A pilot study indicating that bradykinin B2 receptor antagonism attenuates protamine-related hypotension after cardiopulmonary bypass

Clinical Pharmacology and Therapeutics

Volumn 78, Issue 5, 2005, Pages 477-485

  Pretorius, Mias ^a   Scholl, Frank G ^b   McFarlane, Julie A ^b   Murphey, Laine J ^b   Brown, Nancy J ^b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BRADYKININ; BRADYKININ B2 RECEPTOR; BRADYKININ B2 RECEPTOR ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ICATIBANT; PROTAMINE; SODIUM CHLORIDE; TISSUE PLASMINOGEN ACTIVATOR;

ADULT; ARTICLE; BLOOD CLOTTING; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ELECTIVE SURGERY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HYPOTENSION; MALE; MEAN ARTERIAL PRESSURE; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL;

AGED; BRADYKININ; CARDIOPULMONARY BYPASS; DOUBLE-BLIND METHOD; FEMALE; FIBRINOLYSIS; HEMODYNAMIC PROCESSES; HEPARIN ANTAGONISTS; HUMANS; HYPOTENSION; KININS; MALE; MIDDLE AGED; PILOT PROJECTS; POSTOPERATIVE COMPLICATIONS; PROTAMINES; RECEPTOR, BRADYKININ B2;

EID: 28144460256     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clpt.2005.08.010     Document Type: Article

References (43)

1. F. Unger, P. Ghosh International cardiac surgery Semin Thorac Cardiovasc Surg 14 2002 321 323
2. J.A. Carr, N. Silverman The heparin-protamine interaction. A review J Cardiovasc Surg (Torino) 40 1999 659 666
3. S.E. Kimmel, M. Sekeres, J.A. Berlin, N. Ellison Mortality and adverse events after protamine administration in patients undergoing cardiopulmonary bypass Anesth Analg 94 2002 1402 1408
4. T. Oguchi, M.F. Doursout, S. Kashimoto, Y.Y. Liang, C.J. Hartley, J.E. Chelly Role of heparin and nitric oxide in the cardiac and regional hemodynamic properties of protamine in conscious chronically instrumented dogs Anesthesiology 94 2001 1016 1025
5. G.V. Raikar, K. Hisamochi, B.L. Raikar, H.V. Schaff Nitric oxide inhibition attenuates systemic hypotension produced by protamine J Thorac Cardiovasc Surg 111 1996 1240 1246
6. F. Viaro, M.B. Dalio, P.R. Evora Catastrophic cardiovascular adverse reactions to protamine are nitric oxide/cyclic guanosine monophosphate dependent and endothelium mediated should methylene blue be the treatment of choice? Chest 122 2002 1061 1066
7. P.J. Pearson, P.R. Evora, K. Ayrancioglu, H.V. Schaff Protamine releases endothelium-derived relaxing factor from systemic arteries. A possible mechanism of hypotension during heparin neutralization Circulation 86 1992 289 294
8. B.J. Hunt, R.N. Parratt, H.C. Segal, S. Sheikh, P. Kallis, M. Yacoub Activation of coagulation and fibrinolysis during cardiothoracic operations Ann Thorac Surg 65 1998 712 718
9. A. Koster, T. Fischer, M. Praus, H. Haberzettl, W.M. Kuebler, R. Hetzer Hemostatic activation and inflammatory response during cardiopulmonary bypass impact of heparin management Anesthesiology 97 2002 837 841
10. H.P. Wendel, D.W. Jones, M.J. Gallimore FXII levels, FXIIa-like activities and kallikrein activities in normal subjects and patients undergoing cardiac surgery Immunopharmacology 45 1999 141 144
11. A. Agostoni, M. Cugno, A. Agostini Influence of contact system deficiencies during cardiopulmonary bypass Thromb Haemost 85 2001 191 192
12. E.G. Erdos Kinins, the long march - a personal view Cardiovasc Res 54 2002 485 491
13. P.M. Vanhoutte Endothelium and control of vascular function state of the art lecture Hypertension 13 1989 658 667
14. 2 receptor-dependent, NO synthase-independent, and cyclooxygenase-independent pathway Circulation 102 2000 2190 2196
15. M. Cugno, J. Nussberger, P. Biglioli, M.G. Giovagnoni, M. Gardinali, A. Agostoni Cardiopulmonary bypass increases plasma bradykinin concentrations Immunopharmacology 43 1999 145 147
16. D.J. Campbell, B. Dixon, A. Kladis, M. Kemme, J.D. Santamaria Activation of the kallikrein-kinin system by cardiopulmonary bypass in humans Am J Physiol Regul Integr Comp Physiol 281 2001 R1059 R1070
17. M. Pretorius, J.A. McFarlane, D.E. Vaughan, N.J. Brown, L.J. Murphey Angiotensin-converting enzyme inhibition and smoking potentiate the kinin response to cardiopulmonary bypass Clin Pharmacol Ther 76 2004 379 387
18. A. DeLucia III, T.W. Wakefield, P.C. Andrews, B.J. Nichol, A.M. Kadell, S.K. Wrobleski Efficacy and toxicity of differently charged polycationic protamine-like peptides for heparin anticoagulation reversal J Vasc Surg 18 1993 49 58 discussion 58-60
19. I. Bjork, S.T. Olson, R.G. Sheffer, J.D. Shore Binding of heparin to human high molecular weight kininogen Biochemistry 28 1989 1213 1221
20. F. Tan, H. Jackman, R.A. Skidgel, E.K. Zsigmond, E.G. Erdos Protamine inhibits plasma carboxypeptidase N, the inactivator of anaphylatoxins and kinins Anesthesiology 70 1989 267 275
21. J.R. Cockcroft, P.J. Chowienczyk, S.E. Brett, N. Bender, J.M. Ritter Inhibition of bradykinin-induced vasodilation in human forearm vasculature by icatibant, a potent B2-receptor antagonist Br J Clin Pharmacol 38 1994 317 321
22. H.A. Seifert, D.R. Jobes, T. Ten Have, S.E. Kimmel, L.M. Montenegro, J.M. Steven Adverse events after protamine administration following cardiopulmonary bypass in infants and children Anesth Analg 97 2003 383 389
23. S.E. Kimmel, M.A. Sekeres, J.A. Berlin, N. Ellison, V.J. DiSesa, B.L. Strom Risk factors for clinically important adverse events after protamine administration following cardiopulmonary bypass J Am Coll Cardiol 32 1998 1916 1922
24. I.J. Welsby, M.F. Newman, B. Phillips-Bute, R.H. Messier, E.D. Kakkis, M. Stafford-Smith Hemodynamic changes after protamine administration association with mortality after coronary artery bypass surgery Anesthesiology 102 2005 308 314
25. M. Tramontana, A. Lecci, S. Meini, X. Montserrat, J. Pascual, S. Giuliani Differences between peptide and nonpeptide B(2) bradykinin receptor antagonists in blocking bronchoconstriction and hypotension induced by bradykinin in anesthetized Guinea pigs J Pharmacol Exp Ther 296 2001 1051 1057
26. J.V. Gainer, J.D. Morrow, A. Loveland, D.J. King, N.J. Brown Effect of bradykinin-receptor blockade on the response to angiotensin-converting-enzyme inhibitor in normotensive and hypertensive subjects N Engl J Med 339 1998 1285 1292
27. M. Pretorius, D. Rosenbaum, D.E. Vaughan, N.J. Brown Angiotensin- converting enzyme inhibition increases human vascular tissue-type plasminogen activator release through endogenous bradykinin Circulation 107 2003 579 585
28. I.B. Squire, K.P. O'Kane, N. Anderson, J.L. Reid Bradykinin B(2) receptor antagonism attenuates blood pressure response to acute angiotensin-converting enzyme inhibition in normal men Hypertension 36 2000 132 136
29. N.L. Cruden, F.N. Witherow, D.J. Webb, K.A. Fox, D.E. Newby Bradykinin contributes to the systemic hemodynamic effects of chronic angiotensin- converting enzyme inhibition in patients with heart failure Arterioscler Thromb Vasc Biol 24 2004 1043 1048
30. R. Hammermann, J. Hirschmann, C. Hey, J. Mossner, G. Folkerts, F.P. Nijkamp Cationic proteins inhibit L-arginine uptake in rat alveolar macrophages and tracheal epithelial cells. Implications for nitric oxide synthesis Am J Respir Cell Mol Biol 21 1999 155 162
31. M. Cyr, Y. Lepage, C. Blais Jr, N. Gervais, M. Cugno, J.L. Rouleau Bradykinin and des-Arg(9)-bradykinin metabolic pathways and kinetics of activation of human plasma Am J Physiol Heart Circ Physiol 281 2001 H275 H283
32. D.L. Kreutzer, J.R. McCormick, A. Despins, M. Moore, J.H. Rousou, W. Dobbs Characterization of the anaphylatoxin inactivator and chemotactic factor inactivator activities during cardiopulmonary bypass J Exp Pathol 1 1984 183 187
33. C. Mazenot, L. Loufrani, D. Henrion, C. Ribuot, W. Muller-Esterl, D. Godin-Ribuot Endothelial kinin B1-receptors are induced by myocardial ischaemia-reperfusion in the rabbit J Physiol (Lond) 530 2001 69 78
34. P.G. McLean, M. Perretti, A. Ahluwalia Kinin B1 receptors and the cardiovascular system regulation of expression and function Cardiovasc Res 48 2000 194 210
35. M.E. Marin-Castano, J.P. Schanstra, E. Neau, F. Praddaude, C. Pecher, J.-L. Ader Induction of functional bradykinin B1-receptors in normotensive rats and mice under chronic angiotensin-converting enzyme inhibitor treatment Circulation 105 2002 627 632
36. N.L. Cruden, G.H. Tse, K.A. Fox, C.A. Ludlam, I. Megson, D.E. Newby B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure Arterioscler Thromb Vasc Biol 25 2005 772 777
37. M. Cugno, J. Nussberger, P. Biglioli, F. Alamanni, R. Coppola, A. Agostoni Increase of bradykinin in plasma of patients undergoing cardiopulmonary bypass - the importance of lung exclusion Chest 120 2001 1776 1782
38. H. Okada, Y. Watanabe, T. Kikuta, T. Kobayashi, Y. Kanno, T. Sugaya Bradykinin decreases plasminogen activator inhibitor-1 expression and facilitates matrix degradation in the renal tubulointerstitium under angiotensin-converting enzyme blockade J Am Soc Nephrol 15 2004 2404 2413
39. R. Korbut, E. Marcinkiewicz, K. Cieslik, R.J. Gryglewski The effect of nitric oxide donors on the release of plasminogen activator inhibitor (PAI) from rabbit platelets in vitro J Physiol Pharmacol 46 1995 37 44
40. W. Linz, G. Wiemer, B.A. Scholkens Role of kinins in the pathophysiology of myocardial ischemia. In vitro and in vivo studies Diabetes 45 Suppl 1 1996 S51 S58
41. H. Ito, I. Hayashi, T. Izumi, M. Majima Bradykinin inhibits development of myocardial infarction through B2 receptor signalling by increment of regional blood flow around the ischaemic lesions in rats Br J Pharmacol 138 2003 225 233
42. R.J. Gryglewski, J. Swies, W. Uracz, S. Chlopicki, E. Marcinkiewicz Mechanisms of angiotensin-converting enzyme inhibitor induced thrombolysis in Wistar rats Thromb Res 110 2003 323 329
43. S.A. Omoro, D.S. Majid, S.S. El-Dahr, L.G. Navar Kinin influences on renal regional blood flow responses to angiotensin-converting enzyme inhibition in dogs Am J Physiol 276 1999 F271 F277