Experimental testing of a mathematical model relevant to the extrinsic pathway of apoptosis

Cell Stress and Chaperones

Volumn 15, Issue 1, 2010, Pages 13-23

  Pace, Vincenza ^a   Bellizzi, Dina ^a   Giordano, Francesca ^a   Panno, Maria Luisa ^a   De Benedictis, Giovanna ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

Author keywords

Apoptosis; BAR regulation; Caspase 3 activation; Caspase 8 activation; Mathematical model

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; CASPASE 3; CASPASE 8; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; BIOLOGICAL MODEL; GENETICS; HUMAN; METABOLISM; TUMOR CELL LINE;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASE 3; CASPASE 8; CELL LINE, TUMOR; HUMANS; MODELS, BIOLOGICAL; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 77449139952     PISSN: 13558145     EISSN: 14661268     Source Type: Journal    
DOI: 10.1007/s12192-009-0118-9     Document Type: Article

References (27)

1. Auffray C, Imbeaud S, Roux-Rouquié M, Hood L (2003) From functional genomics to system biology: concepts and practices. CR Biol 326:879-892. doi:10.1016/j.crvi.2003.09.033 (Pubitemid 38016443)
2. Bagci EZ, Vodovotz Y, Billiar TR, Ermentrout GB, Bahar I (2006) Bistability in apoptosis: roles of Bax, bcl-2 and mitochondrial permeability transition pores. Biophys J 90:1546-1559. doi:10.1529/biophysj.105.068122
3. Bentele M, Lavrik I, Ulrich M, Stosser S, Heermann DH, Kalthoff H, Krammer PH, Eils R (2004) Mathematical modelling reveals threshold mechanism in CD95-induced apoptosis. J Cell Biol 166:839-851. doi:10.1083/jcb.200404158 (Pubitemid 39249835)
4. Bialik S, Cryns VL, Drincic A, Miyata S, Wollowick AL, Srinivasan A, Kitsis RN (1999) The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes. Circ Res 85:403-414 (Pubitemid 29409617)
5. Bortner CD, Oldenburg NB, Cidlowski JA (1995) The role of DNA fragmentation in apoptosis. Trends Cell Biol 5:21-26. doi:10.1016/S0962-8924 (00) 88932-1
6. Carotenuto L, Pace V, Bellizzi D, De Benedictis G (2007a) Equilibrium, stability and dynamical response in a model of the extrinsic apoptosis pathway. J Biol Syst 15:261-285. doi:10.1142/S0218339007002192 (Pubitemid 47479184)
7. Carotenuto L, Pace V, Bellizzi D, De Benedictis G (2007b) Dynamical Analysis of the Programmed Cell Death Pathway. In: Tzafestas S (ed) Proceedings of the European Control Conference 2007 (ECC'07), Kos, 2-5 July 2007, pp 3747-3754. http://biologia. unical.it/genetica/Carotenuto-et-al.pdf
8. Degterev A, Yuan J (2008) Expansion and evolution of cell death programmes. Nat Rev Mol Cell Biol 9:378-390. doi:10.1038/nrm2393 (Pubitemid 351574200)
9. Dubrez-Daloz L, Dupoux A, Cartier J (2008) IAPs: more than just inhibitors of apoptosis proteins. Cell Cycle 7:1036-1046
10. Eissing T, Conzelmann H, Gilles ED, Allgower F, Bullinger E, Scheurich P (2004) Bistability analyses of a caspase activation model for receptor-induced apoptosis. J Biol Chem 279:36892-36897. doi:10.1074/jbc. M404893200 (Pubitemid 39129038)
11. Eissing T, Allgower F, Bullinger E (2005) Robustness properties of apoptosis models with respect to parameter variations and intrinsic noise. Syst Biol 12:221-228 (Pubitemid 43125140)
12. Fussenegger M, Bailey JE, Varner JA (2000) Mathematical model of caspase function in apoptosis. Nat Biotechnol 18:768-774. doi:10.1038/81208 (Pubitemid 30460695)
13. Hague A, Paraskeva C (2004) Apoptosis and disease: a matter of cell fate. Cell Death Differ 11:1366-1372. doi:10.1038/sj.cdd. 4401497 (Pubitemid 39591782)
14. King MP, Attardi G (1996) Isolation of human cell lines lacking mitochondrial DNA. Methods Enzymol 264:304-313. doi:10.1016/S0076-6879 (96) 64029-4 (Pubitemid 26089319)
15. Krysko DV, Vanden Berghe T, D'Herde K, Vandenabeele P (2008) Apoptosis and necrosis: detection, discrimination and phagocytosis. Methods 44:205-221. doi:10.1016/j.ymeth.2007.12.001 (Pubitemid 351296447)
16. Legewie S, Bluthgen N, Herzel H (2006) Mathematical modelling identifies inhibitors of apoptosis as mediators of positive feedback and bistability. PLos Comput Biol 2:1061-1073. doi:10.1371/journal.pcbi.0020120 (Pubitemid 44495720)
17. Marsden VS, Strasser A (2003) Control of apoptosis in the immune system: Bcl-2, BH3-Only proteins and more. Annu Rev Immunol 21:71-105. doi:10.1146/annurev. immunol.21.120601.141029 (Pubitemid 37174527)
18. Opferman JY, Korsmeyer SJ (2003) Apoptosis in the development and maintenance of the immune system. Nat Immunol 4:410-415. doi:10.1038/ni0503-410 (Pubitemid 36592430)
19. Pillich RT, Scarsella G, Risuleo G (2005) Reduction of apoptosis through the mitochondrial pathway by the administration of acetyl-l-carnitine to mouse fibroblasts in culture. Exp Cell Res 306:1-8. doi:10.1016/j.yexcr.2005.01.019 (Pubitemid 40692766)
20. O'Connor CL, Anguissola S, Huber HJ, Dussmann H, Prehn JH, Rehm M (2008) Intracellular signaling dynamics during apoptosis execution in the presence or absence of X-linked-inhibitor-ofapoptosisprotein. Biochim Biophys Acta 1783:1903-1913. doi:10.1016/j.bbamcr.2008.05.025
21. Rehm M, Huber HJ, Dussmann H, Prehn J H M (2006) Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein. EMBO J 25:4338
22. Salvesen GS, Riedl SJ (2008) Caspase mechanisms. Adv Exp Med Biol 615:13-23
23. Stucki JW, Simon HU (2005) Mathematical modelling of the regulation of caspase-3 activation and degradation. J Theor Biol 23:123-131. doi:10.1016/j.jtbi.2004.11.011 (Pubitemid 40249854)
24. Takeda S, Iwai A, Nakashima M et al (2007) LKB1 is crucial for TRAIL-mediated apoptosis induction in osteosarcoma. Anticancer Res 27:761-768 (Pubitemid 46586979)
25. Van England M, Nieland L J W, Ramaekers F C S, Schutte B, Reutelingsperger CP (1998) Annexin V-Affinity Assay: A review on an apoptosis detection system based on phosphatydilserine exposure. Cytometry 31:1. doi:10.1002/(SICI) 1097-0320 (19980101) 31:1<1::AID-CYTO1>3.0. CO;2-R
26. Wolkenhauer O (2007) Defining systems biology: an engineering perspective. IET Syst Biol 1:204-206. doi:10.1049/iet-syb: 20079017 (Pubitemid 47097370)
27. Zhang H, Xu Q, Krajewski S, Krajewska M, Xie Z, Fuess S, Kitada S, Pawlowski K, Godzik A, Reed JC (2000) BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins. Proc Natl Acad Sci U S A 97:2597-2602. doi:10.1073/pnas. 97.6.2597 (Pubitemid 30159216)