Impact of disease-causing SUR1 mutations on the KATP channel subunit interface probed with a rhodamine protection assay

Journal of Biological Chemistry

Volumn 285, Issue 5, 2010, Pages 3084-3091

  Hosy, Eric ^a,b   Dupuis, Julien P ^a,c   Vivaudou, Michel ^a  

^a INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^b University of Bordeaux   (France)

^c Université Paul Sabatier   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED CONFORMATION; CHANNEL DENSITY; CHANNEL FUNCTIONS; GATING MODE; PLASMA MEMBRANES; PROTECTION ASSAY; RELATIVE POSITIONS; RHODAMINE 123; SECOND INTRACELLULAR LOOPS; STRUCTURAL ELEMENTS; SUBUNIT INTERFACES; SURFACE EXPRESSION; TRANSMEMBRANE DOMAIN;

ACTIVATION ANALYSIS; CELL MEMBRANES; POTASSIUM;

ZINC;

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; RHO FACTOR; RHODAMINE; SULFONYLUREA RECEPTOR 1; ABC TRANSPORTER; DRUG RECEPTOR; INWARDLY RECTIFYING POTASSIUM CHANNEL; ISOPROTEIN; SULFONYLUREA RECEPTOR; ZINC;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; GENE EXPRESSION; GENETIC STABILITY; HYPERINSULINISM; JUVENILE DIABETES MELLITUS; MOLECULAR PROBE; MUTATIONAL ANALYSIS; NEWBORN DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRANSPORT; STRUCTURE ANALYSIS; ANIMAL; CHEMISTRY; FEMALE; GENETICS; HAMSTER; METABOLISM; MOUSE; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; RAT; XENOPUS;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CRICETINAE; FEMALE; MICE; MUTATION; PHENOTYPE; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ISOFORMS; RATS; RECEPTORS, DRUG; RHODAMINES; XENOPUS; ZINC;

EID: 77449116387     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.043307     Document Type: Article

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