Commentary: How important is the anti-gal antibody response following the implantation of a porcine bioprosthesis?

Journal of Heart Valve Disease

Volumn 18, Issue 6, 2009, Pages 671-672

  Cooper, David K C ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GALACTOSE; GALACTOSYLTRANSFERASE;

ANIMAL; ARTICLE; BIOPROSTHESIS; FEMALE; GENETICS; GRAFT REJECTION; HEART VALVE PROSTHESIS; IMMUNOLOGY; SWINE; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BIOPROSTHESIS; FEMALE; GALACTOSE; GALACTOSYLTRANSFERASES; HEART VALVE PROSTHESIS; HOST VS GRAFT REACTION; SWINE;

EID: 77449139028     PISSN: 09668519     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Note

References (5)

1. Galili U, Shohet SB, Kobrin E, Stults CL, Macher BA. Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells. J Biol Chem 1988;263:17755-17762
2. Good AH, Cooper DKC, Malcolm AJ, et al. Identification of carbohydrate structures that bind human antiporcine antibodies: Implications for discordant xenografting in man. Transplant Proc 1992;24:559-562
3. Phelps CJ, Koike C, Vaught TD, et al. Production of α1, 3-galactosyltransferase-deficient pigs. Science 2003;299:411-414
4. Cooper DKC, Dorling A, Pierson RN, III, et al. α1, 3-galactosyltransferase gene-knockout pigs for xenotransplantation: Where do we go from here? Transplantation 2007;84:1-7 (Pubitemid 47094631)
5. Konakci KZ, Bohle B, Blumer R, et al. Alpha-Gal on bioprostheses: Xenograft immune response in cardiac surgery. Eur J Clin Invest 2005;35:17-23 (Pubitemid 40187950)