Fetal placental thrombosis and neonatal implications

American Journal of Perinatology

Volumn 27, Issue 3, 2010, Pages 251-256

  Wintermark, Pia ^a,b   Boyd, Theonia ^c   Parast, Mana M ^b   Van Marter, Linda J ^a   Warfield, Simon K ^b   Robertson, Richard L ^b   Ringer, Steven A ^d  

^a Division of Newborn Medicine   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c Department of Pathology ^*  (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Brain infarct; Fetal thrombotic vasculopathy; Newborn; Placenta

Indexed keywords

FRESH FROZEN PLASMA; IBUPROFEN; LUNG SURFACTANT;

ADVERSE OUTCOME; APGAR SCORE; APNEA; BRAIN HEMORRHAGE; CESAREAN SECTION; CLINICAL FEATURE; DISEASE PREDISPOSITION; DISEASE SEVERITY; DISSEMINATED INTRAVASCULAR CLOTTING; ECHOGRAPHY; FETUS CIRCULATION; FETUS HYPOXIA; FETUS MOVEMENT; GENE MUTATION; HUMAN; HYPOGLYCEMIA; INTUBATION; NEWBORN INTENSIVE CARE; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCLUSIVE CEREBROVASCULAR DISEASE; OXYGEN THERAPY; PATENT DUCTUS ARTERIOSUS; PLACENTA DISORDER; PLACENTAL THROMBOSIS; PLASMA TRANSFUSION; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; RESPIRATORY DISTRESS SYNDROME; REVIEW; SMALL FOR DATE INFANT; THROMBOCYTOPENIA; THROMBOSIS;

ADULT; FEMALE; FETAL DISEASES; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; MALE; PLACENTA; PLACENTA DISEASES; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY COMPLICATIONS, HEMATOLOGIC; THROMBOSIS;

EID: 77449158824     PISSN: 07351631     EISSN: 10988785     Source Type: Journal    
DOI: 10.1055/s-0029-1239486     Document Type: Review

References (16)

1. Gruenwald P. Fetal deprivation and placental pathology: concepts and relationships. Perspect Pediatr Pathol 1975 2 101-149
2. Ariel I, Anteby E, Hamani Y, Redline R W. Placental pathology in fetal thrombophilia. Hum Pathol 2004 35 729-733
3. Redline R W. Severe fetal placental vascular lesions in term infants with neurologic impairment. Am J Obstet Gynecol 2005 192 452-457
4. Kraus F T., Acheen V I. Fetal thrombotic vasculopathy in the placenta: cerebral thrombi and infarcts, coagulopathies, and cerebral palsy. Hum Pathol 1999 30 759-769
5. McDonald D G., Kelehan P, McMenamin J B. et al. Placental fetal thrombotic vasculopathy is associated with neonatal encephalopathy. Hum Pathol 2004 35 875-880
6. Redline R W. Placental pathology: a systematic approach with clinical correlations. Placenta 2008 29 (suppl A) S86-S91
7. Redline R W. Clinical and pathological umbilical cord abnormalities in fetal thrombotic vasculopathy. Hum Pathol 2004 35 1494-1498
8. Dikmen M, Ozbabalik D, Gunes H V. et al. Acute stroke in relation to homocysteine and methylenetetrahydrofolate reductase gene polymorphisms. Acta Neurol Scand 2006 113 307-314
9. Trabetti E. Homocysteine, MTHFR gene polymorphisms, and cardio-cerebrovascular risk. J Appl Genet 2008 49 267-282
10. Redline R W., Pappin A. Fetal thrombotic vasculopathy: the clinical significance of extensive avascular villi. Hum Pathol 1995 26 80-85
11. Redline R W. Elevated circulating fetal nucleated red blood cells and placental pathology in term infants who develop cerebral palsy. Hum Pathol 2008 39 1378-1384
12. Dahms B B., Boyd T, Redline R W. Severe perinatal liver disease associated with fetal thrombotic vasculopathy. Pediatr Dev Pathol 2002 5 80-85
13. Redline R W., Shah D, Sakar H, Schluchter M, Salvator A. Placental lesions associated with abnormal growth in twins. Pediatr Dev Pathol 2001 4 473-481
14. Leistra-Leistra M J., Timmer A, van Spronsen F J., Geven W B., van der Meer J, Erwich J J. Fetal thrombotic vasculopathy in the placenta: a thrombophilic connection between pregnancy complications and neonatal thrombosis? Placenta 2004 25 (suppl A) S102-S105
15. Khong T Y., Hague W M. Biparental contribution to fetal thrombophilia in discordant twin intrauterine growth restriction. Am J Obstet Gynecol 2001 185 244-245
16. Vern T Z., Alles A J., Kowal-Vern A, Longtine J, Roberts D J. Frequency of factor V(Leiden) and prothrombin G20210A in placentas and their relationship with placental lesions. Hum Pathol 2000 31 1036-1043