrammaticas D., Lewis S.C., and Gough M.J. Is heparin reversal with protamine after carotid endarterectomy dangerous?. Eur J Vasc Endovasc Surg 36 (2008) 41-44
9. Levison J.A., Faust G.R., Halpern V.J., Theodoris A., Nathan I., Kline R.G., and Cohen J.R. Relationship of protamine dosing with postoperative complications of carotid endarterectomy. Ann Vasc Surg 13 (1999) 67-72
10. Treiman R.L., Cossman D.V., Foran R.F., Levin P.M., Cohen J.L., and Wagner W.H. The influence of neutralizing heparin after carotid endarterectomy on postoperative stroke and wound hematoma. J Vasc Surg 12 (1990) 440-445 discussion 445-6
11. Nybo M., and Madsen J.S. Serious anaphylactic reactions due to protamine sulfate: a systematic literature review. Basic Clin Pharmacol Toxicol 103 (2008) 192-196
12. Fearn S.J., Parry A.D., Picton A.J., Mortimer A.J., and McCollum C.N. Should heparin be reversed after carotid endarterectomy?. A randomised prospective trial. Eur J Vasc Endovasc Surg 13 (1997) 394-397
13. Mauney M.C., Buchanan S.A., Lawrence W.A., Bishop A., Sinclair K., Daniel T.M., et al. Stroke rate is markedly reduced after carotid endarterectomy by avoidance of protamine. J Vasc Surg 22 (1995) 264-269 discussion 269-70
14. Goodney P.P., Likosky D.S., and Cronenwett J.L. Factors associated with stroke or death after carotid endarterectomy in Northern New England. J Vasc Surg 48 (2008) 1139-1145
15. Cronenwett J.L., Likosky D.S., Russell M.T., Eldrup-Jorgensen J., Stanley A.C., and Nolan B.W. A regional registry for quality assurance and improvement: the Vascular Study Group of Northern New England (VSGNNE). J Vasc Surg 46 (2007) 1093-1101 discussion 1101-2
16. LaMuraglia G.M., Brewster D.C., Moncure A.C., Dorer D.J., Stoner M.C., Trehan S.K., et al. Carotid endarterectomy at the millennium: what interventional therapy must match. Ann Surg 240 (2004) 535-544 discussion 544-6
17. Engelter S., and Lyrer P. Antiplatelet therapy for preventing stroke and other vascular events after carotid endarterectomy. Cochrane Database Syst Rev 3 (2003) CD001458
18. Hamada Y., Kameyama Y., Narita H., Benson K.T., and Goto H. Protamine after heparin produces hypotension resulting from decreased sympathetic outflow secondary to increased nitric oxide in the central nervous system. Anesth Analg 100 (2005) 33-37
19. Welsby I.J., Newman M.F., Phillips-Bute B., Messier R.H., Kakkis E.D., and Stafford-Smith M. Hemodynamic changes after protamine administration: association with mortality after coronary artery bypass surgery. Anesthesiology 102 (2005) 308-314
20. Pretorius M., Scholl F.G., McFarlane J.A., Murphey L.J., and Brown N.J. A pilot study indicating that bradykinin B2 receptor antagonism attenuates protamine-related hypotension after cardiopulmonary bypass. Clin Pharmacol Ther 78 (2005) 477-485
21. Kudoh O., Warabi K., Yamaguchi K., Ichinose M., Iizuka T., and Inada E. [A case of anaphylactic shock in an elderly man following protamine sulfate administration during emergent off-pump coronary artery bypass grafting]. Masui 55 (2006) 605-610